DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment norpA and plcd1a

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	NP_001103170.1	Gene:	plcd1a / 555443	ZFINID:	ZDB-GENE-071004-78	Length:	775	Species:	Danio rerio

Alignment Length:	826	Identity:	252/826 - (30%)
Similarity:	387/826 - (46%)	Gaps:	157/826 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ETKENDFERDALFKVDEYGFFLYWKSE---GRDGDVIELCQVSDIRAGGTPKDPKILDKVTKKNG 93
            :.|.|.:::....|::|....:|..|.   .|:.. .||.::..:|.|   :..:.|.|.|..:
Zfish    52 KVKSNSWKKTRFLKLNEDCKTIYQSSSKAFKRESS-FELAEIDSVRLG---RQSEGLQKYTYSS- 111

  Fly    94 TNIPELDKRSLTIC-----SNTDYINITYHHVICPDAATAKIWLDGIRKITH-----NVKANNIC 148
                 ::.|..:|.     .|.|        :|......|..|::.:.|:.:     |.:.|:
Zfish   112 -----IENRCFSIIFKGRRENLD--------LIASSDDEANCWVNSLEKVINRLHKLNRQQNS-- 161

  Fly   149 PMMCLRKHWMRLSYCVEKS-----GKIPVKTLAKTFA--------SGKTEKLVYTCIKDAGLPDD 200
                  :||  :..|:.|:     .|:.:|.| |.|.        ....|.|...|        |
Zfish   162 ------EHW--IYECMRKADKNADNKMSLKEL-KHFLRQINIEVNDSYAETLFRKC--------D 209

  Fly   201 KNATMTKEQFTFDKFYALYHKVCPRNDIEELFT--SITKGKQDFISLEQFIQFMNDKQRDPRMNE 263
            .:.:.|.|......||.|   :..|::|:.::.  :.:.|:.....|..|||.   :||:|
Zfish   210 TSNSGTLEGSEIKLFYNL---LTQRDEIDVIYDKYATSNGQMSRNDLLNFIQL---EQREP---- 264

  Fly   264 ILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHY 328
             :...|.|    |:|..||:||..|::..||.|||..|| :.|...:....:|.|.:|.|||.||
Zfish   265 -VSLGYAE----ELIKKYEVDETAKQDKHMSKDGFLMYL-NQEGTLLNPAHIDVYQDMQQPLNHY 323

  Fly   329 YINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKD 393
            :|:|||||||...|:.|.||.|.|.:.|:..|||||||.|:  |.:.||::.:||...:::.|||
Zfish   324 FISSSHNTYLMEDQLKGPSSTEAYIKALMKSCRCVELDIWD--GANGEPVIYYGHTLTSKVPFKD 386

  Fly   394 CIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLP--LPP 456
            .|:||.|.||.:|.||||||.||||:..||..:|.:.....|..||.:||...     :|  .|.
Zfish   387 VIKAIKDYAFKASPYPVILSLENHCSLEQQKIVAMHLTTILGSALLTQPLGQK-----MPTTFPG 446

  Fly   457 PCKLKRKILIKNKRMK-----------PEVEKVELELWLKGELKTDDDPEEDASAGKPPEAAAAP 510
            |..||.:.|||.||:.           .:||.|           :::|...|...|:|....:..
Zfish   447 PEDLKGRFLIKGKRLNKLDAAFNNNTAEDVESV-----------SEEDEAADLKEGEPTHKDSKK 500

  Fly   511 APAPEAAAAAEGAAEGGGGAEAEAAAANYSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEKNIAH 575
            :...:.|..                              ||.:|.|.:.:.|..|:::.:|...:
Zfish   501 SKKIKLAKE------------------------------LSDLVVYCKSVHFTSFEQSRKKQAFY 535

  Fly   576 NMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSD 640
            .|:||.|...||..:||:..|:.:|..::|||||.|:|.|||||.|...||||||:|:|||.:..
Zfish   536 EMASFKEGKAMNLAEQSANAFIRHNIDKLSRIYPAGSRTDSSNYNPVPLWNAGCQIVALNFLTPC 600

  Fly   641 LPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQFL------S 699
            ..|.|||.:|..||..||:|||:|:|.....|||........:......:.||:.|.|      .
Zfish   601 KEMDLNQARFLPNGKSGYILKPEFLRDPASQFDPINLRKGPWLQKKVLHIMVISAQQLPKINKNK 665

  Fly   700 DKK-VGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRKVVLPDLAVLRFGV--YE 761
            :|. |..:|.|:::|:|.|...|:  |..:.|||.||::|.: |.| .|.:|:||::||.|  |:
Zfish   666 EKSIVDPHVRVEIYGVPQDNASKQ--THHIDNNGFNPMWNTN-FQF-TVNVPELALVRFVVEDYD 726

  Fly   762 ESGK--ILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIEL 805
            .:.|  ::|...:||..:|.||||:.|.|:....:....|||::.|
Zfish   727 AASKNDLIGLYTIPLTSMQNGYRHMPLLTKRGIIIPSAGLFVHVML 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	24/129 (19%)
		PLN02952	224..786	CDD:178538	204/587 (35%)
		EF-hand_like	227..318	CDD:286375	27/92 (29%)
		PI-PLCc_beta	318..653	CDD:176533	126/347 (36%)
		C2_PLC_like	689..806	CDD:175974	44/128 (34%)
		DUF1154	866..908	CDD:284131
		Mer2	<887..1003	CDD:286200
plcd1a	NP_001103170.1	PH_PLC_delta	44..159	CDD:270169	23/124 (19%)
		PH	44..149	CDD:278594	22/114 (19%)
		EF-hand_10	179..228	CDD:291454	14/60 (23%)
		PLN02952	232..768	CDD:178538	206/600 (34%)
		EF-hand_like	233..313	CDD:286375	27/92 (29%)
		PI-PLCc_delta	313..613	CDD:176535	126/347 (36%)
		C2_PLC_like	645..770	CDD:175974	43/128 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920