DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3626 and Y37E3.17

DIOPT Version :9

Sequence 1:	NP_572162.2	Gene:	CG3626 / 31377	FlyBaseID:	FBgn0029706	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_001360456.1	Gene:	Y37E3.17 / 171775	WormBaseID:	WBGene00021355	Length:	840	Species:	Caenorhabditis elegans

Alignment Length:	885	Identity:	223/885 - (25%)
Similarity:	388/885 - (43%)	Gaps:	102/885 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 AADLSEELAGQLPVKSRVVIC--GGGITGASVAYHLGLRGWGGETLLVEQDRVG----------G 106
            ::||...:......| .|..|  |.|:.|:||||||..|.. .:.||:|:...|          .
Worm    12 SSDLHTSIRNSSSTK-HVFACVLGSGVAGSSVAYHLTKRNI-KDVLLLERASDGDFGVHGVASPS 74

  Fly   107 ELPWTACGLAGRFEPSYTELKLAEYSIDLIKRL-AENGLPTGWRPVGSLNLARSWDRMTAFNR-M 169
            ...:.:.||.....|::....:..:||:|..:| ||.|:...::|.|::.||.:..|:..|.: :
Worm    75 GTSFHSPGLVSASHPAHRYKPILAHSIELYSKLEAETGVNIDFQPTGTIRLATNETRLAEFRKYV 139

  Fly   170 KSQALAWGMHCE--ILSPEQCAQHCELLSLDGIEGGLWIPEDGVCDPQLVCQAYMIEAQRLGVRI 232
            .......|..|:  :|:|:|..:....:....|.|.|....||....:.:.||.::.|:..|.::
Worm   140 NRDYYKEGDVCKTTLLTPDQVRELAPDVDHSKILGALHTTNDGTISARALTQALVVGAKNGGAQV 204

  Fly   233 VEHCAIKKIHSE----HGKVRSVETTAGDVECEYFVNCTGFWAREVGTLSKPVVKVPLKAVEHHY 293
            ::....|:|..:    |..:...:.|.  |.....:|..|.||.::..||...  :|:..|||.|
Worm   205 IDGAIPKEIKYDKEKGHWIIALEDGTL--VTTRNLINAGGIWANDIARLSGHA--LPVVVVEHQY 265

  Fly   294 LHTKPIEGLSPDTPFVRDFDGRIFFRECEGHILAGGFEREAKMV-----YEDGVIPLSQTARQHP 353
            ....|.:...| ||.:.|.|...:.|:.....|.||||...|.|     |:.|| | ::.::...
Worm   266 AVLTPNKTPGP-TPAIIDHDSTFYVRKSGDDYLFGGFESLEKTVIREDWYKKGV-P-TEGSKSIQ 327

  Fly   354 PDWDHFHELLDALLLRVPSFRDATLDRLTNSLQVFS--PDCKWILGEAPEIQNYYVAAGNKTMGV 416
            .|:....:........:|..:.:.:|.   ...|||  ||...::|  |..:||:::.|... ||
Worm   328 ADFSRLDDAYKRACDLIPGLQGSKVDA---RAAVFSMTPDGYPLVG--PYDKNYWMSTGFLD-GV 386

  Fly   417 SASGGIGRVLTDLITKGSTYLDLHILDISRFLGLHNNRKFLRDRCKEAPGKHFEINYPFEEFQTG 481
            |:.||||:.|.|.|..|....:|...|.||: ....:|||..:|.:|....::  |:.:.:...|
Worm   387 SSGGGIGKYLADWIVDGEPPAELFDTDASRY-ERWGDRKFFTERSRETYSMYY--NWSYTDRSAG 448

  Fly   482 RNL-RMSPIYPQLKEAGAVFGQSMGYERPNYFDQQDKHDEFGLPRFRIAQTRTFGKPPWFDHVAS 545
            |.. |:|.:|.:||:.||.|....|:|..|.|:...:::|: ||.                 :..
Worm   449 RPTDRISGVYGRLKKDGASFSFRNGWEVANSFNMGVQNEEY-LPT-----------------LIR 495

  Fly   546 EYRACRERIGIADYSSFTKYDFWSKGNEVVDLLQYLCSNDVDVAVGSII-------HTGMQNPNG 603
            ||.....:.|:.|.|...|.:.  |||:...|:.|..::.:. |:|.|.       |.|:..|..
Worm   496 EYEMVTNKCGVIDLSWKGKIEV--KGNDAEKLMDYAIASQIP-ALGKISSGLMLTRHGGILGPMM 557

  Fly   604 GYENDCSLARLSERHYMMIAPTIQQTRSMCWIRKHMPNHLRAKVNVADVTSMYTAICILGPYSRI 668
            .:.:|     .....::::....:::|.:.|:|:..... :..|.|:.|:....::.::||.||.
Worm   558 IFHHD-----RQRSAFILLTEPERESRDLYWLRRAAAEK-KFDVQVSIVSEYLASLALVGPKSRE 616

  Fly   669 LLSELTDTDLTPKSFPFFTYKELDVGLADGIRVLNITHTGELGYVLYIPNEYALHVYSRLYQAGQ 733
            :||.||.:|::.:.||..:.:.:.:|....:...:.|.||:|.|.|:........:|:.:..||:
Worm   617 VLSALTKSDVSDEGFPQKSTRMIRLGPVGVVCARSSTSTGQLSYELFHNRAETAKLYNAVMSAGR 681

  Fly   734 KFNIQHAGYYATRALRIEKFYAFWGQDLDTFTTPLECGRSWRVKFNKPIDFIGRNALLKQREEGV 798
            :..|.:.|..|...:|:|..|..||::|...|.|.|||....|.|.|. :||||.:.|:.:::..
Worm   682 EHGIVNFGQAALNMMRLEHGYKIWGKELTLDTNPFECGIGGLVDFEKK-EFIGRESALELKKKDF 745

  Fly   799 KRMYVQLLLNDHDHEV-----DMWCWGGEPIYR-DG--VYVGMTTTTGYGYTFEKQVCLGFVRNF 855
            .....:|.|...|.|.     |.:...|..:.| ||  ..||..|:..|....:|.:...::.|.
Worm   746 DDSSRRLALITFDTEEGCVLDDRYVPSGNEVIRIDGKEARVGQITSGAYNVRLQKPIAFAWIDNA 810

  Fly   856 DDEGRELPVTNEYVLSGHYEVEVAGVRFEAKVNLHSPNLP 895
            ..:...|            .|::...|..| .:|.:|.:|
Worm   811 VGKNERL------------VVDIGDKRLFA-TSLETPTIP 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3626	NP_572162.2	DAO	70..429	CDD:279590	101/385 (26%)
		FAO_M	432..487	CDD:292961	14/55 (25%)
		GcvT	480..908	CDD:223481	106/432 (25%)
		GCV_T	490..774	CDD:279857	72/290 (25%)
		GCV_T_C	783..887	CDD:285832	24/111 (22%)
Y37E3.17	NP_001360456.1	DadA	26..421	CDD:223737	109/410 (27%)
Y37E3.17	NP_001360456.1	GcvT	447..838	CDD:223481	106/432 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D96522at33208
OrthoFinder	1	1.000	-	-		FOG0002575
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920