DRSC/TRiP Functional Genomics Resources

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Protein Alignment norpA and PLCG1

DIOPT Version :9

Sequence 1:NP_001014720.1 Gene:norpA / 31376 FlyBaseID:FBgn0262738 Length:1095 Species:Drosophila melanogaster
Sequence 2:XP_005260495.1 Gene:PLCG1 / 5335 HGNCID:9065 Length:1330 Species:Homo sapiens


Alignment Length:1415 Identity:300/1415 - (21%)
Similarity:445/1415 - (31%) Gaps:658/1415 - (46%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 PELTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIRAGGTP 79
            ||..|       |:.:.||::..:.|.|    |        |.||    .|::.::.:||.|.|.
Human    46 PERKT-------FQVKLETRQITWSRGA----D--------KIEG----AIDIREIKEIRPGKTS 87

  Fly    80 KDPKILDKVTKKNGTNIP------------ELDKRSLTI-CSNTDYINITYHHVI--------CP 123
            :|   .|:. :::....|            |...::|:: .::.|.:|:....:.        .|
Human    88 RD---FDRY-QEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAP 148

  Fly   124 DAATAKIWLDGIRKITHNVKAN-------------------NICPMMCLRKHWMRLSYCVEKSGK 169
            .....:.||   ||..::|..|                   .:..|..||:   ||:...::||.
Human   149 TPLQIERWL---RKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRE---RLTDLEQRSGD 207

  Fly   170 IPVKTLAKTFASGKTEKLVYTCIKDAGLPDDKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTS 234
            |.....|:.:.|     |:|:..|...||..:.:|:...:         ..::|.          
Human   208 ITYGQFAQLYRS-----LMYSAQKTMDLPFLEASTLRAGE---------RPELCR---------- 248

  Fly   235 ITKGKQDFISLEQFIQFMNDKQ-------------------RDPRMNEILYPLYEEKRCTEIIND 280
                    :||.:|.||:.|.|                   ||| :.||..|.:           
Human   249 --------VSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDP-LREIEEPYF----------- 293

  Fly   281 YELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYM--EMDQPLAHYYINSSHNTYLSGRQI 343
                         .||.|..:|.|.||: |:..:||...  .|:.||:||:|:|||||||:|.|.
Human   294 -------------FLDEFVTFLFSKENS-VWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQF 344

  Fly   344 GGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEY 408
            ..:||:|.|.:.|..||||:|||||:  |.|..|::.|||...|:|.|.|.:..|.:.|||:|||
Human   345 SSESSLEAYARCLRMGCRCIELDCWD--GPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEY 407

  Fly   409 PVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRKILIKNKRM-- 471
            |||||.|:||:.|||..:|:|.....||.||.:|: :...|   .||.|.:||||||||:|::  
Human   408 PVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPV-EISAD---GLPSPNQLKRKILIKHKKLAE 468

  Fly   472 -------------------------------------------------------------KPEV 475
                                                                         :.|.
Human   469 GSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEE 533

  Fly   476 EKVEL---------ELWLKGELKTDDDPEEDA---------SAGKPP------------------ 504
            |..|:         |.|..|:|....|....|         ..|.|.                  
Human   534 EPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLS 598

  Fly   505 ---------------EAAAAP-----------------------------------APAPEAAA- 518
                           :.|..|                                   .|.|:..| 
Human   599 FWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAH 663

  Fly   519 -------------------------------------------AAEG------------------ 522
                                                       .|||                  
Human   664 ESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGN 728

  Fly   523 -------------------------------AAEGGGGAEAEAAA-------------------- 536
                                           |.|..|.||.:..|                    
Human   729 SEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFK 793

  Fly   537 -------------------------------------------------ANY------------- 539
                                                             :||             
Human   794 CAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPE 858

  Fly   540 ---------------------------------------SGSTTNVHPW---------------- 549
                                                   |.|..:|..|                
Human   859 REHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWV 923

  Fly   550 -----------------------------LSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAG 585
                                         ||.:|.|.:|:.|.......|:....:||||.|:..
Human   924 KKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKA 988

  Fly   586 MNYL-KQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGK 649
            ..|: |.....|:.||:.|:|||||||.|.|||||.|...|..|.|:|:||||:.|.|||:||..
Human   989 EKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQAL 1053

  Fly   650 FEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQFLSDKKVG---TYVEVDM 711
            |.....|||:|:|..||  |:.||||..:.:.|:.....|::|:..:.|.....|   .:||:::
Human  1054 FMTGRHCGYVLQPSTMR--DEAFDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEV 1116

  Fly   712 FGLPSDTVK-------------------------------------KEFRTRLVANNGLNPVYNE 739
            .|...|:.|                                     |.|......:||||||:..
Human  1117 AGAEYDSTKQKTEFVGQSVFPVILLILLGHCKPLPTSHPILSHGDLKPFVVAFTVDNGLNPVWPA 1181

  Fly   740 DPFVFRKVVLPDLAVLRFGVYEE----SGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLF 800
            .||.| ::..|:.|.|||.||||    ....|.|...|:.||:.|||.|.|:...:..:.|..|.
Human  1182 KPFHF-QISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLL 1245

  Fly   801 VNIELKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQM---KALGIEEQSGGAARDA--GKAKE-- 858
            :.|::   .|                   |||:|..:   ....:.|:...|:...  |:|:|  
Human  1246 IKIDI---FP-------------------AKQENGDLSPFSGTSLRERGSDASGQLFHGRAREGS 1288

  Fly   859 -EEKKEPPLVFEPVTLESLRQEKGFQKVGKKQIKELDTLRKKHAKERTSV 907
             |.:.:.|  ||..            ::.::.:.:....|::.|..||.|
Human  1289 FESRYQQP--FEDF------------RISQEHLADHFDSRERRAPRRTRV 1324

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
norpANP_001014720.1 PH_PLC_beta 17..149 CDD:270167 29/171 (17%)
PLN02952 224..786 CDD:178538 229/1035 (22%)
EF-hand_like 227..318 CDD:286375 23/109 (21%)
PI-PLCc_beta 318..653 CDD:176533 155/745 (21%)
C2_PLC_like 689..806 CDD:175974 42/160 (26%)
DUF1154 866..908 CDD:284131 7/42 (17%)
Mer2 <887..1003 CDD:286200 5/21 (24%)
PLCG1XP_005260495.1 PH_PLC_gamma 29..151 CDD:270168 25/131 (19%)
PH <71..142 CDD:278594 13/78 (17%)
PI-PLCc_gamma 319..>466 CDD:176534 77/152 (51%)
PH-like 489..>523 CDD:302622 0/33 (0%)
SH2_N-SH2_PLC_gamma_like 545..649 CDD:199829 10/103 (10%)
SH2_C-SH2_PLC_gamma_like 663..765 CDD:198186 5/101 (5%)
SH3_PLCgamma1 791..850 CDD:212903 2/58 (3%)
PHsplit_PLC_gamma <864..933 CDD:270054 4/68 (6%)
PLCYc 954..1069 CDD:128454 51/114 (45%)
C2_PLC_like 1087..1250 CDD:175974 42/163 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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