Protein Alignment CG3626 and DMGDH

DIOPT Version :10

• Sequence 1: NP_572162.2
• Gene: CG3626 / 31377
• FlyBaseID: FBgn0029706
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: NP_037523.2
• Gene: DMGDH / 29958
• HGNCID: 24475
• Length: 866
• Species: Homo sapiens
• Alignment Length: 886
• Identity: 263/886 - (29%)
• Similarity: 420/886 - (47%)
• Gaps: 80/886 - (9%)

  Fly    52 QQAADLSEELAGQLPVKSRVVICGGGITGASVAYHLGLRGWGGETLLVEQDRVGGELPWTACGLA 116
            ::...||.|.  |...::..||.|||..|.|:||||...|.....||.:.:...|. .|.|.||.
Human    35 EEKPPLSAET--QWKDRAETVIIGGGCVGVSLAYHLAKAGMKDVVLLEKSELTAGS-TWHAAGLT 96

  Fly   117 GRFEPSYTELKLAEYSIDLIKRL-AENGLPTGWRPVGSLNLARSWDRMTAFNRMKSQALAWGMHC 180
            ..|.|.....|:...||.|.::| .|.|...|:...||:.||.:..|:..|   |.|....|.|.
Human    97 TYFHPGINLKKIHYDSIKLYEKLEEETGQVVGFHQPGSIRLATTPVRVDEF---KYQMTRTGWHA 158

  Fly   181 E---ILSPEQCAQHCELLSLDGIEGGLWIPEDGVCDPQLVCQAYMIEAQRLGVRIVEHCAIKKIH 242
            .   ::.||:..:...||:::.:..||:.|.||..||..:..|....|::.|..:.....:..:.
Human   159 TEQYLIEPEKIQEMFPLLNMNKVLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLK 223

  Fly   243 SEHGKVRSVETTAGDVECEYFVNCTGFWAREVGTLSKPVVKVPLKAVEHHYLHTKPI---EGLSP 304
            :.......|||..|.:.....||..||||||||.:..  ::.||..|:|.|:.|..|   :.|..
Human   224 ARSDGTWDVETPQGSMRANRIVNAAGFWAREVGKMIG--LEHPLIPVQHQYVVTSTISEVKALKR 286

  Fly   305 DTPFVRDFDGRIFFRECEGHILAGGFEREAKMVYEDGVIPLSQTARQHPP---------DWDHFH 360
            :.|.:||.:|..:.|:....:|.|.:|.:.||..:|     |......||         |.|...
Human   287 ELPVLRDLEGSYYLRQERDGLLFGPYESQEKMKVQD-----SWVTNGVPPGFGKELFESDLDRIM 346

  Fly   361 ELLDALLLRVPSFRDATLDRLTNSLQVFSPDCKWILGEAPEIQNYYVAAGNKTMGVSASGGIGRV 425
            |.:.|.:..||..:.|.:..:.|....:|||...::|....::||:||.| ...|:..:||:|:.
Human   347 EHIKAAMEMVPVLKKADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIG-FGYGIIHAGGVGKY 410

  Fly   426 LTDLITKGSTYLDLHILDISRFLGLHNNRKFLRDRCKEAPGKHFEINYPFEEFQTGR-NLRMSPI 489
            |:|.|..|....||..||.:|: |.....::...:.:|:.|.:..:.||.||...|| ..|:|.:
Human   411 LSDWILHGEPPFDLIELDPNRY-GKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGL 474

  Fly   490 YPQLKEAGAVFGQSMGYERPNYFDQQDKHDEFGLPRFRIAQTRTFGKPPWFDHVASEYRACRERI 554
            |.:| |:....|...|:|:|::|.:..:..:: .|.||        :..||:.|.|||:...:|:
Human   475 YQRL-ESKCSMGFHAGWEQPHWFYKPGQDTQY-RPSFR--------RTNWFEPVGSEYKQVMQRV 529

  Fly   555 GIADYSSFTKYDFWSKGNEVVDLLQYLCSNDV-DVAVGSIIHTGMQNPNGGYENDCSLARLSERH 618
            .:.|.|.|.|::.  ||.:.:.||.:|.:|.: .|...:|.|  |..|.|....:.:::..|...
Human   530 AVTDLSPFGKFNI--KGQDSIRLLDHLFANVIPKVGFTNISH--MLTPKGRVYAELTVSHQSPGE 590

  Fly   619 YMMIAPTIQQTRSMCWIRKHMPNHLRAK----VNVADVTSMYTAICILGPYSRILLSELTDTDLT 679
            :::|..:..:...:.||.:.     ..|    |.:.::|.....:.:.||.:|.:|.:||..||:
Human   591 FLLITGSGSELHDLRWIEEE-----AVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLS 650

  Fly   680 PKSFPFFTYKELDVGLADGIRVLNITHTGELGYVLYIPNEYALHVYSRLYQAGQKFNIQHAGYYA 744
            ...|.|...|.|.|.... :..:.|::|||||:.||...|.::.:|..:..|||:..|.:.|.||
Human   651 DDVFKFLQTKSLKVSNIP-VTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYA 714

  Fly   745 TRALRIEKFYAFWGQDLDTFTTPLECGRSWRVKFNKPIDFIGRNALLKQREEGVKRMYVQLLL-- 807
            ..|||:||.:..||.:::..|.|||.|..:.||.|||.||||:.||.:.:.:|:||..|.|.|
Human   715 MNALRLEKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVCLTLAT 779

  Fly   808 NDHDHEVDMWCWGGEPIYRDGVYVGMTTTTGYGYTFEKQVCLGFVR-NFDDEGRELPVTNEYVLS 871
            :|.|.|      |.|.|:.:|..||.||:..|.|:.:|.:...:|. ...:.|:::
Human   780 DDVDPE------GNESIWYNGKVVGNTTSGSYSYSIQKSLAFAYVPVQLSEVGQQV--------- 829

  Fly   872 GHYEVEVAGVRFEAKVNLHSPNLPTKFPDREREAYHATRDK 912
               |||:.|..:.| |.:..|.:.|: |.|.|......:||
Human   830 ---EVELLGKNYPA-VIIQEPLVLTE-PTRNRLQKKGGKDK 865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3626	NP_572162.2	DadA	70..446	CDD:440429	118/391 (30%)
		FAO_M	432..487	CDD:465100	16/55 (29%)
		GcvT	481..904	CDD:440173	130/431 (30%)
DMGDH	NP_037523.2	DadA	49..431	CDD:440429	118/393 (30%)
		FAO_M	417..472	CDD:465100	16/55 (29%)
		GcvT	465..857	CDD:440173	130/431 (30%)