DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3626 and SARDH

DIOPT Version :9

Sequence 1:	NP_572162.2	Gene:	CG3626 / 31377	FlyBaseID:	FBgn0029706	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_001128179.1	Gene:	SARDH / 1757	HGNCID:	10536	Length:	918	Species:	Homo sapiens

Alignment Length:	945	Identity:	288/945 - (30%)
Similarity:	459/945 - (48%)	Gaps:	99/945 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LQRSGNAVSVVPRRRWCSP--GLSNAVRLSSSQMDPADERVLRKRKFQPQQAAD-LSEELAGQLP 66
            |.|:....:..||:   ||  |: ....|||:....|::.|..:|..:..|... :::..:..||
Human     4 LSRALRVAAAHPRQ---SPTRGM-GPCNLSSAAGPTAEKSVPYQRTLKEGQGTSVVAQGPSRPLP 64

  Fly    67 VKSRVVICGGGITGASVAYHLGLRGWGGETLLVEQDRVGGELPWTACGLAGRFEPSYTELKLAEY 131
            ..:.||:.|||..|....|||...|..|..|| |::|:.....|...||..:..||..|::|..:
Human    65 STANVVVIGGGSLGCQTLYHLAKLGMSGAVLL-ERERLTSGTTWHTAGLLWQLRPSDVEVELLAH 128

  Fly   132 SIDLIKR--LAENGLPTGWRPVGSLNLARSWDRMTAFNRMKSQALAWGMHCEILSPEQCAQHCEL 194
            :..::.|  ..|.||.|||...|.|.:|.:..|:..:.|:.|...|:|:...:|||.:......|
Human   129 TRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPL 193

  Fly   195 LSLDGIEGGLWIPEDGVCDPQLVCQAYMIEAQRLGVRIVEHCAIKKIH---SEHG--KVRSVETT 254
            :::|.:.|.|::|.||..||...|......|...|.:::|:|.:..|.   .:.|  :|..|||.
Human   194 MNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIRVWTDDFGVRRVAGVETQ 258

  Fly   255 AGDVECEYFVNCTGFWAREVGTLSKPVVKVPLKAVEHHYLHTKPIEGLSPDTPFVRDFDGRIFFR 319
            .|.::....|||.|.||..||.::.  |||||.|:.|.|:.|:.|||:. :.|.|||.|..::.|
Human   259 HGSIQTPCVVNCAGVWASAVGRMAG--VKVPLVAMHHAYVVTERIEGIQ-NMPNVRDHDASVYLR 320

  Fly   320 ECEGHILA-GGFE------REAKMVYEDGVIPLSQTARQHPPDWDHFHELLDALLLRVPSFRDAT 377
             .:|..|: ||:|      .|....:..|:..|         ||:.|.:.::..:.|||......
Human   321 -LQGDALSVGGYEANPIFWEEVSDKFAFGLFDL---------DWEVFTQHIEGAINRVPVLEKTG 375

  Fly   378 LDRLTNSLQVFSPDCKWILGEAPEIQNYYVAAGNKTMGVSASGGIGRVLTDLITKGSTYLDLHIL 442
            :.......:.|:||.|.::|||||::.:::..|..:.|:...||.|:.|...|..|....|:|..
Human   376 IKSTVCGPESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGY 440

  Fly   443 DISRF-LGLHNNRKFLRDRCKEAPGKHFEINYPFEEFQTGRNLRMSPIYPQLKEAGAVFGQSMGY 506
            ||.|| ..|.::.:::|:|..|:..|::.:.:|.:|...|||:|..|::.:|...|.||.:..|:
Human   441 DIRRFHHSLTDHPRWIRERSHESYAKNYSVVFPHDEPLAGRNMRRDPLHEELLGQGCVFQERHGW 505

  Fly   507 ERPNYFDQQD----------------KHDEFGLPRFRIAQTRTFGKPPWFDHVASEYRACRERIG 555
            |||.:|..:.                .|:::...|. :|...||..||..|.:..|..|||....
Human   506 ERPGWFHPRGPAPVLEYDYYGAYGSRAHEDYAYRRL-LADEYTFAFPPHHDTIKKECLACRGAAA 569

  Fly   556 IADYSSFTKYDFWSKGNEVVDLLQYLCSNDVDVAVGSIIHTGMQNPNGGYENDCSLARLSERH-- 618
            :.|.|.|.|  |:..|.:......:|.|.||....||.::|.|.|..||.|:|.:::||:..|
Human   570 VFDMSYFGK--FYLVGLDARKAADWLFSADVSRPPGSTVYTCMLNHRGGTESDLTVSRLAPSHQA 632

  Fly   619 ------------YMMIAPTIQQTRSMCWIRKHMPNHL-------RAKVNVADVTSMYTAICILGP 664
                        |:.:...:.|         |..:|:       :::..:.|.:.....|.|.||
Human   633 SPLAPAFEGDGYYLAMGGAVAQ---------HNWSHITTVLQDQKSQCQLIDSSEDLGMISIQGP 688

  Fly   665 YSRILLSELTDTDLTPKSFPFFTYKELDVGLADG--IRVLNITHTGELGYVLYIPNEYALHVYSR 727
            .||.:|.|:.|.||:.::|||.|:|.|   .|.|  :|.:.::..||||:.|:||....:.||..
Human   689 ASRAILQEVLDADLSNEAFPFSTHKLL---RAAGHLVRAMRLSFVGELGWELHIPKASCVPVYRA 750

  Fly   728 LYQAGQKFNIQHAGYYATRALRIEKFYAFWGQDLDTFTTPLECGRSWRVKFNKPIDFIGRNALLK 792
            :..||.|..:.:|||.|..:|.|||.|..|..||....:|||.|.::..|...|:.|:||.||.:
Human   751 VMAAGAKHGLINAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQ 815

  Fly   793 QREEGVKRMYVQLLLNDHDHEVDMWCWGGEPIYRDGVYVGMTTTTGYGYTFEKQVCLGFVRNFDD 857
            ||..|::|..|...:.|   :|.|  :|.|.|:|:|..||......:|:..:|.:..|::.  |.
Human   816 QRAAGLRRRLVCFTMED---KVPM--FGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYIH--DP 873

  Fly   858 EGRELPVTNEYVLSGHYEVEVAGVRFEAKVNLHSP 892
            .|.  ||:.::|.||.|.:|..||.:.|:.:|.||
Human   874 SGG--PVSLDFVKSGDYALERMGVTYGAQAHLKSP 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3626	NP_572162.2	DAO	70..429	CDD:279590	116/372 (31%)
		FAO_M	432..487	CDD:292961	18/55 (33%)
		GcvT	480..908	CDD:223481	141/452 (31%)
		GCV_T	490..774	CDD:279857	96/322 (30%)
		GCV_T_C	783..887	CDD:285832	35/103 (34%)
SARDH	NP_001128179.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		11/39 (28%)
		DadA	63..447	CDD:223737	126/397 (32%)
		FAO_M	430..485	CDD:292961	17/54 (31%)
		GcvT	479..916	CDD:223481	141/452 (31%)
		GCV_T	489..798	CDD:279857	96/323 (30%)
		GCV_T_C	807..>871	CDD:285832	23/68 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D96522at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820