DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3626 and Sardh

DIOPT Version :9

Sequence 1:	NP_572162.2	Gene:	CG3626 / 31377	FlyBaseID:	FBgn0029706	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_446116.1	Gene:	Sardh / 114123	RGDID:	621125	Length:	919	Species:	Rattus norvegicus

Alignment Length:	965	Identity:	290/965 - (30%)
Similarity:	461/965 - (47%)	Gaps:	120/965 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LQRSGNAVSVVPRRRWC-SPGLSNAVRLSSSQMDPADERVLRKRKFQPQQAADLSEELAG----- 63
            |.|.....:..||.|.. :.||....|    :..|..|      |..|.|.. |.||..|
  Rat     4 LSRVLRVAATCPRGRSARNLGLQPLAR----EARPTTE------KSVPYQCT-LKEEAQGASVVP 57

  Fly    64 -----QLPVKSRVVICGGGITGASVAYHLGLRGWGGETLLVEQDRVGGELPWTACGLAGRFEPSY 123
                 .||..:.||:.|||..|....|||...|.|| .:|:|::|:.....|...||..:..||.
  Rat    58 QGPSQPLPSTANVVVIGGGSLGCQTLYHLAKLGVGG-VVLLERERLTSGTTWHTAGLLWQLRPSD 121

  Fly   124 TELKLAEYSIDLIKR--LAENGLPTGWRPVGSLNLARSWDRMTAFNRMKSQALAWGMHCEILSPE 186
            .|::|..::..::..  ..|.||.|||...|.|.:|.:..|:..:.|:.|...|:|:...:|||.
  Rat   122 VEVELLAHTRQVVSHDLEEETGLHTGWIQNGGLFIASNQQRLDEYKRLMSLGKAYGIESHVLSPA 186

  Fly   187 QCAQHCELLSLDGIEGGLWIPEDGVCDPQLVCQAYMIEAQRLGVRIVEHCAIKKIH---SEHG-- 246
            :......|:::|.:.|.|::|.||..||...|......|...|.:::|:||:..|.   .:.|
  Rat   187 ETKDLYPLMNVDDLYGTLYVPRDGTMDPAGTCTTLTRAAVARGAQVIENCAVTGIRVRTDDFGVR 251

  Fly   247 KVRSVETTAGDVECEYFVNCTGFWAREVGTLSKPVVKVPLKAVEHHYLHTKPIEGLSPDTPFVRD 311
            :|.:|||..|.::....|||.|.||..||.::.  |||||.|:.|.|:.|:.|||:. :.|.|||
  Rat   252 RVTAVETQHGSIQTPCVVNCAGVWASSVGRMAG--VKVPLVAMHHAYVVTERIEGIQ-NMPNVRD 313

  Fly   312 FDGRIFFRECEGHILA-GGFEREAKMVYED--------GVIPLSQTARQHPPDWDHFHELLDALL 367
            .|..::.| .:|..|: ||:  ||..::.|        |:..|         |||.|.:.::..:
  Rat   314 HDASVYLR-LQGDALSVGGY--EANPIFWDEVSDKFAFGLFDL---------DWDVFTQHIEGAI 366

  Fly   368 LRVPSFRDATLDRLTNSLQVFSPDCKWILGEAPEIQNYYVAAGNKTMGVSASGGIGRVLTDLITK 432
            .|||......:.......:.|:||.|.::|||||::.:::..|..:.|:...||.|:.|...|..
  Rat   367 NRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIVH 431

  Fly   433 GSTYLDLHILDISRF-LGLHNNRKFLRDRCKEAPGKHFEINYPFEEFQTGRNLRMSPIYPQLKEA 496
            |....|::..||.|| ..|.::.:::|:|..|:..|::.:.:|.:|...|||:|..|::.:|...
  Rat   432 GRPEKDMYSYDIRRFHHSLTDHPRWIRERSHESYAKNYSVVFPHDEPLAGRNMRRDPLHEELLGQ 496

  Fly   497 GAVFGQSMGYERPNYFDQQD----------------KHDEFGLPRFRIAQTRTFGKPPWFDHVAS 545
            |.||.:..|:|||.:|:.|:                .|.::...|. :....||..||....:..
  Rat   497 GCVFQERQGWERPGWFNPQETAQVLDYDYYGAYGHQAHKDYAYSRL-LGDEYTFDFPPHHCVIQK 560

  Fly   546 EYRACRERIGIADYSSFTKYDFWSKGNEVVDLLQYLCSNDVDVAVGSIIHTGMQNPNGGYENDCS 610
            |..|||....:.:.|.|.|  |:..|.:......:|.|.||:...||.::|.|.|..||.|:|.:
  Rat   561 ECLACRTAAAVFNMSYFGK--FYLLGADARKAPDWLFSADVNRPPGSTVYTCMLNQRGGTESDLT 623

  Fly   611 LARLS--------------ERHYMMIAPTIQQTRSMCWIRKHMPNHLRA-------KVNVADVTS 654
            ::.|:              :.:|:.:...:.|         |..:|:..       :..:.|.:.
  Rat   624 VSCLAPGAQASPLAPAFEGDGYYLAVGGAVAQ---------HNWSHINTVLQDQEFRCQLMDCSE 679

  Fly   655 MYTAICILGPYSRILLSELTDTDLTPKSFPFFTYKELDVGLADGIRVLNITHTGELGYVLYIPNE 719
            ....:.|.||.||.:|.::.|.||:.::|||.|: :|.......:|.:.::..||||:.|::|..
  Rat   680 DLGMLSIQGPASRDILQDVLDADLSNEAFPFSTH-QLVRAAGHLVRAIRLSFVGELGWELHVPQA 743

  Fly   720 YALHVYSRLYQAGQKFNIQHAGYYATRALRIEKFYAFWGQDLDTFTTPLECGRSWRVKFNKPIDF 784
            ..|.||..:..||.|..:.:|||.|..:|.|||.|..|..||.:..:|||.|.::..|....:.|
  Rat   744 SCLPVYRAVMAAGAKHGLVNAGYRAIDSLSIEKGYRHWHADLRSDDSPLEAGLAFTCKLKTSVPF 808

  Fly   785 IGRNALLKQREEGVKRMYVQLLLNDHDHEVDMWCWGGEPIYRDGVYVGMTTTTGYGYTFEKQVCL 849
            :||.||.|||..|::|..|.|.:   :.||.|  :|.|.|:|:|..||......:|:|..|.:..
  Rat   809 LGREALEKQRATGLRRRLVCLTV---EEEVPM--FGLEAIWRNGQVVGHVRRADFGFTVNKTIAY 868

  Fly   850 GFVRNFDDEGRELPVTNEYVLSGHYEVEVAGVRFEAKVNLHSPNLPTKF-PDRER 903
            |::|  |..|.  ||:.::|.:|.|.:|..||.:.|:|:|.||     | ||.:|
  Rat   869 GYIR--DPSGG--PVSLDFVKNGDYALERMGVTYAAQVHLKSP-----FDPDNKR 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3626	NP_572162.2	DAO	70..429	CDD:279590	118/374 (32%)
		FAO_M	432..487	CDD:292961	17/55 (31%)
		GcvT	480..908	CDD:223481	139/462 (30%)
		GCV_T	490..774	CDD:279857	87/320 (27%)
		GCV_T_C	783..887	CDD:285832	38/103 (37%)
Sardh	NP_446116.1	DadA	64..448	CDD:223737	127/399 (32%)
		FAO_M	431..486	CDD:292961	16/54 (30%)
		GcvT	480..917	CDD:223481	139/462 (30%)
		GCV_T	490..799	CDD:279857	87/321 (27%)
		GCV_T_C	808..>872	CDD:285832	26/68 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D96522at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820