DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment norpA and PLC2

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	NP_001030660.1	Gene:	PLC2 / 819999	AraportID:	AT3G08510	Length:	581	Species:	Arabidopsis thaliana

Alignment Length:	615	Identity:	174/615 - (28%)
Similarity:	258/615 - (41%)	Gaps:	128/615 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 PRMNEILYPLYEEKRCTEI-------INDYELDEEKKKNVQ--------------MSLDGFKRYL 302
            ||..:.::..|.|.....:       |:..:.|:..:::.|              :.||.|.:||
plant    24 PREIKTIFEKYSENGVMTVDHLHRFLIDVQKQDKATREDAQSIINSASSLLHRNGLHLDAFFKYL 88

  Fly   303 MSDENAPVFLDRLDFYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDC 367
            ..|.|.|:.|.::  :.:||.|::||:|.:.||:||:|.|:....|.......|..|.|.:|||.
plant    89 FGDNNPPLALHKV--HHDMDAPISHYFIFTGHNSYLTGNQLSSDCSEVPIIDALKKGVRVIELDI 151

  Fly   368 WNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDD 432
            |....:|:..:: ||....|.:....|::||...||..|:|||:::.|:|.....|.|:|:...:
plant   152 WPNSNKDDIDVL-HGMTLTTPVGLIKCLKAIRAHAFDVSDYPVVVTLEDHLTPDLQSKVAEMVTE 215

  Fly   433 FFGDLLLKEPLPDHPLDPGLPLPPPCKLKRKILIKNKRMK-----PEVEKVEL-------ELW-- 483
            .||::|...|:.:...:    .|.|..|||:|:|..|..|     .:||.|:.       |:|
plant   216 IFGEILFTPPVGESLKE----FPSPNSLKRRIIISTKPPKEYKEGKDVEVVQKGKDLGDEEVWGR 276

  Fly   484 ----------------LKGELKTDDDPEEDASAGKPPEAAAAPAPAPEAAAAAEGAAEGGGGAEA 532
                            |.|....|||.:||.|....|       |..:...|.......||..|.
plant   277 EVPSFIQRNKSEAKDDLDGNDDDDDDDDEDKSKINAP-------PQYKHLIAIHAGKPKGGITEC 334

  Fly   533 EAAAANYSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFV 597
                       ..|.|                 ||....:::...   .|.|...|.||    .|
plant   335 -----------LKVDP-----------------DKVRRLSLSEEQ---LEKAAEKYAKQ----IV 364

  Fly   598 NYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKP 662
            .:.:..:.||||||||..||||.|.|.|:.|.|||:.|.|.....:.|.||.|..||||||:.||
plant   365 RFTQHNLLRIYPKGTRVTSSNYNPLVGWSHGAQMVAFNMQGYGRSLWLMQGMFRANGGCGYIKKP 429

  Fly   663 DFMRRADKD---FDPFADAPVDGVIAAQCSVKVIAGQ----------FLSDKKVGTYVEVDMFGL 714
            |.:.::..|   |||.|..||...:    .|.|..|:          |........|..|.:.|:
plant   430 DLLLKSGSDSDIFDPKATLPVKTTL----RVTVYMGEGWYFDFRHTHFDQYSPPDFYTRVGIAGV 490

  Fly   715 PSDTVKKEFRTRLVANNGLNPVYNEDPFVFR-KVVLPDLAVLRFGVYE----ESGKILGQRILPL 774
            |.|||.|  :|:.:.:|.: |.::|   ||. .:.:|:||:||..|:|    |.....||..||:
plant   491 PGDTVMK--KTKTLEDNWI-PAWDE---VFEFPLTVPELALLRLEVHEYDMSEKDDFGGQTCLPV 549

  Fly   775 DGLQAGYRHVSLRTEANFPMSLPMLFVNIE 804
            ..|..|.|...|.:..........|.|.:|
plant   550 WELSEGIRAFPLHSRKGEKYKSVKLLVKVE 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167
		PLN02952	224..786	CDD:178538	170/595 (29%)
		EF-hand_like	227..318	CDD:286375	16/79 (20%)
		PI-PLCc_beta	318..653	CDD:176533	105/364 (29%)
		C2_PLC_like	689..806	CDD:175974	37/131 (28%)
		DUF1154	866..908	CDD:284131
		Mer2	<887..1003	CDD:286200
PLC2	NP_001030660.1	PLN02222	1..581	CDD:177868	174/615 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	112	1.000	Domainoid score	I2055
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	1	1.000	-	-		mtm1043
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10336
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.920