DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bi and Tbr1

DIOPT Version :9

Sequence 1:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_033348.2	Gene:	Tbr1 / 21375	MGIID:	107404	Length:	681	Species:	Mus musculus

Alignment Length:	694	Identity:	207/694 - (29%)
Similarity:	279/694 - (40%)	Gaps:	174/694 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 NLVAVSPTGGGAQLSPQSNHSSSNTTTTSNTNNSSSNNNNNNSTHNNNNNHTNNNNNNNNNTSQK 144
            |:.:..|..||::|   ..|.....:||.|...||.........  .|.:.|:|..::.::....
Mouse    19 NVSSSYPHSGGSEL---VLHDHPIISTTDNLERSSPLKKITRGM--TNQSDTDNFPDSKDSPGDV 78

  Fly   145 QGHHLSTTEEPPSPAGTPPPTIVGLPPIPPPNNNSSS-----SSSNNSASAAAHPS-HHPTAAHH 203
            |...||             |.:.|:..:....:.|::     |.|:...|||..|| ..|..:.|
Mouse    79 QRSKLS-------------PVLDGVSELRHSFDGSAADRYLLSQSSQPQSAATAPSAMFPYPSQH 130

  Fly   204 SPSTGAAAPPAGATGLPPPTPPHHLQQQQQQQQHPAPPPPPYFPAAALAALA--GSPAGPHPGLY 266
            .|     |.||.:.|.|.....||                |.....|..:|.  .||.|     |
Mouse   131 GP-----AHPAFSIGSPSRYMAHH----------------PVITNGAYNSLLSNSSPQG-----Y 169

  Fly   267 PGGGLRFPPHHPGAHPHAHHLGSAYTTAEDVVLASAVAHQLHPAMRPLRALQPEDDGVVDDPKVT 331
            |..|          :|:....|.:|..|.....:|.     .|.:.|.:|            :|.
Mouse   170 PTAG----------YPYPQQYGHSYQGAPFYQFSST-----QPGLVPGKA------------QVY 207

  Fly   332 LEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILLLDIVAADDYRYKFHNSRWM 396
            |..:.||.|||:..|||:|||.||:|||.:.|.:||||..|.|.:.:|::.||...::|...:|:
Mouse   208 LCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWV 272

  Fly   397 VAGKADPEMP-KRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDKHGFVSTTILNSMHKYQPRF 460
            ..||||..:. .|:|:|||||.||..||::.:||.|||||||....:......:|.|:||||||.
Mouse   273 PCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQPRL 337

  Fly   461 HLVRAN----DILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKIDNNPFAKGFRDTGAGKREK 521
            |:|..|    :....| ...:|:.|.||:|||||||||..|||||||:|||||||||
Mouse   338 HVVEVNEDGTEDTSQP-GRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRD-------- 393

  Fly   522 KQALMSN-----RGSDSDKLNPTHVSSSR--------------------------APLHLGHAGR 555
                  |     .|.|.|:|.|:...|.|                          |..|.|....
Mouse   394 ------NYDTIYTGCDMDRLTPSPNDSPRSQIVPGARYAMAGSFLQDQFVSNYAKARFHPGAGAG 452

  Fly   556 P--------PHLHPHAALLDNQQDDDDKLLDVVGPPQSP----LLPLSHSLQQMHAHQHSAALAA 608
            |        ||.:   .||..||.:|.      |.| ||    :.|.::.| ...|..:..|
Mouse   453 PGPGTDRSVPHTN---GLLSPQQAEDP------GAP-SPQRWFVTPANNRL-DFAASAYDTA--- 503

  Fly   609 WFNHLAGAGAGASEHAAAA--AANASAEDALRRRLQADADVERDGSDSS---CSESVGGSTGGAF 668
              ...||..|....:|||.  |....|.....|.|...||....|:.|.   |     |:..|:.
Mouse   504 --TDFAGNAATLLSYAAAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYC-----GAKSGSV 561

  Fly   669 RPTSTGSPKEAVGAAAAAAAAGLNPGGGSYPSPNISVGPPIHPS 712
            .|....|      |||||..||.||..|.......:...|:.|:
Mouse   562 LPCWPNS------AAAAARMAGANPYLGEEAEGLAAERSPLAPA 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	12/57 (21%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	93/187 (50%)
Tbr1	NP_033348.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..83		8/41 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..127		8/18 (44%)
		TBOX	203..396	CDD:238106	97/219 (44%)
		T-box_assoc	418..679	CDD:374412	50/209 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..483		13/45 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..655		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810