DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3626 and PDPR

DIOPT Version :9

Sequence 1:	NP_572162.2	Gene:	CG3626 / 31377	FlyBaseID:	FBgn0029706	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_001309046.1	Gene:	PDPR / 55066	HGNCID:	30264	Length:	879	Species:	Homo sapiens

Alignment Length:	912	Identity:	386/912 - (42%)
Similarity:	557/912 - (61%)	Gaps:	47/912 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VSVVPRRRWCSPGLSN--AVRLSSSQMDPADERVLRKRKFQPQQAADLSEELAGQLPVKSRVVIC 74
            :|:|.|:| .|||..|  :.|.|:|                      .:|..:..||.:::||||
Human     7 LSIVGRQR-ASPGWQNWSSARNSTS----------------------AAEARSMALPTQAQVVIC 48

  Fly    75 GGGITGASVAYHLGLRGWGGETLLVEQDRVGGELPWTACGLAGRFEPSYTELKLAEYSIDLIKRL 139
            ||||||.||||||...|| .:.:|:||.|:.........|:.........|.|:|:||..|..:|
Human    49 GGGITGTSVAYHLSKMGW-KDIVLLEQGRLAAGSTRFCAGILSTARHLTIEQKMADYSNKLYYQL 112

  Fly   140 -AENGLPTGWRPVGSLNLARSWDRMTAFNRMKSQALAWGMHCEILSPEQCAQHCELLSLDGIEGG 203
             .|.|:.||:...||:.||::.||:.:..|:.:.....|:..||:||::.|:...||::..:.|.
Human   113 EQETGIQTGYTRTGSIFLAQTQDRLISLKRINAGLNVIGIPSEIISPKKVAELHHLLNVHDLVGA 177

  Fly   204 LWIPEDGVCDPQLVCQAYMIEAQRLGVRIVEHCAIKKIHSEHGKVRSVETTAGDVECEYFVNCTG 268
            :.:|||.|.....|..|....|.:.||:|.:..::..:..:.|:|..|||..|.:||:|||||.|
Human   178 MHVPEDAVVSSADVALALASAASQNGVQIYDRTSVLHVMVKKGQVTGVETDKGQIECQYFVNCAG 242

  Fly   269 FWAREVGTLSKPVVKVPLKAVEHHYLHTKPIE-GLSPDTPFVRDFDGRIFFRECEGHILAGGFER 332
            .||.|:|..::..|.:||.|.||.||.|:|:| .|...||.:.|.||||:.|..:|.||:||||:
Human   243 QWAYELGLSNEEPVSIPLHACEHFYLLTRPLETPLQSSTPTIVDADGRIYIRNWQGGILSGGFEK 307

  Fly   333 EAKMVYEDGVIPLSQTARQHPPDWDHFHELLDALLLRVPSFRDATLDRLTNSLQVFSPDCKWILG 397
            ..|.::.:|...|.....|.  |||||..||.:||.|:|......:.:|.|..:.|:||.:.|:|
Human   308 NPKPIFTEGKNQLEIQNLQE--DWDHFEPLLSSLLRRMPELETLEIMKLVNCPETFTPDMRCIMG 370

  Fly   398 EAPEIQNYYVAAGNKTMGVSASGGIGRVLTDLITKGSTYLDLHILDISRFLGLHNNRKFLRDRCK 462
            |:|.:|.|:|.||..:.|:|..||.|:.|.:.:..|....::..||:.||..|.::|.|||.|..
Human   371 ESPAVQGYFVLAGMNSAGLSFGGGAGKYLAEWMVHGYPSENVWELDLKRFGALQSSRTFLRHRVM 435

  Fly   463 EAPGKHFEINYPFEEFQTGRNLRMSPIYPQLKEAGAVFGQSMGYERPNYFDQQDKHDEFGLPRFR 527
            |.....:::..|..:|||||.||.||:|.:|...||.:.:..|:|||.||...||      ....
Human   436 EVMPLMYDLKVPRWDFQTGRQLRTSPLYDRLDAQGARWMEKHGFERPKYFVPPDK------DLLA 494

  Fly   528 IAQTRTFGKPPWFDHVASEYRACRERIGIADYSSFTKYDFWSKGNEVVDLLQYLCSNDVDVAVGS 592
            :.|::||.||.|||.|.||.:.|:|.:.:.|.|||||::..|.|::.:::||||.|||:||.||.
Human   495 LEQSKTFYKPDWFDIVESEVKCCKEAVCVIDMSSFTKFEITSTGDQALEVLQYLFSNDLDVPVGH 559

  Fly   593 IIHTGMQNPNGGYENDCSLARLSERHYMMIAPTIQQTRSMCWIRKHMPNHLRAKVNVADVTSMYT 657
            |:||||.|..||||||||:|||::|.:.||:||.||.....|::||||..  :.:.:.|||..||
Human   560 IVHTGMLNEGGGYENDCSIARLNKRSFFMISPTDQQVHCWAWLKKHMPKD--SNLLLEDVTWKYT 622

  Fly   658 AICILGPYSRILLSELTDTDLTPKSFPFFTYKELDVGLADGIRVLNITHTGELGYVLYIPNEYAL 722
            |:.::||.:..:||||:...:||..||....||:.||.|:||||:::|||||.|::||||.||||
Human   623 ALNLIGPRAVDVLSELSYAPMTPDHFPSLFCKEMSVGYANGIRVMSMTHTGEPGFMLYIPIEYAL 687

  Fly   723 HVYSRLYQAGQKFNIQHAGYYATRALRIEKFYAFWGQDLDTFTTPLECGRSWRVKFNKPIDFIGR 787
            |||:.:...|||:.|::|||||.|:||||||:||||||::..||||||||..|||..|.:|||||
Human   688 HVYNEVMSVGQKYGIRNAGYYALRSLRIEKFFAFWGQDINNLTTPLECGRESRVKLEKGMDFIGR 752

  Fly   788 NALLKQREEGVKRMYVQLLLNDHDHEVDMWCWGGEPIYRDGVYVGMTTTTGYGYTFEKQVCLGFV 852
            :|||:|::.||.:.....:|:|||.::|:|.|.||||||:|.|||.||::.|.|:.|:.||||||
Human   753 DALLQQKQNGVYKRLTMFILDDHDSDLDLWPWWGEPIYRNGQYVGKTTSSAYSYSLERHVCLGFV 817

  Fly   853 RNF-DDEGRELPVTNEYVLSGHYEVEVAGVRFEAKVNLHSPNLPTKFPDREREAYHATRDKPDQA 916
            .|| :|.|.|..||.:::..|.||:::||.||:||..|:.  :.:.|..:.|      :|..:.:
Human   818 HNFSEDTGEEQVVTADFINRGEYEIDIAGYRFQAKAKLYP--VASLFTQKRR------KDDMELS 874

  Fly   917 DL 918
            ||
Human   875 DL 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3626	NP_572162.2	DAO	70..429	CDD:279590	140/360 (39%)
		FAO_M	432..487	CDD:292961	20/54 (37%)
		GcvT	480..908	CDD:223481	214/428 (50%)
		GCV_T	490..774	CDD:279857	145/283 (51%)
		GCV_T_C	783..887	CDD:285832	54/104 (52%)
PDPR	NP_001309046.1	NADB_Rossmann	5..>74	CDD:304358	33/90 (37%)
		DadA	39..426	CDD:223737	148/389 (38%)
		FAO_M	405..460	CDD:292961	20/54 (37%)
		GcvT	453..830	CDD:223481	200/384 (52%)
		GCV_T	463..736	CDD:279857	142/280 (51%)
		GCV_T_C	748..852	CDD:285832	53/103 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	297	0.223	Domainoid score	I1462
eggNOG	1	0.900	-	-		E1_COG0404
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9948
Inparanoid	1	1.050	718	1.000	Inparanoid score	I639
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47999
OrthoDB	1	1.010	-	-		D137947at2759
OrthoFinder	1	1.000	-	-		FOG0002575
OrthoInspector	1	1.000	-	-		oto89875
orthoMCL	1	0.900	-	-		OOG6_106000
Panther	1	1.100	-	-	LDO	PTHR13847
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4385
SonicParanoid	1	1.000	-	-		X5511
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870