DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment norpA and PLCD4

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	XP_011510314.1	Gene:	PLCD4 / 84812	HGNCID:	9062	Length:	820	Species:	Homo sapiens

Alignment Length:	878	Identity:	265/878 - (30%)
Similarity:	411/878 - (46%)	Gaps:	180/878 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIRAGGTPKDPKIL----DKVTKK 91
            ::.:...:::...|::...|..: |.:....|.......:||:.......|.::|    :::..:
Human    25 RKVRSKSWKKLRYFRLQNDGMTV-WHARQARGSAKPSFSISDVETIRNGHDSELLRSLAEELPLE 88

  Fly    92 NGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKIWLDGIRKITHNVKANNICPMMCLRKH 156
            .|..|....:|     ||.|        ::......|:||:.|::.:...|.:.:         |
Human    89 QGFTIVFHGRR-----SNLD--------LMANSVEEAQIWMRGLQLLVDLVTSMD---------H 131

  Fly   157 WMRLSYCV---------EKSGKI---PVKTLAKTFASGKTEKLVYTCIKDAGLPDDKNATMTKEQ 209
            ..||...:         .:.||:   .|:.|.........::..::..:.|    |.:.:.|.|.
Human   132 QERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAA----DTSQSGTLEG 192

  Fly   210 FTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPLYEEKRC 274
            ..|.:||....|   |.:::|||.|.:...|. ::|.:|:.|:.::|:             |:.|
Human   193 EEFVQFYKALTK---RAEVQELFESFSADGQK-LTLLEFLDFLQEEQK-------------ERDC 240

  Fly   275 T-----EIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDR-LDFYMEMDQPLAHYYINSS 333
            |     |:|:.||..:..|....:|:|||..||.| ::..:|... |..|.:|.|||.||:|.||
Human   241 TSELALELIDRYEPSDSGKLRHVLSMDGFLSYLCS-KDGDIFNPACLPIYQDMTQPLNHYFICSS 304

  Fly   334 HNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAI 398
            |||||.|.|:.|:||||.|.:.|..||||||:|.|:  |...||:|.|||...:.|||||.:..:
Human   305 HNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWD--GPSGEPVVYHGHTLTSRILFKDVVATV 367

  Fly   399 ADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLP--LPPPCKLK 461
            |..||.:|:||||||.|.||:..||..:|::..:..|:.||..     .||..||  ||.|.:|:
Human   368 AQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLST-----TLDGVLPTQLPSPEELR 427

  Fly   462 RKILIKNKRM-------------KPEVEKVELELWLKGELKTDDDPEEDASAGKPPE-------- 505
            ||||:|.|::             :||:|  |.||.|:.:.:|:.:|:|.....|..:
Human   428 RKILVKGKKLTLEEDLEYEEEEAEPELE--ESELALESQFETEPEPQEQNLQNKDKKKVVTCPLF 490

  Fly   506 --------AAAAPAPAPEAAAAAEGAAEGGGGAEAEAAAANYSGSTTNVHPWLSSMVNYAQPIKF 562
                    .|.||...||:...:.                  ..|...:.|.|||:|.|.:.:.|
Human   491 CPSICCQIVAQAPISKPESLLLSR------------------QKSKPILCPALSSLVIYLKSVSF 537

  Fly   563 QGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNA 627
            :.|..:.|....:.:|||:|:.....:|::..:||.:|..|:||:||.|.|.|||||.||..|||
Human   538 RSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNA 602

  Fly   628 GCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKV 692
            |||||::|.|::.|.|.:..|.|..||||||:|||||:|.....|.|  :.|:....|....::|
Human   603 GCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHP--EKPISPFKAQTLLIQV 665

  Fly   693 IAGQFLS--DK-KVGTYVE----VDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRKVVLP 750
            |:||.|.  || |.|:.|:    |.:||:..||.::|  |..|.|||.||.:.: ...|| |::|
Human   666 ISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQE--TNYVENNGFNPYWGQ-TLCFR-VLVP 726

  Fly   751 DLAVLRF----------------------------------GVYEESGKILGQRILPLDGLQAGY 781
            :||:|||                                  |.|..||.:....:|||    .||
Human   727 ELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGEPAPLAPGQYPSSGCLPNAVLLPL----PGY 787

  Fly   782 RHVSLRTEANFPMSLPMLFVNIELKIYVPDGFE 814
            ||:.|.::....:....:||    .|.:.:|.|
Human   788 RHIHLLSKDGISLRPASIFV----YICIQEGLE 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	19/121 (16%)
		PLN02952	224..786	CDD:178538	225/639 (35%)
		EF-hand_like	227..318	CDD:286375	26/96 (27%)
		PI-PLCc_beta	318..653	CDD:176533	139/365 (38%)
		C2_PLC_like	689..806	CDD:175974	46/157 (29%)
		DUF1154	866..908	CDD:284131
		Mer2	<887..1003	CDD:286200
PLCD4	XP_011510314.1	PH	17..123	CDD:278594	18/111 (16%)
		PH_PLC_delta	18..133	CDD:270169	20/130 (15%)
		EF-hand_7	143..199	CDD:290234	9/59 (15%)
		EF-hand_10	153..202	CDD:291454	10/52 (19%)
		PLN02222	207..765	CDD:177868	213/605 (35%)
		EF-hand_like	207..289	CDD:286375	26/96 (27%)
		PI-PLCc_GDPD_SF	289..628	CDD:301322	139/365 (38%)
		C2_PLC_like	658..809	CDD:175974	47/162 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820