DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3626 and Pdpr

DIOPT Version :9

Sequence 1:	NP_572162.2	Gene:	CG3626 / 31377	FlyBaseID:	FBgn0029706	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_001100900.1	Gene:	Pdpr / 307852	RGDID:	1308307	Length:	878	Species:	Rattus norvegicus

Alignment Length:	918	Identity:	387/918 - (42%)
Similarity:	561/918 - (61%)	Gaps:	52/918 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VSVVPRRRWCSPGLS--NAVRLSSSQMDPADERVLRKRKFQPQQAADLSEELAGQLPVKSRVVIC 74
            :|:|.|:| .|||..  ::.|.|:|                   ||: ::.:|  ||.:::||||
  Rat     6 LSIVQRQR-TSPGWQTWSSARSSTS-------------------AAE-AQSIA--LPAQAQVVIC 47

  Fly    75 GGGITGASVAYHLGLRGWGGETLLVEQDRVGGELPWTACGLAGRFEPSYTELKLAEYSIDLIKRL 139
            ||||.|.||||||...|| .:.:|:||.|:.........|:......|..|.|:|:||..|..:|
  Rat    48 GGGIMGTSVAYHLSKMGW-QDIVLLEQGRLAAGSTRFCAGILSTARHSSIEQKMADYSNKLYHQL 111

  Fly   140 -AENGLPTGWRPVGSLNLARSWDRMTAFNRMKSQALAWGMHCEILSPEQCAQHCELLSLDGIEGG 203
             .|.|:.||:...||::||::.||:.:..|:.|:....|:..||:||::.|:...||::..:.|.
  Rat   112 EQETGIQTGYLRTGSISLAQTQDRLISLKRINSRLNVVGIPSEIISPKKVAELHPLLNVHDLVGA 176

  Fly   204 LWIPEDGVCDPQLVCQAYMIEAQRLGVRIVEHCAIKKIHSEHGKVRSVETTAGDVECEYFVNCTG 268
            :.:|||.|.....|..|....|.:.||:|.:..::..:.::.|:|..|:|..|.:||:|||||.|
  Rat   177 MHVPEDAVVSSADVALALASAASQNGVQIYDRTSVLHVLTKKGRVTGVDTDKGQIECQYFVNCAG 241

  Fly   269 FWAREVGTLSKPVVKVPLKAVEHHYLHTKPIEG-LSPDTPFVRDFDGRIFFRECEGHILAGGFER 332
            .||.|:|..|:..|.:||.|.||.||.|:|.:. |...||.|.|.||||:.|..:|.:|:||||:
  Rat   242 QWAYELGLSSEEPVSIPLHACEHFYLLTRPCDAPLQSSTPTVVDADGRIYIRNWQGGVLSGGFEK 306

  Fly   333 EAKMVYEDGVIPLS-QTARQHPPDWDHFHELLDALLLRVPSFRDATLDRLTNSLQVFSPDCKWIL 396
            ..|.::.:|...|. |..|:   |||||..||.:||.|:|......:.:|.|..:.|:.|.|.|:
  Rat   307 NPKPIFTEGKNQLEIQNLRE---DWDHFEPLLSSLLRRMPGLESVEILKLVNCPETFTADMKCIM 368

  Fly   397 GEAPEIQNYYVAAGNKTMGVSASGGIGRVLTDLITKGSTYLDLHILDISRFLGLHNNRKFLRDRC 461
            ||:|.:|.|:|.||..:.|:|..||.|::|.:.:..|....::..||:.||..|..:|.|||.|.
  Rat   369 GESPVVQGYFVLAGMNSAGLSLGGGAGKLLAEWMVYGYPSENVWELDLQRFGALQGSRTFLRHRV 433

  Fly   462 KEAPGKHFEINYPFEEFQTGRNLRMSPIYPQLKEAGAVFGQSMGYERPNYFDQQDKHDEFGLPRF 526
            .|.....:::..|..:|||||.||.||:|.:|...||.:.:..|:|||.||...:|      ...
  Rat   434 MEVMPLIYDLKVPRWDFQTGRQLRTSPLYDRLDAQGARWMEKHGFERPKYFVPPNK------DLL 492

  Fly   527 RIAQTRTFGKPPWFDHVASEYRACRERIGIADYSSFTKYDFWSKGNEVVDLLQYLCSNDVDVAVG 591
            .:.|::||.||.|||.|.||.:.|:|.:.:.|.|||||::..|.|::.::.||||.|||:||.||
  Rat   493 ALEQSKTFYKPDWFDIVESEVKCCKEAVCVIDMSSFTKFEITSTGDQALESLQYLFSNDLDVPVG 557

  Fly   592 SIIHTGMQNPNGGYENDCSLARLSERHYMMIAPTIQQTRSMCWIRKHMPNHLRAKVNVADVTSMY 656
            .|:||||.|..||:|||||:|||::|.:.||:||.||.....|:.|::|..  :.:.:.|||..|
  Rat   558 HIVHTGMLNEYGGHENDCSIARLTKRSFFMISPTDQQVHCWAWLHKYLPKD--SNLLLEDVTWKY 620

  Fly   657 TAICILGPYSRILLSELTDTDLTPKSFPFFTYKELDVGLADGIRVLNITHTGELGYVLYIPNEYA 721
            ||:.::||.:..:||||:...:||..||....||:.||.|:||||:::|||||.|::||||.|||
  Rat   621 TALNLIGPRAVDVLSELSYAPMTPDHFPTLFCKEMSVGYANGIRVMSMTHTGEPGFMLYIPIEYA 685

  Fly   722 LHVYSRLYQAGQKFNIQHAGYYATRALRIEKFYAFWGQDLDTFTTPLECGRSWRVKFNKPIDFIG 786
            ||||:.:...|||:.|::|||||.|:||||||:|||||||:|.|||||||...|||..|.|||||
  Rat   686 LHVYNEVMSVGQKYGIRNAGYYALRSLRIEKFFAFWGQDLNTLTTPLECGGESRVKLEKGIDFIG 750

  Fly   787 RNALLKQREEGVKRMYVQLLLNDHDHEVDMWCWGGEPIYRDGVYVGMTTTTGYGYTFEKQVCLGF 851
            |:|||:|::.||.:..|..:|:|||.::|:|.|.||||||:|.|.|.||::.|.||.|:.||||:
  Rat   751 RDALLQQKQTGVYKRLVMFILDDHDTDLDLWPWWGEPIYRNGKYAGKTTSSAYSYTLERHVCLGY 815

  Fly   852 VRNF-DDEGRELPVTNEYVLSGHYEVEVAGVRFEAKVNLHSPNLPTKFPDREREAYHATRDKPDQ 915
            |.|| :|.|.|..||.:::..|.||:::||.||:||..|:.   .|.|...:|        :.|.
  Rat   816 VHNFSEDSGEEQVVTADFINRGEYEIDIAGHRFQAKAKLYP---VTSFFTHKR--------RKDD 869

  Fly   916 ADLLSYGG 923
            .:|..:.|
  Rat   870 VELSDFHG 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3626	NP_572162.2	DAO	70..429	CDD:279590	141/361 (39%)
		FAO_M	432..487	CDD:292961	20/54 (37%)
		GcvT	480..908	CDD:223481	213/428 (50%)
		GCV_T	490..774	CDD:279857	142/283 (50%)
		GCV_T_C	783..887	CDD:285832	54/104 (52%)
Pdpr	NP_001100900.1	DAO	44..384	CDD:279590	135/343 (39%)
		FAO_M	405..459	CDD:292961	20/53 (38%)
		GcvT	452..867	CDD:223481	213/433 (49%)
		GCV_T	462..735	CDD:279857	140/280 (50%)
		GCV_T_C	747..851	CDD:285832	53/103 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	290	1.000	Domainoid score	I1492
eggNOG	1	0.900	-	-		E1_COG0404
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9948
Inparanoid	1	1.050	709	1.000	Inparanoid score	I620
OMA	1	1.010	-	-		QHG47999
OrthoDB	1	1.010	-	-		D137947at2759
OrthoFinder	1	1.000	-	-		FOG0002575
OrthoInspector	1	1.000	-	-		oto96992
orthoMCL	1	0.900	-	-		OOG6_106000
Panther	1	1.100	-	-	LDO	PTHR13847
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5511
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840