DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment norpA and plch1

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	XP_021323527.1	Gene:	plch1 / 566479	ZFINID:	ZDB-GENE-060503-398	Length:	1795	Species:	Danio rerio

Alignment Length:	1257	Identity:	307/1257 - (24%)
Similarity:	514/1257 - (40%)	Gaps:	316/1257 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 CVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIRAGGTPKDPKIL 85
            |:  ||..:.|..|.. ...|:|:||          :|||..|:..       |......||...
Zfish    92 CI--RWRPSRKSEKAK-ITIDSLYKV----------TEGRQSDIFH-------RHAEGSFDPSCC 136

  Fly    86 DKVTKKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKIWLDGIRKITHNVK-ANNICP 149
              .|..:|.::..||    .:.||::               .|:.|:.|:|.:...:. .:::..
Zfish   137 --FTIYHGNHMESLD----LVTSNSE---------------EARTWVTGLRYLMAGISDEDSLAK 180

  Fly   150 MMCLRKHWMRLSY-CVEKSG------------------KIPVKTLAKTFASGKTEKLVYTCIKDA 195
            .......||:.:: ..:|:|                  .:|.:.:.:.|....|
Zfish   181 RQRTHDQWMKQTFEEADKNGDGLLNMEEIYQLLHKMNVNLPRRKVKQMFQEADT----------- 234

  Fly   196 GLPDDKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPR 260
               ||:..|:|.|:||     ..|..:..|.|:..|....: .|:|.::.|:...|:..:|   :
Zfish   235 ---DDQQGTLTFEEFT-----VFYKMMSLRRDLFLLLMCFS-DKKDHLTAEELGNFLRVEQ---K 287

  Fly   261 MNEILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPL 325
            |:.:     ..:.|.:|||.:|:.||.|:|..:.::||..|:.|...........:...:||||:
Zfish   288 MSSV-----TPECCLDIINKFEVSEENKQNGVLGIEGFTNYMRSPACDVFNPQHHEINQDMDQPI 347

  Fly   326 AHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEIL 390
            .:|:|.|||||||:|.|:...|..:||...|.|||||||:|||:  |.|.||:|.||:...::|.
Zfish   348 CNYFIASSHNTYLTGDQLLSHSKTDMYAWVLQAGCRCVEVDCWD--GPDGEPMVQHGYTLTSKIT 410

  Fly   391 FKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLL-LKEPLPDHPLDPGLPL 454
            ||..|:.|...|||::|:|||||.||||:..||.|:|::..:.|||.| :.|.|...|..    |
Zfish   411 FKSVIETINKYAFVNNEFPVILSIENHCSIQQQKKIAQHLKEIFGDKLDVGEALNKDPKQ----L 471

  Fly   455 PPPCKLKRKILIKNKRMKPEVEKVELELWLKGELKTDDDPEE--------DASAGKP-------- 503
            |.|..||.|||:|.||: |.....:.|   :||:..||..:|        ::::..|
Zfish   472 PSPNLLKGKILLKGKRL-PSYLSADAE---EGEVSDDDSADEIEDDFKLKNSTSNGPSQHQVESH 532

  Fly   504 ---------PEAAAAPAPAPEA-------AAAAEG------------------------------ 522
                     .|:........::       .|..||
Zfish   533 IRKKLDSLMKESQIGDKEDTDSFSIRALLRATHEGLQRNLRKNSKDGMKKSQSRSFISNLKHKRH 597

  Fly   523 ----------AAEGGGGAEAEAAAANYSG---STTNVHPWLSSMVNYAQPIKFQGFDKAIEKNIA 574
                      ..|.....|......|..|   .|..:...||.:|.:...:..|   :.:::...
Zfish   598 SKSRLKCQSVETEDDSQQEPSGGQFNRGGRRRKTIKLSRDLSDLVVFTNSVASQ---ECLDEGSP 659

  Fly   575 HNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSS 639
            .|:.||:|:...|.:...:..|:.:|:||:|||||...|.||||:.||.:||.|||:|:||:|:.
Zfish   660 CNVLSFSEARAQNLVHHRAERFLTFNQRQLSRIYPSAYRIDSSNFNPQTYWNVGCQLVALNYQTE 724

  Fly   640 DLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQ-------- 696
            ...||||:.||..|||.||:|||..|.:.  .|:|.:|.|:......|..:|:|:||
Zfish   725 GRMMQLNRAKFMVNGGSGYVLKPSLMSKG--AFNPLSDEPLPANPKKQLVIKIISGQQLPKPPDS 787

  Fly   697 FLSDKK--VGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNED-PFVFRKVVLPDLAVLRFG 758
            .|.|:.  :..:|||::.|||.|..|::  ||:|.:||.|||:.|. .|...   :|::|::||.
Zfish   788 MLGDRGEIIDPFVEVEIIGLPVDCCKEQ--TRVVDDNGFNPVWEETLSFTLH---MPEVALVRFL 847

  Fly   759 VYEES--GK-ILGQRILPLDGLQAGYRHVSLR--TEANFPMSLPMLFVNIELKIYVPDGFEDFMA 818
            |::..  |: .:|||.:....|..|||||.|.  |||:       :||:|.    |.|.:..:..
Zfish   848 VWDHDPIGRDFVGQRTIAFSSLMPGYRHVYLEGMTEAS-------IFVHIT----VHDIYGKWSP 901

  Fly   819 MLSDP----------------RGFAGAAKQQNEQMKALGIEEQSGGAARD------------AGK 855
            ::.:|                |||.|...:.::.    .::..:|...|.            :..
Zfish   902 LVLNPSYTIMHLLGANKGRQLRGFRGLFNRSSKS----SVDTHNGVPPRKRSITDHLLRRTASAP 962

  Fly   856 AKEEEKKEPPLVFEPVTLESLRQEKGFQKVGKKQIKELDTLRKKHAKERTSVQKTQNAAIDKLIK 920
            ||..:|.:.||.           |..:.:....:..:...:.|:....:....:..:..:|||:.
Zfish   963 AKGRKKNKMPLA-----------EATYDRKQSTEDSQSTFVEKRMGNRKALQHRPASMPLDKLLH 1016

  Fly   921 G--------KSKDDIRNDANIKNSINDQTKQWT-DMI----ARHRKEEWDMLRQHVQD----SQD 968
            .        :.:.|...|..|.:.:.::.:..: |::    |....:..::...|:||    .:|
Zfish  1017 SNLNLSTPEQEESDPGADTIIDSFLREKPRSISVDLLFETSAFKEPDSHELSADHIQDFDTEPKD 1081

  Fly   969 AMKALMLTVQAAQIKQLEDRHARDIKDLNAKQAKMSADTAKE-VQNDKTLKTKNEKDR------- 1025
            ..:...|.::.::            ..|:..|.:.|.|..|. .:.||...:|...|.
Zfish  1082 LKETPYLVIEGSK------------NSLSDPQKEHSRDFGKSFTEGDKLCSSKRPADHWSGPSDQ 1134

  Fly  1026 ----RLREKRQNNVKRFMEEKKQIGVKQGRAME----------KLKLAHS---------KQIEEF 1067
                .:.:.......:...:||.:...:.....          .|..:||         .|:...
Zfish  1135 CNGGSIVQSEGRECSQLESDKKNLLTTKAATYSSTSSSSYSSGNLTKSHSPKMDLPDQNSQMSLQ 1199

  Fly  1068 STDVQKLMDMYKIEEEAYKTQG 1089
            .:.:.:|:|...:|.| |.|.|
Zfish  1200 DSALSRLIDAVSLENE-YDTCG 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	26/128 (20%)
		PLN02952	224..786	CDD:178538	208/651 (32%)
		EF-hand_like	227..318	CDD:286375	21/90 (23%)
		PI-PLCc_beta	318..653	CDD:176533	133/410 (32%)
		C2_PLC_like	689..806	CDD:175974	46/132 (35%)
		DUF1154	866..908	CDD:284131	3/41 (7%)
		Mer2	<887..1003	CDD:286200	16/132 (12%)
plch1	XP_021323527.1	PH_PLC_eta	64..170	CDD:270170	26/118 (22%)
		EFh_PI-PLCeta1	188..328	CDD:320050	37/167 (22%)
		EF-hand motif	188..217	CDD:320050	4/28 (14%)
		EF-hand motif	224..254	CDD:320050	10/48 (21%)
		EF-hand motif	258..286	CDD:320050	6/28 (21%)
		EF-hand motif	295..328	CDD:320050	13/32 (41%)
		PI-PLCc_GDPD_SF	340..738	CDD:326331	133/410 (32%)
		C2_PLC_like	768..892	CDD:175974	47/139 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820