DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3626 and pdpr

DIOPT Version :9

Sequence 1:	NP_572162.2	Gene:	CG3626 / 31377	FlyBaseID:	FBgn0029706	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	XP_002931709.2	Gene:	pdpr / 100492638	XenbaseID:	XB-GENE-5791461	Length:	865	Species:	Xenopus tropicalis

Alignment Length:	828	Identity:	369/828 - (44%)
Similarity:	525/828 - (63%)	Gaps:	18/828 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LPVKSRVVICGGGITGASVAYHLGLRGWGGETLLVEQDRVGGELPWTACGLAGRFEPSYTELKLA 129
            ||.:::||||||||.||||||||...|| .:.||:||.|:.........|:....:....|.::|
Frog    35 LPPRAQVVICGGGIMGASVAYHLSKLGW-HDVLLLEQGRLAAGSTRFCAGMVSTIKHISIETEMA 98

  Fly   130 EYSIDLIKRL-AENGLPTGWRPVGSLNLARSWDRMTAFNRMKSQALAWGMHCEILSPEQCAQHCE 193
            :||..|.::| .|.|:.||::.:||:.||::.||:.:..|:.|:....|:.|||::|:..|:...
Frog    99 DYSNKLYQQLEGETGVATGYKKMGSITLAQTQDRLISLKRIVSRLRMKGIPCEIITPKHVAELHP 163

  Fly   194 LLSLDGIEGGLWIPEDGVCDPQLVCQAYMIEAQRLGVRIVEHCAIKKIHSEHGKVRSVETTAGDV 258
            |:::..:.|.:::|:|.|.....|..|.:..||:.||::.||..:..:..|.|.|..|:|..|.|
Frog   164 LINIHDLVGAMYVPDDAVVSTADVTLALVNAAQQKGVKVHEHTTVNHVLVEKGHVSGVDTDRGQV 228

  Fly   259 ECEYFVNCTGFWAREVGTLSKPVVKVPLKAVEHHYLHTKPIE-GLSPDTPFVRDFDGRIFFRECE 322
            ||||||||.|.||.|:|..::..|.:||.|.||.||.|:|:: .|..:.|.|.|.||||:.|..:
Frog   229 ECEYFVNCAGQWAYELGLSNESPVSIPLHACEHFYLLTQPLQHPLEDNVPTVVDPDGRIYIRNWQ 293

  Fly   323 GHILAGGFEREAKMVYEDGVIPLSQTARQHPPDWDHFHELLDALLLRVPSFRDATLDRLTNSLQV 387
            |.||:||||:..|.::.:|...|.....|.  |||||..||.|||.|:||.....:.||.|..:.
Frog   294 GGILSGGFEKNPKPIFTEGRNQLEIQNLQE--DWDHFEPLLTALLRRMPSLEALEILRLVNCPEA 356

  Fly   388 FSPDCKWILGEAPEIQNYYVAAGNKTMGVSASGGIGRVLTDLITKGSTYLDLHILDISRFLGLHN 452
            |:||.:.::||:|.:.:|:..||..:.|.|..||.|:.|.:.:..|....::..|||.||..|.:
Frog   357 FTPDMRCVMGESPTLLHYFTLAGMNSQGCSLGGGAGKFLAEWMVFGYPQDNVWPLDIKRFGALQS 421

  Fly   453 NRKFLRDRCKEAPGKHFEINYPFEEFQTGRNLRMSPIYPQLKEAGAVFGQSMGYERPNYFDQQDK 517
            :|.|||.|..|.....:::..|..:|||||.||.||:|.:|...||.:.:..|:||..||....|
Frog   422 SRTFLRHRVMEVMPLIYDLKVPRWDFQTGRQLRTSPLYDRLDAQGARWMEKHGFERAKYFVPPGK 486

  Fly   518 HDEFGLPRFRIAQTRTFGKPPWFDHVASEYRACRERIGIADYSSFTKYDFWSKGNEVVDLLQYLC 582
             |...|.     |::||.||.|||.|.||.:.|:|.:.:.|.|||||::..|.|.:.:|.||||.
Frog   487 -DLLALD-----QSKTFYKPDWFDIVGSEVKCCKEAVCVIDMSSFTKFEISSPGEQALDTLQYLF 545

  Fly   583 SNDVDVAVGSIIHTGMQNPNGGYENDCSLARLSERHYMMIAPTIQQTRSMCWIRKHMPNHLRAKV 647
            |||:||.||.|:||||.|..||||||||:.||::|.:.||:||.||.....|:|:|||:.  :.:
Frog   546 SNDLDVPVGHIVHTGMLNERGGYENDCSIVRLNKRSFFMISPTDQQVHCWSWLRQHMPSD--SDL 608

  Fly   648 NVADVTSMYTAICILGPYSRILLSELTDTDLTPKSFPFFTYKELDVGLADGIRVLNITHTGELGY 712
            .:.|||..|||:.::||.:..:||||:...:|.:.||....||:.||.|:||||:::|||||.|:
Frog   609 FLEDVTWKYTALNLIGPRAVDVLSELSYAPMTSEHFPSLFCKEMSVGYANGIRVMSMTHTGEPGF 673

  Fly   713 VLYIPNEYALHVYSRLYQAGQKFNIQHAGYYATRALRIEKFYAFWGQDLDTFTTPLECGRSWRVK 777
            .||||.|||||||:.|...|||:.|::|||||.|:||||||:||||||||.|||||||||.:|||
Frog   674 TLYIPIEYALHVYNELMSVGQKYGIRNAGYYALRSLRIEKFFAFWGQDLDAFTTPLECGREFRVK 738

  Fly   778 FNKPIDFIGRNALLKQREEGVKRMYVQLLLNDHDHEVDMWCWGGEPIYRDGVYVGMTTTTGYGYT 842
            .:|..|||||.|||||||||:.:.:...:|.|||.::|:|.|.||||||:|.:||.||::.|.||
Frog   739 LDKGYDFIGREALLKQREEGIFKRFTMFILEDHDTDLDLWPWWGEPIYRNGEHVGKTTSSAYSYT 803

  Fly   843 FEKQVCLGFVRNFDDEGRELPVTNEYVLSGHYEVEVAGVRFEAKVNLH 890
            ..:.|||||:.:     .:.|:|.|::..|.|.:::|..:|:||..|:
Frog   804 LGRHVCLGFIHS-----NQQPITPEFINRGEYHIDIASQKFKAKAKLY 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3626	NP_572162.2	DAO	70..429	CDD:279590	142/360 (39%)
		FAO_M	432..487	CDD:292961	21/54 (39%)
		GcvT	480..908	CDD:223481	209/411 (51%)
		GCV_T	490..774	CDD:279857	148/283 (52%)
		GCV_T_C	783..887	CDD:285832	48/103 (47%)
pdpr	XP_002931709.2	DadA	35..422	CDD:223737	151/389 (39%)
pdpr	XP_002931709.2	GcvT	449..813	CDD:223481	198/371 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	295	1.000	Domainoid score	I1467
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H9948
Inparanoid	1	1.050	712	1.000	Inparanoid score	I634
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D137947at2759
OrthoFinder	1	1.000	-	-		FOG0002575
OrthoInspector	1	1.000	-	-		oto103689
Panther	1	1.100	-	-	LDO	PTHR13847
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5511
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160