DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment norpA and PLC1

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	NP_568881.1	Gene:	PLC1 / 835981	AraportID:	AT5G58670	Length:	561	Species:	Arabidopsis thaliana

Alignment Length:	635	Identity:	172/635 - (27%)
Similarity:	274/635 - (43%)	Gaps:	144/635 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 KEQFTFDKFYALYHKVC-------------PRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRD 258
            ||.|          |||             |..:|:.||...:  :.|.:|.::.::|:...|.:
plant     2 KESF----------KVCFCCVRNFKVKSSEPPEEIKNLFHDYS--QDDRMSADEMLRFVIQVQGE 54

  Fly   259 PR-----MNEILYPLYEEKRCTEIINDYELDEEKKKNV----QMSLDGFKRYLMSDENAPVFLDR 314
            ..     :.:|.:.|                  |...|    .:.|:||.|||:||.|:|:.|.|
plant    55 THADINYVKDIFHRL------------------KHHGVFHPRGIHLEGFYRYLLSDFNSPLPLTR 101

  Fly   315 LDFYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCW-NGKGEDEEPI 378
             :.:.:|:|||:||::.:.||:||:|.|:...||:|...:.|..|.|.:|||.| |..|::.|
plant   102 -EVWQDMNQPLSHYFLYTGHNSYLTGNQLNSNSSIEPIVKALRNGVRVIELDLWPNSSGKEAE-- 163

  Fly   379 VTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPL 443
            |.||....:....:.|:..:.:.||..|.|||:|:.|:|.....|.|:||.....||..|.:  .
plant   164 VRHGGTLTSREDLQKCLNVVKENAFQVSAYPVVLTLEDHLTPILQKKVAKMVSKTFGGSLFQ--C 226

  Fly   444 PDHPLDPGLPLPPPCKLKRKILIKNKRMKPEVEKVELELWLKGELKTDDDPEEDASAGKPPEAAA 508
            .|...:   ..|.|..||.||||..|..|.         :|:.::......:|...|.|..:|..
plant   227 TDETTE---CFPSPESLKNKILISTKPPKE---------YLQTQISKGSTTDESTRAKKISDAEE 279

  Fly   509 APAPAPEAAAAAE---------GAAEGGGGAEAEAAAANYSGSTTNVHPWLSSMVNYAQPIKFQG 564
            ......|.:.|.|         |..:||                      |.:.:| ..|
plant   280 QVQEEDEESVAIEYRDLISIHAGNRKGG----------------------LKNCLN-GDP----- 316

  Fly   565 FDKAIEKNIAHN-MSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAG 628
             ::.|..:::.. :.:.|::.|.        |.|.:.:|.:.||:||.||.|||||.|.|.|..|
plant   317 -NRVIRLSMSEQWLETLAKTRGP--------DLVKFTQRNLLRIFPKTTRFDSSNYDPLVGWIHG 372

  Fly   629 CQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKD---FDPFA-DAPVDGVIAAQCS 689
            .|||:.|.||....:.:.||.|:.||||||:.|||.:.....:   |||.: :.|:...:    .
plant   373 AQMVAFNMQSHGRYLWMMQGMFKANGGCGYVKKPDVLLSNGPEGEIFDPCSQNLPIKTTL----K 433

  Fly   690 VKVIAGQ----------FLSDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVF 744
            ||:..|:          |........|.:|.:.|:|.||.  .:||.:..:... |::::: |.|
plant   434 VKIYTGEGWNMDFPLDHFDRYSPPDFYAKVGIAGVPLDTA--SYRTEIDKDEWF-PIWDKE-FEF 494

  Fly   745 RKVVLPDLAVLRFGV--YEES--GKILGQRILPLDGLQAGYRHVSLRTEA 790
             .:.:|:|::|...|  |:.:  ....||...||..::.|.|.|.|...|
plant   495 -PLRVPELSLLCITVKDYDSNTQNDFAGQTCFPLSEVRPGIRAVRLHDRA 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167
		PLN02952	224..786	CDD:178538	164/599 (27%)
		EF-hand_like	227..318	CDD:286375	23/99 (23%)
		PI-PLCc_beta	318..653	CDD:176533	100/345 (29%)
		C2_PLC_like	689..806	CDD:175974	29/116 (25%)
		DUF1154	866..908	CDD:284131
		Mer2	<887..1003	CDD:286200
PLC1	NP_568881.1	PLN02228	1..561	CDD:177873	172/635 (27%)
		EF-hand_like	25..102	CDD:286375	23/97 (24%)
		PI-PLCc_GDPD_SF	105..397	CDD:301322	100/344 (29%)
		C2_PLC_like	429..556	CDD:175974	29/124 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	112	1.000	Domainoid score	I2055
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	1	1.000	-	-		mtm1043
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10336
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.920