DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment norpA and plce1

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	XP_021335822.1	Gene:	plce1 / 568288	ZFINID:	ZDB-GENE-061212-4	Length:	2289	Species:	Danio rerio

Alignment Length:	865	Identity:	252/865 - (29%)
Similarity:	381/865 - (44%)	Gaps:	233/865 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 ISLEQFIQFMNDKQRDPRMNEILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDEN 307
            :::.|...|:.:.||:       :..|:|  ...||..:|.....::...||.:||.|:||..:|
Zfish  1292 LAISQLNDFLVNCQRE-------HLSYDE--ILSIIQKFEPSSNMRQMGWMSFEGFARFLMDKDN 1347

  Fly   308 -------APVFLDRLDFYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVEL 365
                   :.|.||      |:..||::|||.|||||||:|.|:.|:||||:|.|.||.|||.|||
Zfish  1348 FASKNEESQVNLD------ELQHPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVEL 1406

  Fly   366 DCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYC 430
            |||:  |:|..|::.|||...|:|.|||.::||...|||:||.|||||.||||:..||.|:|:..
Zfish  1407 DCWD--GDDGMPVIYHGHTLTTKIPFKDVVEAINRAAFVNSEMPVILSIENHCSLPQQRKMAEIF 1469

  Fly   431 DDFFGD-----LLLKEPLPDHPLDPGLPLPPPCKLKRKILIKNKRMKPEVEKVELELWLK----- 485
            ...||:     .|.:....|.||     ||.|.:|:.|||:|||::|.....|::   ||
Zfish  1470 KMVFGEKLVTKFLFESDFADEPL-----LPSPLQLRGKILLKNKKLKAHQAPVDI---LKQKAHQ 1526

  Fly   486 ----------GELKT-----DDDPEEDASAGKPPEAAAAPAPAPEAAAAAEG--------AAEGG 527
                      |.:.|     :|:.||:.........:.:.|....|:.|:.|        ..||.
Zfish  1527 LAHMQAQANNGTVSTTPLGNNDEEEEEEDEYDYDYESLSDADVLNASTASYGQEDNILDDKPEGK 1591

  Fly   528 GGAEAEAAAAN--------YSGS---------------------TTNVHPWLSSMVNYAQPIKFQ 563
            ...|.....:|        .:||                     :..:...||.:|.|.|.|||.
Zfish  1592 SSTEKLQYESNDEMPKRFKKAGSKGKMFDMELGEEFYLPQNEKESRQIAQELSDLVIYCQAIKFP 1656

  Fly   564 GF------------DKAIEKNI------------------------------------------- 573
            |.            |:...|:|
Zfish  1657 GLSTLSPSGSGRGKDRKSRKSIFGSAPARGSPGEPVTLVRAPGKASLEGIRMNSEDQLCLSPSTS 1721

  Fly   574 ---------AHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGC 629
                     .:::||..|:|.....::.|...:.:...|:.|.||..||.||:|..|.:||..|.
Zfish  1722 LSSIIRTPKCYHISSVNENAAKRLCRRYSQKLIQHTSCQLLRTYPAATRIDSANPNPLIFWLHGV 1786

  Fly   630 QMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRAD----KDFDPFADAPVDGVIAAQCSV 690
            |:|:||:|:.|||||||...||.||.||::|||..:....    :.|.|. |..::.:.....::
Zfish  1787 QLVALNYQTDDLPMQLNAALFEANGHCGFVLKPPVLWDRSCPLYQHFYPL-DRDLENMTPTLYTL 1850

  Fly   691 KVIAGQFL--SDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRKVVLPDLA 753
            .:::||.:  .:......|||::.|:|:|:.  .|||:.:..|.|||::||. |.|. |...|||
Zfish  1851 TIVSGQNVCPGNSNGSPCVEVEVLGMPADSC--HFRTKPIHRNTLNPMWNEH-FQFH-VHFEDLA 1911

  Fly   754 VLRFGVYE-ESGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFV---------------- 801
            .||..|.| .|.::..||||||..|:|||||:.||...|.|:.:..||:
Zfish  1912 FLRIAVVENNSSQVTAQRILPLKTLRAGYRHLQLRNLHNEPLEVSSLFMFSRRTEESPTGGPPSA 1976

  Fly   802 -------------NIELKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQM------KALGIEEQSG 847
                         ..::.::...|.|.|..:..|.  |. .|||..:.:      |.:.:||:
Zfish  1977 SVLFSTEERRSVQQHKVTVHGVPGPEPFTVICVDE--FT-TAKQLLDSLFPTASFKYMLMEER-- 2036

  Fly   848 GAARDAGKAKEEEKKEP---PLVFEPVTLE---SLRQEKGFQKVGKKQIKELDTLRKKHAKERTS 906
                   .:..:|||.|   ||..:...|:   |.:.|.|:  ||:..:|   |..:::..|:||
Zfish  2037 -------VSLSKEKKAPQQRPLANDERLLKLIHSWQPEDGY--VGRIYLK---TREQQNCSEKTS 2089

  Fly   907 VQKTQNAAIDKLIKGKSKDD 926
            |..   .::::|  |..:||
Zfish  2090 VPL---ESLEEL--GSLEDD 2104

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167
		PLN02952	224..786	CDD:178538	213/682 (31%)
		EF-hand_like	227..318	CDD:286375	20/81 (25%)
		PI-PLCc_beta	318..653	CDD:176533	143/460 (31%)
		C2_PLC_like	689..806	CDD:175974	46/148 (31%)
		DUF1154	866..908	CDD:284131	12/44 (27%)
		Mer2	<887..1003	CDD:286200	10/40 (25%)
plce1	XP_021335822.1	RasGEF	483..668	CDD:306970
		EFh_PI-PLCepsilon	1166..1346	CDD:320033	16/62 (26%)
		EF-hand motif	1166..1194	CDD:320033
		putative EF-hand motif	1200..1256	CDD:320033
		EF-hand motif	1268..1308	CDD:320033	4/22 (18%)
		EF-hand motif	1313..1346	CDD:320033	11/34 (32%)
		PI-PLC-Y	1355..1960	CDD:332526	201/625 (32%)
		PI-PLCc_epsilon	1359..1810	CDD:176538	145/466 (31%)
		PLC_epsilon_RA	2106..2205	CDD:176375
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920