DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment norpA and Plcl1

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	NP_445908.2	Gene:	Plcl1 / 84587	RGDID:	708420	Length:	1096	Species:	Rattus norvegicus

Alignment Length:	1124	Identity:	279/1124 - (24%)
Similarity:	452/1124 - (40%)	Gaps:	270/1124 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGD--VIELCQVSDIRAG--- 76
            :..||..       |:.:.|....:..|.:|.....|.|:...:|.:  .:::..:.:||.|
  Rat   116 MQAGCEL-------KKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNT 173

  Fly    77 GTPKDPKILDKVTKK------NGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKIWLDGI 135
            .|.::..:.|::.:.      :|.|...||                   ::...|..|.||:.|:
  Rat   174 ETFRNNGLADQICEDCAFSILHGENYESLD-------------------LVANSADVANIWVSGL 219

  Fly   136 RKITHNVK-------ANNICPMMCLRKHWMRLSY----------CVEKSGKIPVKTLAKTFASGK 183
            |.:....|       .|...|    |..|::..:          .:|.:....:|.|..|....|
  Rat   220 RYLVSRSKQPLDFMEGNQNTP----RFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKESK 280

  Fly   184 TEKLVYTCIKDAGLPDDKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQF 248
            ..      :|...:...|....|:  .|.::|...:.::|.|.::..|...|:|.| :::.....
  Rat   281 IR------LKFKEIQKSKEKLTTR--VTEEEFCEAFCELCTRPEVYFLLVQISKNK-EYLDANDL 336

  Fly   249 IQFMNDKQRDPRMNEILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLD 313
            :.|:..:|....:.|.:        |.:||..|||.|:.::...:::|||.:||:|.|......:
  Rat   337 MLFLEVEQGVTHVTEDM--------CLDIIRRYELSEDGRQKGFLAIDGFTQYLLSPECDIFDPE 393

  Fly   314 RLDFYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPI 378
            :.....:|.|||:|||||:||||||...|..|.:.:..|.:.|..|||.:|||.  ..|.|.|||
  Rat   394 QKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYVRALKMGCRSIELDV--SDGPDNEPI 456

  Fly   379 VTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPL 443
            :.:.:.....:.|:..::.|...|||:||||:||...|||:..||..:.:.....||:.|..|.
  Rat   457 LCNRNNMAMLLSFRSVLEVINKFAFVASEYPLILCLGNHCSLPQQRVMVQQMKKVFGNKLYTEA- 520

  Fly   444 PDHPLDPGLPLPPPCKLKRKILIKNKRMKPEVEKVELELWLKGELKTDDDPEEDASAGKPPEAAA 508
               ||.....||.|.|||..|::|.|::..|.:.:|      ||: ||:|.|.:.|
  Rat   521 ---PLSSESYLPSPEKLKHMIIVKGKKLPSESDLLE------GEV-TDEDEEAEMS--------- 566

  Fly   509 APAPAPEAAAAAEGAAEGGGGAEAEAAAANYSGSTTNVHPW----LSSMVNYAQPIKFQGFDKAI 569
                                    ...:.:|:|.  ..|.|    ||.:|:..:.::::.|:.::
  Rat   567 ------------------------RRVSGDYNGE--QKHIWLCRELSDLVSICKSVQYRDFELSM 605

  Fly   570 EKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSL 634
            :......:.||:|:.......:...|||||||:.:||:||...|.||||..||.|||.|||:|::
  Rat   606 KTQNYWEICSFSETLASRIANEYPEDFVNYNKKFLSRVYPSAMRIDSSNLNPQDFWNCGCQIVAM 670

  Fly   635 NFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQFLS 699
            |||:....|.|:.|.|..||||||:|:|..||.....|.......|.||......:|:|:||...
  Rat   671 NFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGIVPGVSPLLLHIKIISGQNFP 735

  Fly   700 DKK--------VGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRKVVLPDLAVLR 756
            ..|        :..||.|::.|:|:|.  .|.||:.|..|..||:::| .|.| :|.||:|.::|
  Rat   736 KPKGACAKGDVIDPYVCVEIHGIPADC--SEQRTKTVQQNSDNPIFDE-TFEF-QVNLPELTMVR 796

  Fly   757 FGVYEE---SGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIELKIYVPDGFEDFMA 818
            |.:.::   ..:.:||..:|.:.||.|||||.||:.....|....|||:|
  Rat   797 FVILDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHI--------------- 846

  Fly   819 MLSDPRGFAGAAKQQNEQMKALGIEEQSGGAARDAGKAKEEEKKEPPLVFEPVTLESLRQEKGFQ 883
                                  .|..:|||
  Rat   847 ----------------------AITNRSGG----------------------------------- 854

  Fly   884 KVGKKQIKELDTLRKKHAKERTSVQKTQNAAIDKLIKGKSKDDIRNDANIKNSINDQTKQWTDMI 948
              ||.|.:.|.....|..:|.|.::......||.:.|                           |
  Rat   855 --GKAQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFK---------------------------I 890

  Fly   949 ARHRKEEWDMLRQHVQDSQDAMKALMLTVQAAQIKQ----LEDR-------------------HA 990
            |.|...|...:|:::|::..::|.|......|.:||    |..|                   :.
  Rat   891 AVHPLREAIDMRENMQNAIVSVKELCGLPPIASLKQCLLTLSSRLITSDSTPSVSLVMKDCFPYL 955

  Fly   991 RDIKDLNAKQAKMSADTAKEVQNDKTLKTKNEKDRRLREKRQNNVKRFMEEKKQIGVKQGRAMEK 1055
            ..:..:...|.:|.|.....:|..:.|....:..:....:.|.....|.||...:|.|:|....|
  Rat   956 EPLGTIPDVQKRMLAAYDLMIQESRVLIEMADTVQEKIVQCQKAGMEFHEELHNLGAKEGLKGRK 1020

  Fly  1056 LKLAHSKQIEEFSTDVQKL 1074
            |    :|.||.|:.::..|
  Rat  1021 L----NKAIESFAWNITVL 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	26/149 (17%)
		PLN02952	224..786	CDD:178538	186/576 (32%)
		EF-hand_like	227..318	CDD:286375	21/90 (23%)
		PI-PLCc_beta	318..653	CDD:176533	113/338 (33%)
		C2_PLC_like	689..806	CDD:175974	44/127 (35%)
		DUF1154	866..908	CDD:284131	7/41 (17%)
		Mer2	<887..1003	CDD:286200	23/138 (17%)
Plcl1	NP_445908.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..101
		Interaction with PPP1C	83..222		24/131 (18%)
		PH_PLC_eta	116..224	CDD:270170	24/133 (18%)
		EFh_PI-PLC	244..386	CDD:333715	33/158 (21%)
		EF-hand motif	244..273	CDD:320029	3/28 (11%)
		EF-hand motif	280..312	CDD:320029	6/39 (15%)
		EF-hand motif	316..344	CDD:320029	5/28 (18%)
		EF-hand motif	353..386	CDD:320029	13/40 (33%)
		PI-PLCc_PRIP_metazoa	399..689	CDD:176539	113/337 (34%)
		Interaction with GABA A beta subunit	544..568		9/63 (14%)
		C2_PLC_like	721..849	CDD:175974	44/168 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1067..1096
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920