DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment norpA and PLC5

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	NP_001332556.1	Gene:	PLC5 / 835983	AraportID:	AT5G58690	Length:	578	Species:	Arabidopsis thaliana

Alignment Length:	602	Identity:	172/602 - (28%)
Similarity:	260/602 - (43%)	Gaps:	107/602 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 PRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPLYEEKRCTEIINDYELDEEKK 288
            |..|:...|...|:|: ..::.||..:|:.:.|.:   .|:|  :.:.::..|.|........|.
plant    25 PPQDVVTAFVEYTEGR-SHMTAEQLCRFLVEVQDE---TEVL--VSDAEKIIERITCERHHITKF 83

  Fly   289 KNVQMSLDGFKRYLMSDE-NAPVFLDRLDFYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMY 352
            ....::||.|..:|.||: |.|:   ....:.:|..||:||:|.:|||:||:|.||..:.|....
plant    84 LRHTLNLDDFFSFLFSDDLNHPI---DSKVHQDMASPLSHYFIYTSHNSYLTGNQINSECSDVPL 145

  Fly   353 RQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENH 417
            .:.|..|.|.:|||.|....:| :.:|.||.|:...:....|:::|.:.||.:|.|||||:.|:|
plant   146 IKALKRGVRALELDMWPNSTKD-DILVLHGWAWTPPVELVKCLRSIKEHAFYASAYPVILTLEDH 209

  Fly   418 CNRAQQYKLAKYCDDFFGDLL-------LKEPLPDHPLDPGLPLPPPCKLKRKILIKNKRMKPEV 475
            .....|.|.|:...:.|.|::       |||            .|.|..||.||:|..   ||.
plant   210 LTPDLQAKAAEMMKEIFMDMVYFPEAGGLKE------------FPSPEDLKYKIVIST---KPP- 258

  Fly   476 EKVELELWLKGELKTDDDPEEDASAGKPPEAAAAPAPAPEAAAAAEGAAEGGGGAEAEAAAANYS 540
                     ||.|:.|.|.|.|||.....:.:|......|..:.|:...:|.....:......||
plant   259 ---------KGSLRKDKDSESDASGKASSDVSADDEKTEEETSEAKNEEDGFDQESSNLDFLTYS 314

  Fly   541 GSTT----NVHPWLSSMVNYAQ------PIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSID 595
            ...|    |....|...:....      .::.|.|.||.|                    ....:
plant   315 RLITIPSGNAKNGLKEALTIDNGGVRRLSLREQKFKKATE--------------------MYGTE 359

  Fly   596 FVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLL 660
            .:.:.::.:.|||||.||.:||||.|...|..|.|||:.|.|.....:.:..|.|..||||||:.
plant   360 VIKFTQKNLLRIYPKATRVNSSNYRPYNGWMYGAQMVAFNMQGYGRALWMMHGMFRGNGGCGYVK 424

  Fly   661 KPDFMRR---ADKDFDPFADAPVDGVIAAQCSVKVIAGQ----------FLSDKKVGTYVEVDMF 712
            |||||..   :.:.|:|.|..|:...:    .|||..|:          |.:......|..|.:.
plant   425 KPDFMMNNNLSGEVFNPKAKLPIKKTL----KVKVYMGKGWDSGFQRTCFNTWSSPNFYTRVGIT 485

  Fly   713 GLPSDTV----KKEFRTRLVANNGLNPVYNEDPFVFRKVVLPDLAVLRFGVYE----ESGKILGQ 769
            |:..|.|    |||.:|       ..|.:||: |.| ::.:|:||:||..|::    |.....||
plant   486 GVRGDKVMKKTKKEQKT-------WEPFWNEE-FEF-QLTVPELALLRIEVHDYNMPEKDDFSGQ 541

  Fly   770 RILPLDGLQAGYRHVSL 786
            ..||:..|:.|.|.|.|
plant   542 TCLPVSELRQGIRSVPL 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167
		PLN02952	224..786	CDD:178538	171/600 (29%)
		EF-hand_like	227..318	CDD:286375	21/91 (23%)
		PI-PLCc_beta	318..653	CDD:176533	100/351 (28%)
		C2_PLC_like	689..806	CDD:175974	35/116 (30%)
		DUF1154	866..908	CDD:284131
		Mer2	<887..1003	CDD:286200
PLC5	NP_001332556.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	112	1.000	Domainoid score	I2055
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	1	1.000	-	-		mtm1043
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10336
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.920