DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bi and eomes

DIOPT Version :9

Sequence 1:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_001122124.1	Gene:	eomes / 100038065	XenbaseID:	XB-GENE-479769	Length:	667	Species:	Xenopus tropicalis

Alignment Length:	615	Identity:	189/615 - (30%)
Similarity:	257/615 - (41%)	Gaps:	126/615 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 NTSQKQGHHLSTTEEPPSPAGTPPPTIVGLPPIPPPNNNSSSSSSNNSASAAAHPSHHPTAAHHS 204
            :||...|..||.|.|..|.|.|           .|.|....|.|:....|.|.
Frog    64 STSTASGTMLSETGEAFSVAKT-----------LPDNGRKGSPSAEEELSTAV------------ 105

  Fly   205 PSTGAAAPPAGATGLPPPTPPHHLQQQQQQQQHPAP---PPPPYFPAAALAALAGSPAGPHPGLY 266
            ||   :||....:.|...:..::||.|.||.|..|.   .|...||.|         ...|..:|
Frog   106 PS---SAPRYLDSSLQAASERYYLQPQGQQPQQAATELGSPCSIFPYA---------PPQHSAVY 158

  Fly   267 P-GGGLRFPPH---------HPGAHPHAHHLGSAYTTAEDVVLASAVAHQLHPAM---RPLRALQ 318
            | ||..|:||:         .|...|......|.|..::    |....:..:|..   ..|.||.
Frog   159 PAGGAARYPPYGSMLPPAGFSPPVCPSRPQYSSGYQYSQ----APGTMYSPYPPAGTGSGLSALG 219

  Fly   319 PEDDGVVDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILLLDIVAA 383
            ....|.....:|.|..:.||.|||:..|||:|||.||:|||.:.|.::||:..|.|.:.:::|.|
Frog   220 LPGGGAGVRAQVFLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNITGLNPTAHYNVFVEVVLA 284

  Fly   384 DDYRYKFHNSRWMVAGKADPEMP-KRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDKHGFVST 447
            |...::|...:|:..||||..|. .::|:||:||.||..||::.:||.|||||||....:.....
Frog   285 DPNHWRFQGGKWVTCGKADNNMQGNKVYVHPESPNTGAHWMRQEISFGKLKLTNNKGANNNSTQM 349

  Fly   448 TILNSMHKYQPRFHLVRA--------NDILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKIDN 504
            .:|.|:||||||.|:|..        ||..|     .:|:.|.||:|||||||||..|||||||:
Frog   350 IVLQSLHKYQPRLHIVEVSEDGVEDLNDSAK-----SQTFTFPETQFIAVTAYQNTDITQLKIDH 409

  Fly   505 NPFAKGFRDTGAGKREKKQALMSNRGSDSDKLNPTHVSSSRAPLHLGHAGRPPHLHPHAALLDNQ 569
            |||||||||       ...::.:  .|:||:|.|:...|.|:  |....|....:.|..
Frog   410 NPFAKGFRD-------NYDSMYT--ASESDRLTPSPADSPRS--HQIVPGTRYSVQPFF------ 457

  Fly   570 QDDDDKLLDVVGPPQ----SPLLPLSHSL--QQMHAHQHSAALAAWFNHLAGAGAGASEHAAAAA 628
               .|:.::.:.|.:    ...:|.::.|  .|.:....:|....||          ......||
Frog   458 ---QDQFVNNLPPARYYSGERTVPQANGLLSPQTNDEVANAPPQRWF----------VTPVQQAA 509

  Fly   629 ANASAEDALRRRLQADADVERDGSDSSCSESVGGSTGGAFRPTSTGSPKEAVGAAAAAAAAGLNP 693
            ||         :|...| .|.|.|..|..     :.|....|..|..|......||.|:.||...
Frog   510 AN---------KLDMGA-YETDYSSGSLL-----TYGIKSLPIQTSHPMAYYPDAAFASMAGWGS 559

  Fly   694 GGGSYPS------PNISVGPPIHPSPHLLP 717
            .|.:|..      |..|...|...|..|||
Frog   560 RGSTYQRKMTTTLPWSSRSSPSGFSEDLLP 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	16/70 (23%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	91/191 (48%)
eomes	NP_001122124.1	T-box	231..418	CDD:366363	91/191 (48%)
eomes	NP_001122124.1	T-box_assoc	444..665	CDD:374412	38/180 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000