DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3626 and Sardh

DIOPT Version :9

Sequence 1:	NP_572162.2	Gene:	CG3626 / 31377	FlyBaseID:	FBgn0029706	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_611263.1	Gene:	Sardh / 37026	FlyBaseID:	FBgn0034276	Length:	894	Species:	Drosophila melanogaster

Alignment Length:	915	Identity:	243/915 - (26%)
Similarity:	413/915 - (45%)	Gaps:	97/915 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 MDPADERVLRKRKFQPQQAADLSEELAGQLPVKSRVVICGGGITGASVAYHLGLRGWGGETLLVE 100
            :..|..|.:.|   |.::......|.:|.||..:.||:.|||..|....|||..|  |.:.:|:|
  Fly     7 LQQASRRGISK---QVREDGGARREPSGFLPGAADVVVIGGGSAGCHTLYHLARR--GVKAVLLE 66

  Fly   101 QDRVGGELPWTACGLAGRFEPSYTELKLAEYSIDLIKRL-AENGLPTGWRPVGSLNLARSWDRMT 164
            :.::.....|...||..|..|:..:::|...|..::::| .|..|..||...|.:.:|.:..|:.
  Fly    67 RAQLTAGTTWHTAGLLWRLRPNDVDIQLLANSRRMLQQLEEETELDPGWIQNGGIFIAHNETRLD 131

  Fly   165 AFNRMKSQALAWGMHCEILSPEQCAQHCELLSLDGIEGGLWIPEDGVCDPQLVCQAYMIEAQRLG 229
            .:.|:.:...|.|:..::||||...:...||......|.|:.|.|||.||.::|.|....|..||
  Fly   132 EYRRLATVGSALGIENQVLSPEDTQKLFPLLDPSAFVGALYSPGDGVMDPAMLCAALKKAATNLG 196

  Fly   230 VRIVEHCAIKKIHSEH----GKVRSVETTAGDVECEYFVNCTGFWAREVGTLSKPVVKVPLKAVE 290
            .:::|:|.:..:..|.    .||..|.|..||::.|..||.||.|.|::  :::....:||..::
  Fly   197 AQVIENCGVDDLLLEQTARGKKVVGVSTPFGDIKAEKVVNATGVWGRDL--VARHGTHLPLVPMK 259

  Fly   291 HHYLHTKPIEGLSPDTPFVRDFDGRIFFRECEGHILAGGFEREAKMV------YEDGVIPLSQTA 349
            |.|:.::.|.|:. ..|.:||.|...:||.....|..||:|....::      :..|:..|
  Fly   260 HAYIVSESIPGVR-GLPNIRDHDYSTYFRIQGDAICMGGYEPNPILLEPVPKDFHFGLYEL---- 319

  Fly   350 RQHPPDWDHFHELLDALLLRVPSFRDATLDRLTNSLQVFSPDCKWILGEAPEIQNYYVAAGNKTM 414
                 ||..|...::......||:....:.......:.|:||.|.::|..|.:...|...|..:.
  Fly   320 -----DWSVFETHVEGAQKLCPSYAKYGVKSTVCGPESFTPDHKPLMGPDPNLDGLYHNCGFNSA 379

  Fly   415 GVSASGGIGRVLTDLITKGSTYLDLHILDISRFLGLHNNR-KFLRDRCKEAPGKHFEINYPFEEF 478
            |:...||.|......:.:|...|.:...|:.||....... :::|::..|:..|::.:.:.:::.
  Fly   380 GMMFGGGCGEQTALWVIQGQPDLPMFGFDLRRFTQEQGKAIQWIREKSHESYVKNYSMVFKYDQP 444

  Fly   479 QTGRNLRMSPIYPQLKEAGAVFGQSMGYERPNYF--------------------DQQDKHDEF-- 521
            ..||:.:..|::.::.:||||..:..|:|||.:|                    .|:.|..|:
  Fly   445 LAGRDFQKDPLHDEMMKAGAVMEEKQGWERPGFFLPTGSKKAVVQPYDWYGSYVHQRHKDSEYER 509

  Fly   522 ----GLPRFRIAQTRTFGKPPWFDHVASEYRACRERIGIADYSSFTKYDFWSKGNEVVDLLQYLC 582
                .|...|.::        :.|.:.||..|||....:.:.|.|.|  ....|.:..:...:|.
  Fly   510 VLDGDLHYSRFSE--------YHDLIGSEALACRNNAVVFNMSYFAK--LLLDGPQAQEAADWLF 564

  Fly   583 SNDVDVAVGSIIHTGMQNPNGGYENDCSLARLSERHYMMIAPTIQQT--------RSMCWIRKHM 639
            |.:.:......::|...|..||.|.|.:::||:.....:..|.|...        .|..:....:
  Fly   565 SANTNRDPSKTVYTCALNDAGGVEADVTISRLAPGSGEVYNPKINGQGFYIVAGGASAFYTYSVL 629

  Fly   640 PNHLRAK---VNVADVTSMYTAICILGPYSRILLSELTDTDLT-----PKSFPFFTYKELDVGLA 696
            ...:|.|   .::.|:|:....|.|.||.||.:|..|.|.||:     |.|.....:.::
  Fly   630 LAEIRRKGFNASLKDLTAELGVISIQGPNSRKILQPLIDCDLSDEHVAPNSTRLAKFGDV----- 689

  Fly   697 DGIRVLNITHTGELGYVLYIPNEYALHVYSRLYQAGQKFNIQHAGYYATRALRIEKFYAFWGQDL 761
             |:|:|.::..|||||.|::|.:....||..|.:||...::::|||.:..:|..||.|..|..||
  Fly   690 -GLRLLRVSFVGELGYELHVPKKDCAAVYRSLMKAGAGEDLRNAGYRSLYSLSSEKGYHLWSFDL 753

  Fly   762 DTFTTPLECGRSWRVKFNKPIDFIGRNALLKQREEGVKRMYVQLLLNDHDHEVDMWCWGGEPIYR 826
            ....||||.|..:..: ....|:.|:.|:..||.||:|:..|.|.|.|   :|.:  ||.|.:||
  Fly   754 RPDDTPLEAGLGFTCR-KTGADYRGKAAIENQRAEGLKKRLVYLTLRD---QVPI--WGLEGVYR 812

  Fly   827 DGVYVGMTTTTGYGYTFEKQVCLGFVRNFDDEGRELPVTNEYVLSGHYEVEVAGVRFEAKVNLHS 891
            :|..||:.....|.||..|.:...:|...|.:    .:..:|:.:|.|||::.|.::.|..:|.|
  Fly   813 NGEPVGILRRAEYAYTLGKSLGQTYVSRPDGK----IIDADYIRNGEYEVDILGKKYRADCHLRS 873

  Fly   892 PNLPT 896
            |..||
  Fly   874 PFDPT 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3626	NP_572162.2	DAO	70..429	CDD:279590	101/369 (27%)
		FAO_M	432..487	CDD:292961	10/55 (18%)
		GcvT	480..908	CDD:223481	126/459 (27%)
		GCV_T	490..774	CDD:279857	84/325 (26%)
		GCV_T_C	783..887	CDD:285832	34/103 (33%)
Sardh	NP_611263.1	DadA	33..412	CDD:223737	106/392 (27%)
		NADB_Rossmann	37..>76	CDD:304358	13/40 (33%)
		nuc_hydro	203..>281	CDD:294156	24/80 (30%)
		FAO_M	398..449	CDD:292961	9/50 (18%)
		GcvT	446..884	CDD:223481	126/459 (27%)
		GCV_T	456..767	CDD:279857	84/326 (26%)
		GCV_T_C	774..867	CDD:285832	33/101 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I4696
eggNOG	1	0.900	-	-		E1_COG0404
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16082at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13847
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.920