DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bi and Eomes

DIOPT Version :9

Sequence 1:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_034266.2	Gene:	Eomes / 13813	MGIID:	1201683	Length:	707	Species:	Mus musculus

Alignment Length:	690	Identity:	198/690 - (28%)
Similarity:	269/690 - (38%)	Gaps:	216/690 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 PSPAGTPPPTIVGLPPIPPPNNNSSSSSSNNSASAAAHP------SHHPTAAHHSPSTGAAAPPA 214
            |..||:..|...|........:::.:..:..|.||.|.|      ...|.|....||...||..|
Mouse    70 PCQAGSAEPAGAGAGAPAAMLSDADAGDTFGSTSAVAKPGPPDGRKGSPCAEEELPSAATAAATA 134

  Fly   215 GAT---------GLPPPTPP-HHLQQQQQQQQHPAPP----------------------PPPYFP 247
            ..:         .||.|.|. ..|.......|:||..                      ||..||
Mouse   135 RYSMDSLSSERYYLPSPGPQGSELAAPCSLFQYPAAAGAAHGPVYPASNGARYPYGSMLPPGGFP 199

  Fly   248 AAAL---------AALAGSPAGPHPGLYPGGGLRFPPHHPGAHPHAHHLGS------AYTTAEDV 297
            ||..         ||.:||.||...|   |.|      .|||:|:..  ||      |.|:|...
Mouse   200 AAVCPPARAQFGPAAGSGSGAGSSGG---GAG------GPGAYPYGQ--GSPLYGPYAGTSAAGS 253

  Fly   298 --------VLASAVAHQLHPAMRPLRALQPEDDGVVDDPKVTLEGKDLWEKFHKLGTEMVITKSG 354
                    |..|.....::...||                       ||.|||:..|||:|||.|
Mouse   254 CGGLGGLGVPGSGFRAHVYLCNRP-----------------------LWLKFHRHQTEMIITKQG 295

  Fly   355 RQMFPQMKFRVSGLDAKAKYILLLDIVAADDYRYKFHNSRWMVAGKADPEMP-KRMYIHPDSPTT 418
            |:|||.:.|.::||:..|.|.:.:::|.||...::|...:|:..||||..|. .:||:||:||.|
Mouse   296 RRMFPFLSFNINGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNKMYVHPESPNT 360

  Fly   419 GEQWMQKVVSFHKLKLTNNISDKHGFVSTTILNSMHKYQPRFHLVRAN----DILKLPYSTFRTY 479
            |..||::.:||.|||||||....:......:|.|:||||||.|:|...    :.|..|..| :|:
Mouse   361 GSHWMRQEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGVEDLNEPSKT-QTF 424

  Fly   480 VFKETEFIAVTAYQNEKITQLKIDNNPFAKGFRDTGAGKREKKQALMSNRGSDSDKLNPTHVSSS 544
            .|.||:|||||||||..|||||||:|||||||||       ...::.:  .|::|:|.|:...|.
Mouse   425 TFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRD-------NYDSMYT--ASENDRLTPSPTDSP 480

  Fly   545 RAPLHLGHAGR--------PPHLH--PHA-------------ALLDNQQDDDDKLLDVVGPPQ-- 584
            |:. .:...||        .|.::  |.|             .||..||.:     :|..|||
Mouse   481 RSH-QIVPGGRYGVQNFFPEPFVNTLPQARYYNGERTVPQTNGLLSPQQSE-----EVANPPQRW 539

  Fly   585 ------------------------SPLLPL---SHSLQQMHAHQH-----SAALAAWFNHLAGAG 617
                                    |.|||.   |..||..||..:     ..|:|.|      .|
Mouse   540 LVTPVQQPVTNKLDIGSYESEYTSSTLLPYGIKSLPLQTSHALGYYPDPTFPAMAGW------GG 598

  Fly   618 AGASEHAAAAAANASA--------EDALRRRLQADADVERDGSDS-----SCSESVGGSTGGAFR 669
            .||.:...||....::        ||.|     |...|:.:.|.|     ...:|:..|..|.:.
Mouse   599 RGAYQRKMAAGLPWTSRMSPPVFPEDQL-----AKEKVKEEISSSWIETPPSIKSLDSSDSGVYN 658

  Fly   670 PTSTGSPKEAVGAAAAAAAAGLNPGGGSYPSPNISVGPPI 709
                          :|.....|:|.     :|:....|||
Mouse   659 --------------SACKRKRLSPS-----TPSNGNSPPI 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	17/71 (24%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	90/187 (48%)
Eomes	NP_034266.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..125		12/54 (22%)
		TBOX	269..462	CDD:238106	94/223 (42%)
		T-box_assoc	484..705	CDD:292794	47/231 (20%)
		Required for transcription activation. /evidence=ECO:0000250	592..707		25/118 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	642..689		10/57 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810