DRSC/TRiP Functional Genomics Resources

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Protein Alignment norpA and PLCG2

DIOPT Version :9

Sequence 1:NP_001014720.1 Gene:norpA / 31376 FlyBaseID:FBgn0262738 Length:1095 Species:Drosophila melanogaster
Sequence 2:NP_002652.2 Gene:PLCG2 / 5336 HGNCID:9066 Length:1265 Species:Homo sapiens


Alignment Length:1274 Identity:279/1274 - (21%)
Similarity:439/1274 - (34%) Gaps:514/1274 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 KSEGRDGDVIELCQVSDIRAGGTPKDPKILDKVTKKN--------GTNIPELDKRSLTICSNTDY 112
            |.||    .:::.::.:||.|...||.:....|.:|.        ||.. .|...||...|..|.
Human    60 KIEG----FLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQF-VLSTLSLAADSKEDA 119

  Fly   113 INITYHHVICPDAATAKIWLDGIRKITHNVKANNICPMMCLRKHWMRLS-YCVEKS--GKIPVKT 174
            :|                ||.|: ||.|....|...|.:.  :.|:|.. |.|:::  ..|.::.
Human   120 VN----------------WLSGL-KILHQEAMNASTPTII--ESWLRKQIYSVDQTRRNSISLRE 165

  Fly   175 LAKTFASGKTEKLVYTCIKDAGLPDDKNATM--TKEQFTFDKFYALYHKVCPRNDIEELFTSITK 237
            | ||..     .|:...:..|....||...:  .|::.:|::|:..|.|:.    .|:..:.:.:
Human   166 L-KTIL-----PLINFKVSSAKFLKDKFVEIGAHKDELSFEQFHLFYKKLM----FEQQKSILDE 220

  Fly   238 GKQD---------------FISLEQFIQFMNDKQRD---PRMNEILYPLYEEKRCTEIINDYELD 284
            .|:|               .:.|..|.:|:..:|::   ..:|::      .:|.|:.|     |
Human   221 FKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKV------RERMTKFI-----D 274

  Fly   285 EEKKKNVQ--MSLDGFKRYLMSDENAPVFLDRLDF--YMEMDQPLAHYYINSSHNTYLSGRQIGG 345
            :..::..:  :.:|.|..||.|.||: ::.::.|.  ..:|:.||:||:|:|||||||:|.|:..
Human   275 DTMRETAEPFLFVDEFLTYLFSRENS-IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRS 338

  Fly   346 KSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPV 410
            :||.|.|.:.|..||||:|||||:  |.|.:|::.||....|:|.|.|.:|||.|.|||:|.:||
Human   339 ESSPEAYIRCLRMGCRCIELDCWD--GPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPV 401

  Fly   411 ILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRKILIKNKRMKP-- 473
            |||.|.||:..||..:||...:.||||||.:| .:...|   .||.|.:|:.||:||:|::.|  
Human   402 ILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKP-TEASAD---QLPSPSQLREKIIIKHKKLGPRG 462

  Fly   474 ------------EVEKVELELW--------------LKGELKTDDDPEEDASAGKPPEAAAAPA- 511
                        ..::.||.:|              ...:|...||.|:......|.:...... 
Human   463 DVDVNMEDKKDEHKQQGELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELH 527

  Fly   512 -------PAPEAAAAAEG-----AAEGGGG------AEAEAAAANYS------------------ 540
                   ...|...:||.     ..|.||.      .|:|....:|:                  
Human   528 FGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTM 592

  Fly   541 -GST-----------------------------------------TNVH---PW----------- 549
             |.|                                         .|.|   ||           
Human   593 EGGTLKYYLTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAE 657

  Fly   550 ----------------------------------------------------LSSMV-------- 554
                                                                ..|:|        
Human   658 DMLMRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEK 722

  Fly   555 ----------------------------------------------------------------- 554
                                                                             
Human   723 HSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDE 787

  Fly   555 ----------------------------------NYAQPIK---FQGFDKAI------------- 569
                                              ||.:.|.   |:..:|.|             
Human   788 LSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQIIEDNPLGSLCRGI 852

  Fly   570 ----------------------------------------------------------------- 569
                                                                             
Human   853 LDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNM 917

  Fly   570 ---EKN--IAHNMS-------------------------SFAESAGMNYLKQSSIDFVNYNKRQM 604
               |||  ||..:|                         ||.|:...:.::|..:|.:.||::.:
Human   918 KYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGL 982

  Fly   605 SRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRAD 669
            :|:||||.|.|||||.|...|..|.|||:||||::|..||:|...|..||..||:|:|:.||  .
Human   983 TRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMR--T 1045

  Fly   670 KDFDPFADAPVDG--VIAAQCSVKVIAGQFLSDKKVG-----TYVEVDMFGLPSDTVKKEFRTRL 727
            :.:||.   |.:.  .|....:|||:..:.|  .|:|     .:|||::.|...|..|  |:|.:
Human  1046 EKYDPM---PPESQRKILMTLTVKVLGARHL--PKLGRSIACPFVEVEICGAEYDNNK--FKTTV 1103

  Fly   728 VANNGLNPVY--NEDPFVFRKVVLPDLAVLRFGVYEE----SGKILGQRILPLDGLQAGYRHVSL 786
            |.:|||:|::  .::...| ::..|:||.|||.||||    ....|.....|:..:::|:|.|.|
Human  1104 VNDNGLSPIWAPTQEKVTF-EIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSGFRSVPL 1167

  Fly   787 RTEANFPMSLPMLFVNIELKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIEEQSGGAAR 851
            :...:..:.|..|.|..|::..:    |....:.|..|......::.|.|:......:....|.|
Human  1168 KNGYSEDIELASLLVFCEMRPVL----ESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRNANR 1228

  Fly   852 DAGKAKEEEKKEPPLVFEPVTLESLRQEKGFQKVGKKQI 890
            || ..||....|..|        .|.|||..:::.:|::
Human  1229 DA-LVKEFSVNENQL--------QLYQEKCNKRLREKRV 1258

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
norpANP_001014720.1 PH_PLC_beta 17..149 CDD:270167 25/100 (25%)
PLN02952 224..786 CDD:178538 213/987 (22%)
EF-hand_like 227..318 CDD:286375 20/112 (18%)
PI-PLCc_beta 318..653 CDD:176533 146/725 (20%)
C2_PLC_like 689..806 CDD:175974 40/127 (31%)
DUF1154 866..908 CDD:284131 6/25 (24%)
Mer2 <887..1003 CDD:286200 1/4 (25%)
PLCG2NP_002652.2 PH_PLC_gamma 22..140 CDD:270168 25/101 (25%)
PH-like 235..>276 CDD:302622 9/51 (18%)
PI-PLCc_gamma 311..>458 CDD:176534 75/152 (49%)
PH-like 475..>510 CDD:302622 6/34 (18%)
SH2_N-SH2_PLC_gamma_like 527..627 CDD:199829 11/99 (11%)
SH2_C-SH2_PLC_gamma_like 641..744 CDD:198186 5/102 (5%)
SH3_PLCgamma2 773..827 CDD:212902 2/53 (4%)
PHsplit_PLC_gamma <840..910 CDD:270054 0/69 (0%)
PI-PLCc_GDPD_SF <926..1031 CDD:301322 36/104 (35%)
C2_PLC_like 1061..1187 CDD:175974 40/130 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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