DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3626 and DMGDH

DIOPT Version :9

Sequence 1:	NP_572162.2	Gene:	CG3626 / 31377	FlyBaseID:	FBgn0029706	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_037523.2	Gene:	DMGDH / 29958	HGNCID:	24475	Length:	866	Species:	Homo sapiens

Alignment Length:	886	Identity:	263/886 - (29%)
Similarity:	420/886 - (47%)	Gaps:	80/886 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 QQAADLSEELAGQLPVKSRVVICGGGITGASVAYHLGLRGWGGETLLVEQDRVGGELPWTACGLA 116
            ::...||.|.  |...::..||.|||..|.|:||||...|.....||.:.:...|. .|.|.||.
Human    35 EEKPPLSAET--QWKDRAETVIIGGGCVGVSLAYHLAKAGMKDVVLLEKSELTAGS-TWHAAGLT 96

  Fly   117 GRFEPSYTELKLAEYSIDLIKRL-AENGLPTGWRPVGSLNLARSWDRMTAFNRMKSQALAWGMHC 180
            ..|.|.....|:...||.|.::| .|.|...|:...||:.||.:..|:..|   |.|....|.|.
Human    97 TYFHPGINLKKIHYDSIKLYEKLEEETGQVVGFHQPGSIRLATTPVRVDEF---KYQMTRTGWHA 158

  Fly   181 E---ILSPEQCAQHCELLSLDGIEGGLWIPEDGVCDPQLVCQAYMIEAQRLGVRIVEHCAIKKIH 242
            .   ::.||:..:...||:::.:..||:.|.||..||..:..|....|::.|..:.....:..:.
Human   159 TEQYLIEPEKIQEMFPLLNMNKVLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLK 223

  Fly   243 SEHGKVRSVETTAGDVECEYFVNCTGFWAREVGTLSKPVVKVPLKAVEHHYLHTKPI---EGLSP 304
            :.......|||..|.:.....||..||||||||.:..  ::.||..|:|.|:.|..|   :.|..
Human   224 ARSDGTWDVETPQGSMRANRIVNAAGFWAREVGKMIG--LEHPLIPVQHQYVVTSTISEVKALKR 286

  Fly   305 DTPFVRDFDGRIFFRECEGHILAGGFEREAKMVYEDGVIPLSQTARQHPP---------DWDHFH 360
            :.|.:||.:|..:.|:....:|.|.:|.:.||..:|     |......||         |.|...
Human   287 ELPVLRDLEGSYYLRQERDGLLFGPYESQEKMKVQD-----SWVTNGVPPGFGKELFESDLDRIM 346

  Fly   361 ELLDALLLRVPSFRDATLDRLTNSLQVFSPDCKWILGEAPEIQNYYVAAGNKTMGVSASGGIGRV 425
            |.:.|.:..||..:.|.:..:.|....:|||...::|....::||:||.| ...|:..:||:|:.
Human   347 EHIKAAMEMVPVLKKADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIG-FGYGIIHAGGVGKY 410

  Fly   426 LTDLITKGSTYLDLHILDISRFLGLHNNRKFLRDRCKEAPGKHFEINYPFEEFQTGR-NLRMSPI 489
            |:|.|..|....||..||.:|: |.....::...:.:|:.|.:..:.||.||...|| ..|:|.:
Human   411 LSDWILHGEPPFDLIELDPNRY-GKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGL 474

  Fly   490 YPQLKEAGAVFGQSMGYERPNYFDQQDKHDEFGLPRFRIAQTRTFGKPPWFDHVASEYRACRERI 554
            |.:| |:....|...|:|:|::|.:..:..:: .|.||        :..||:.|.|||:...:|:
Human   475 YQRL-ESKCSMGFHAGWEQPHWFYKPGQDTQY-RPSFR--------RTNWFEPVGSEYKQVMQRV 529

  Fly   555 GIADYSSFTKYDFWSKGNEVVDLLQYLCSNDV-DVAVGSIIHTGMQNPNGGYENDCSLARLSERH 618
            .:.|.|.|.|::.  ||.:.:.||.:|.:|.: .|...:|.|  |..|.|....:.:::..|...
Human   530 AVTDLSPFGKFNI--KGQDSIRLLDHLFANVIPKVGFTNISH--MLTPKGRVYAELTVSHQSPGE 590

  Fly   619 YMMIAPTIQQTRSMCWIRKHMPNHLRAK----VNVADVTSMYTAICILGPYSRILLSELTDTDLT 679
            :::|..:..:...:.||.:.     ..|    |.:.::|.....:.:.||.:|.:|.:||..||:
Human   591 FLLITGSGSELHDLRWIEEE-----AVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLS 650

  Fly   680 PKSFPFFTYKELDVGLADGIRVLNITHTGELGYVLYIPNEYALHVYSRLYQAGQKFNIQHAGYYA 744
            ...|.|...|.|.|.... :..:.|::|||||:.||...|.::.:|..:..|||:..|.:.|.||
Human   651 DDVFKFLQTKSLKVSNIP-VTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYA 714

  Fly   745 TRALRIEKFYAFWGQDLDTFTTPLECGRSWRVKFNKPIDFIGRNALLKQREEGVKRMYVQLLL-- 807
            ..|||:||.:..||.:::..|.|||.|..:.||.|||.||||:.||.:.:.:|:||..|.|.|
Human   715 MNALRLEKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVCLTLAT 779

  Fly   808 NDHDHEVDMWCWGGEPIYRDGVYVGMTTTTGYGYTFEKQVCLGFVR-NFDDEGRELPVTNEYVLS 871
            :|.|.|      |.|.|:.:|..||.||:..|.|:.:|.:...:|. ...:.|:::
Human   780 DDVDPE------GNESIWYNGKVVGNTTSGSYSYSIQKSLAFAYVPVQLSEVGQQV--------- 829

  Fly   872 GHYEVEVAGVRFEAKVNLHSPNLPTKFPDREREAYHATRDK 912
               |||:.|..:.| |.:..|.:.|: |.|.|......:||
Human   830 ---EVELLGKNYPA-VIIQEPLVLTE-PTRNRLQKKGGKDK 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3626	NP_572162.2	DAO	70..429	CDD:279590	111/374 (30%)
		FAO_M	432..487	CDD:292961	16/55 (29%)
		GcvT	480..908	CDD:223481	131/436 (30%)
		GCV_T	490..774	CDD:279857	83/288 (29%)
		GCV_T_C	783..887	CDD:285832	33/106 (31%)
DMGDH	NP_037523.2	NADB_Rossmann	44..>90	CDD:304358	16/48 (33%)
		DadA	47..435	CDD:223737	120/400 (30%)
		FAO_M	417..472	CDD:292961	16/55 (29%)
		GcvT	464..857	CDD:223481	130/432 (30%)
		GCV_T	482..745	CDD:279857	80/281 (28%)
		GCV_T_C	753..845	CDD:285832	34/110 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D96522at33208
OrthoFinder	1	1.000	-	-		FOG0002575
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820