DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bi and tbx6

DIOPT Version :9

Sequence 1:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_705952.2	Gene:	tbx6 / 192294	ZFINID:	ZDB-GENE-020416-5	Length:	874	Species:	Danio rerio

Alignment Length:	814	Identity:	215/814 - (26%)
Similarity:	328/814 - (40%)	Gaps:	217/814 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   277 HPGAHPHAHHLGSAYTTAEDVVL----ASAVAHQLHPAMRPLRALQPEDDGVVDDP-------KV 330
            :||.......|...|....||.|    ....|..|.||:     |:|..:  .|.|       ::
Zfish     7 YPGLALGPQRLSDCYYRDRDVPLYPSTCEMAARALPPAL-----LKPHAN--TDSPATPQDSVRM 64

  Fly   331 TLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILLLDIVAADDYRYKFHNSRW 395
            .||...||::|..:||||::||.||:||||::.::|||:...:||||||||..|..||:|.::.|
Zfish    65 ELENAGLWKQFSTVGTEMIVTKKGRRMFPQLRVKLSGLNPSLRYILLLDIVPVDSSRYRFQDNSW 129

  Fly   396 MVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDKHGFVSTTILNSMHKYQPRF 460
            .|.|.|:..:|.|::||||||.|||.|..:.:|||:.|||||..|..|::   ||:|:|:||||.
Zfish   130 QVVGGAEARLPDRVFIHPDSPATGEHWQNRTISFHRAKLTNNTLDAQGYI---ILHSLHRYQPRV 191

  Fly   461 HLVRANDILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKIDNNPFAKGFRDTGAGKREKKQAL 525
            |::.|.|:| :...|..::.|.||:||.||||||.|||:|||::||||||||:.|...:::::|.
Zfish   192 HVIEARDVL-MWGRTQHSFTFPETQFITVTAYQNNKITELKINSNPFAKGFRENGMNCKKQREAR 255

  Fly   526 MSNR---------------GSDSDKLNPTHVSSSRAPLHLGHAGRP---------PHLHPH---- 562
            :..:               ..||.:|.|..|....:.|.:.:...|         ...||.
Zfish   256 LKRKITSSQEECLDIESCDPCDSTELLPQSVDLPSSALTIMNTALPITDSGFHTEVSSHPDQTDS 320

  Fly   563 ---------------AALLDNQQ-------------DDDDKLLDVVGPPQS---PLL------PL 590
                           .:.:::||             |:..:::|:.|...|   |.|      |.
Zfish   321 DQTLVLEQAFLTSEMPSSMESQQQTTSETNVNNALMDETGQMMDLSGYTSSFPTPQLSSHTSVPQ 385

  Fly   591 SHSLQQMHAHQHSAALAAWFNHLAGAGAGASEHAAAAAAN-ASAE-------DALRRRLQADADV 647
            |.|:..:.:...|:.|     .|..|.:.:|.|:..|.:: .|||       .|:.....:.:|.
Zfish   386 SSSMYSVVSSTQSSDL-----ELPQASSISSPHSMPAYSSIPSAEYPGVNSSTAMPASTTSLSDS 445

  Fly   648 ERDGSDSSCSESVGGSTGGAFRPTS-----------TGSPKEAVGA------------------- 682
            ....|.|:.|..:..|:..:..||.           |..|.:::.|
Zfish   446 YPSISHSTSSHLLQSSSYHSLLPTDQSQDNLSPHTPTNPPFQSIPACQGTRLTIDSGQNQVDDGG 510

  Fly   683 ---AAAAAAAGLNPGGGSYPSPNISVG---PPIHPS-------------------------PHLL 716
               |.|...|..||...::|.|.:...   .|..||                         |:..
Zfish   511 LSSANATTPAVPNPTQTAFPFPPVQPNNDPDPTSPSCQSLPQSALPYQQVSQCNQIPTPSDPNTT 575

  Fly   717 PYLYPHGLYPPPH------LGLLHNPAAAAAMSPAGLNPGLLFNAQLALAAQHPALFGHAYAA-- 773
            |..:|   :||..      :.:..||...|...|.       ...||.|:...|:.|..:.::
Zfish   576 PTAFP---FPPSEQSTPNSIMVSSNPNTTAFPFPP-------VQQQLNLSTSGPSSFPVSQSSGL 630

  Fly   774 -AGHTPVSPLQGLKS-------HRFSPYSLPGSLGSAFDAVTPGSNANRSGDPPGGGGGGLGGGV 830
             |...||.|..|..|       |:....|:|.:|..:.....|.|.
Zfish   631 NAIPNPVHPTTGSFSFPSTSAIHQGPMQSVPNTLHPSTAYTFPSSL------------------- 676

  Fly   831 VENGPRSLSSSPRPRPASHSPPTRPISMSP-----TTPPSLMKQPRGGGAGAGVAQSQHSPSELK 890
                |:.....|.|.|.|:..|| ||...|     .|.||....|......:...||.|:||...
Zfish   677 ----PKHTGPLPNPAPTSYPFPT-PIPPGPHPLQSLTLPSSCSIPNTSQIQSTFPQSYHNPSFSH 736

  Fly   891 SMEKMVNGLEV-QHNGSAAAAAAALQLAEEAAQH 923
            ...:|.|..:: ..:......::|.||..:::.|
Zfish   737 IPPQMANHSQITSQSFPPLQTSSAPQLLSQSSTH 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	11/44 (25%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	95/182 (52%)
tbx6	NP_705952.2	TBOX	62..247	CDD:238106	97/188 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..396		8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..453		3/24 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	466..551		15/84 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..626		14/72 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..695		8/53 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	720..776		11/51 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810