DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3626 and Dmgdh

DIOPT Version :9

Sequence 1:	NP_572162.2	Gene:	CG3626 / 31377	FlyBaseID:	FBgn0029706	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	XP_038957650.1	Gene:	Dmgdh / 245961	RGDID:	620453	Length:	884	Species:	Rattus norvegicus

Alignment Length:	916	Identity:	270/916 - (29%)
Similarity:	427/916 - (46%)	Gaps:	96/916 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LSSSQMDPADERVLRKRKFQPQQA----ADLSEELAGQLPVKSR---------------VVICGG 76
            |.|||..|:...:.....|:...|    ||......|: |..||               .||.||
  Rat    14 LRSSQGRPSSAGLREGTVFELYPAILSSADFCHGACGK-PAYSRQESPPSPPEWKDRAETVIIGG 77

  Fly    77 GITGASVAYHLGLRGWGGETLLVEQDRVGGELPWTACGLAGRFEPSYTELKLAEYSIDLIKRL-A 140
            |..|.|:||||...|.....||.:.:...|. .|.|.||...|.|.....|:...||.|.:|| .
  Rat    78 GCVGVSLAYHLAKAGMRDVVLLEKSELTAGS-TWHAAGLTTYFHPGINLKKIHYDSIKLYERLEE 141

  Fly   141 ENGLPTGWRPVGSLNLARSWDRMTAFNRMKSQALAWGMHCE---ILSPEQCAQHCELLSLDGIEG 202
            |.|...|:...||:.||.:.:|:..|   |.|......|..   |:.||:..:...||::|.|..
  Rat   142 ETGQVVGFHQPGSIRLATTPERVDEF---KYQMTRTNWHATEQYIIEPEKIHELFPLLNMDKILA 203

  Fly   203 GLWIPEDGVCDPQLVCQAYMIEAQRLGVRIVEHCAIKKIHSEHGKVRSVETTAGDVECEYFVNCT 267
            ||:.|.||..||..:..|....|::.|..:.....:..:.........|||..|.|.....||..
  Rat   204 GLYNPGDGHIDPYSLTMALATGARKYGALLKYPAPVTSLKPRPDGTWDVETPQGSVRANRIVNAA 268

  Fly   268 GFWAREVGTLSKPVVKVPLKAVEHHYLHTKPI---EGLSPDTPFVRDFDGRIFFRECEGHILAGG 329
            ||||||||.:..  :..||..|:|.|:.|..|   :.|..:.|.:||.:|..:.|:....:|.|.
  Rat   269 GFWAREVGKMIG--LDHPLIPVQHQYVITSTIPEVKALKRELPVLRDLEGSYYLRQERDGLLFGP 331

  Fly   330 FEREAKMVYEDGVIPLSQTARQHPP---------DWDHFHELLDALLLRVPSFRDATLDRLTNSL 385
            :|.:.||     .:..|..|...||         |.|...|.::|.:..||..:.|.:..:.|..
  Rat   332 YESQEKM-----KLQASWVAHGVPPGFGKELFESDLDRITEHVEAAMEMVPVLKKADIINIVNGP 391

  Fly   386 QVFSPDCKWILGEAPEIQNYYVAAGNKTMGVSASGGIGRVLTDLITKGSTYLDLHILDISRFLGL 450
            ..:|||...::|....::||:||.| ...|:..:||:|..|:|.|..|....||..||.:|: |.
  Rat   392 ITYSPDILPMVGPHQGVRNYWVAIG-FGYGIIHAGGVGTYLSDWILHGEPPFDLIELDPNRY-GK 454

  Fly   451 HNNRKFLRDRCKEAPGKHFEINYPFEEFQTGR-NLRMSPIYPQLKEAGAVFGQSMGYERPNYFDQ 514
            ....::...:.:|:.|.:..:.||.||...|| ..|:|.:| ::.|:....|...|:|:|::|.:
  Rat   455 WTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLY-KILESKCSMGFHAGWEQPHWFYK 518

  Fly   515 QDKHDEFGLPRFRIAQTRTFGKPPWFDHVASEYRACRERIGIADYSSFTKYDFWSKGNEVVDLLQ 579
            ..:..:: .|.||        :..||:.|.|||:...:|:|:.|.|.|.|::.  ||.:...||.
  Rat   519 PGQDTQY-RPSFR--------RTNWFEPVGSEYKQVMQRVGVIDLSPFGKFNI--KGQDSTQLLD 572

  Fly   580 YLCSNDV-DVAVGSIIHTGMQNPNGGYENDCSLARLSERHYMMIAPTIQQTRSMCWIRKHMPNHL 643
            :||:|.: .|...:|.|  |..|.|....:.:::..|...:::|..:..:...:.||.:..   :
  Rat   573 HLCANVIPKVGFTNISH--MLTPRGRVYAELTVSHQSPGEFLLITGSGSELHDLRWIEEAA---V 632

  Fly   644 RA--KVNVADVTSMYTAICILGPYSRILLSELTDTDLTPKSFPFFTYKELDVGLAD-GIRVLNIT 705
            |.  .|.:.::|.....:.:.|||:|.:|.:||..||:...|.|...|.|.:  :| .:..:.|:
  Rat   633 RGGYDVEIRNITDELGVLGVAGPYARRVLQKLTSEDLSDDVFKFLQTKSLKI--SDIPVTAIRIS 695

  Fly   706 HTGELGYVLYIPNEYALHVYSRLYQAGQKFNIQHAGYYATRALRIEKFYAFWGQDLDTFTTPLEC 770
            :|||||:.||...|.:..:|.|:..|||:..|.:.|.||..|||:||.:..||.:::..|.|||.
  Rat   696 YTGELGWELYHRREDSAALYERIMNAGQEEGIDNFGTYALNALRLEKAFRAWGSEMNCDTNPLEA 760

  Fly   771 GRSWRVKFNKPIDFIGRNALLKQREEGVKRMYVQLLL--NDHDHEVDMWCWGGEPIYRDGVYVGM 833
            |..:.:|.|||.:|.|:.||.:.:.:|:||..|.|.|  ::.|.|      |.|.::..|..:|.
  Rat   761 GLDYFIKLNKPANFTGKQALKQIKAKGLKRRLVCLTLATDNVDPE------GNESVWYKGKVIGN 819

  Fly   834 TTTTGYGYTFEKQVCLGFVR-NFDDEGRELPVTNEYVLSGHYEVEVAGVRFEAKVNLHSPNLPTK 897
            ||:..|.|:.:|.:...:|. ...:.|:::            |||:.|..:.|.: :..|.:.|:
  Rat   820 TTSGSYSYSIQKSLAFAYVPVELSEVGQQV------------EVELLGKNYPATI-IQEPLVLTE 871

  Fly   898 FPDRER 903
             |.|.|
  Rat   872 -PTRTR 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3626	NP_572162.2	DAO	70..429	CDD:279590	116/389 (30%)
		FAO_M	432..487	CDD:292961	16/55 (29%)
		GcvT	480..908	CDD:223481	127/432 (29%)
		GCV_T	490..774	CDD:279857	86/287 (30%)
		GCV_T_C	783..887	CDD:285832	28/106 (26%)
Dmgdh	XP_038957650.1	DadA	67..455	CDD:223737	124/400 (31%)
		FAO_M	437..492	CDD:406692	16/55 (29%)
		GcvT	508..877	CDD:223481	120/407 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D96522at33208
OrthoFinder	1	1.000	-	-		FOG0002575
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820