Protein Alignment norpA and Plcd3

DIOPT Version :10

• Sequence 1: NP_525069.2
• Gene: norpA / 31376
• FlyBaseID: FBgn0262738
• Length: 1095
• Species: Drosophila melanogaster
• Sequence 2: NP_690026.2
• Gene: Plcd3 / 72469
• MGIID: 107451
• Length: 785
• Species: Mus musculus
• Alignment Length: 705
• Identity: 231/705 - (32%)
• Similarity: 354/705 - (50%)
• Gaps: 93/705 - (13%)

  Fly   123 PDAATAKSWQKNLRLITHNNRATNVCPRVNLMKHWMRLSYC----VEKSGKI---PVKTLAKTFA 180
            |.|..|:.|.:.|..:.....|.:...|::   ||:. ||.    .::..|:   .:|:|.:...
Mouse   151 PTAEEAQRWVRGLAKLRARLDAMSQRERLD---HWIH-SYLHRADSDQDSKMSFKEIKSLLRMVN 211

  Fly   181 SGKTEKLVYTCIKDAGLPDDKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISL 245
            ....:...|...|:.   |..|    .|:....:..|...::..|.::||:|...: |:...:|.
Mouse   212 VDMNDMYAYRLFKEC---DHSN----NERLEGAEIEAFLRRLLKRPELEEIFRRYS-GEDRVLSA 268

  Fly   246 EQFIQFMNDKQRDPRMNEILYPLYEEKRCT-EIINDYELDEEKKKNVQMSLDGFKRYLMSDENAP 309
            .:.::|:.|:..|.          ....|. ::|..|||:|..|::..|:||||..||:|.|.|.
Mouse   269 SELLEFLEDQGEDG----------ATLACAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAA 323

  Fly   310 VFLDRLDFYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGED 374
            :.:.....:.:|.||||||:|:|||||||:..||||.||.|.|.:....||||||||||.|.|
Mouse   324 LNVAHTCVFQDMGQPLAHYFISSSHNTYLTDSQIGGTSSTEAYIRAFAQGCRCVELDCWEGPG-- 386

  Fly   375 EEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLL 439
            .||::.|||...::|||:|.|||:.|.||.||.||||||.||||...||..:|::.....||:|:
Mouse   387 GEPVIYHGHTLTSKILFRDVIQAVRDHAFTSSPYPVILSLENHCGLEQQAVMARHLRSILGDMLV 451

  Fly   440 KEPLPDHPLDPGLP--LPPPCKLKRKILIKNKRMKPEVEKVELELWLKGELKTDDDPEEDASAGK 502
            .:     .||...|  ||.|.:||.:||:|.|:: |.....:      |.:.:|.:.||
Mouse   452 TQ-----ALDSQNPEELPSPEQLKGRILVKGKKL-PAARSED------GRILSDREEEE------ 498

  Fly   503 PPEAAAAPAPAPEAAAAAEGAAEGGGGAEAEAAAANYSGSTTNVHPWLSSMVNYAQPIKFQGFDK 567
                        |....||.|.|          ||........:.|.||::..|....:.:..|.
Mouse   499 ------------EEEEEAEEALE----------AAEQRSRAKQISPELSALAVYCCATRLRTLDP 541

  Fly   568 AIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMV 632
            :.....:..:.|.:|.....:.:::...||.:|.:|::|:||.|.|.:|:||.||..||:|||:|
Mouse   542 SPGPPQSCTVGSLSERKARKFTREAGTSFVRHNTQQLTRVYPLGLRMNSANYNPQEMWNSGCQLV 606

  Fly   633 SLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQF 697
            :||||:....|.||.|:|..||.|||:|||.::|:.:..|||....|....:|    ::|:..|.
Mouse   607 ALNFQTPGYEMDLNTGRFLINGQCGYVLKPAYLRQLNTTFDPECPGPPRTTLA----IQVLTAQQ 667

  Fly   698 L----SDKK---VGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRKVVLPDLAVL 755
            |    ::|.   |...|.|::.|:|.|..:||  |..|.|||.||.: |....|| :..|:|.::
Mouse   668 LPKLNAEKPSSIVDPLVRVEIHGVPEDCAQKE--TDYVLNNGFNPCW-EQTLQFR-LRAPELVLV 728

  Fly   756 RFGV--YEES--GKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIELK 806
            ||.|  |:.:  ...:||..|||..|:.||||:.|.::....::...|||:|.::
Mouse   729 RFVVEDYDTTSPNDFVGQSTLPLSSLKQGYRHIHLLSKDGASLAPATLFVHIRIQ 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_525069.2	PH_PLC_beta	17..149	CDD:270167	6/25 (24%)
		EFh_NorpA_like	154..306	CDD:320042	37/159 (23%)
		EF-hand motif	154..183	CDD:320042	7/35 (20%)
		EF-hand motif	189..218	CDD:320042	5/28 (18%)
		EF-hand motif	227..256	CDD:320042	7/28 (25%)
		EF-hand motif	273..306	CDD:320042	15/33 (45%)
		PI-PLCc_beta	318..653	CDD:176533	128/336 (38%)
		C2_PLC_like	689..806	CDD:175974	43/127 (34%)
		DUF1154	865..909	CDD:461969
		PLC-beta_C	952..1073	CDD:462571
Plcd3	NP_690026.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43
		PH_PLC_delta	61..177	CDD:270169	6/25 (24%)
		Substrate binding. /evidence=ECO:0000250	69..97
		EF-hand_10	197..246	CDD:405477	9/55 (16%)
		PLN02228	251..778	CDD:177873	207/587 (35%)
		PI-PLCc_delta3	332..627	CDD:176567	128/336 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	484..517		11/66 (17%)