DRSC/TRiP Functional Genomics Resources

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Protein Alignment norpA and PLCL1

DIOPT Version :10

Sequence 1:NP_525069.2 Gene:norpA / 31376 FlyBaseID:FBgn0262738 Length:1095 Species:Drosophila melanogaster
Sequence 2:NP_006217.3 Gene:PLCL1 / 5334 HGNCID:9063 Length:1095 Species:Homo sapiens


Alignment Length:1134 Identity:285/1134 - (25%)
Similarity:452/1134 - (39%) Gaps:290/1134 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 LTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGD--VIELCQVSDIRAG--- 76
            :..||..       |:.:.|....:..|.:|.....|.|:...:|.:  .:::..:.:||.|   
Human   115 MQAGCEL-------KKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNT 172

  Fly    77 GTPKDPKILDKVTKK------NGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKSWQKNL 135
            .|.::..:.|::.:.      :|.|...||    .:.::.|..||               |...|
Human   173 ETFRNNGLADQICEDCAFSILHGENYESLD----LVANSADVANI---------------WVSGL 218

  Fly   136 RLITHNNR-------ATNVCPRVNLMKHWMRLSY----------CVEKSGKIPVKTLAKTFASGK 183
            |.:...::       .....||.    .|::..:          .:|.:....:|.|..|....|
Human   219 RYLVSRSKQPLDFMEGNQNTPRF----MWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAK 279

  Fly   184 TEKLVYTCIKDAGLPDDKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQF 248
            ..      :|...:...|....|:  .|.::|...:.::|.|.::..|...|:|.| :::.....
Human   280 IR------LKFKEIQKSKEKLTTR--VTEEEFCEAFCELCTRPEVYFLLVQISKNK-EYLDANDL 335

  Fly   249 IQFMNDKQRDPRMNEILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLD 313
            :.|:..:|....:.|.:        |.:||..|||.||.::...:::|||.:||:|.|......:
Human   336 MLFLEAEQGVTHITEDI--------CLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPE 392

  Fly   314 RLDFYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPI 378
            :.....:|.|||:|||||:||||||...|..|.:.:..|.:.|..|||.||||.  ..|.|.|||
Human   393 QKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDV--SDGSDNEPI 455

  Fly   379 VTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKE-P 442
            :.:.:...|.:.|:..|:.|...|||:||||:||...|||:..||..:|:.....||:.|..| |
Human   456 LCNRNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAP 520

  Fly   443 LPDHPLDPGLPLPPPCKLKRKILIKNKRM--KPEVEKVELELWLKGELKTDDDPEEDASAGKPPE 505
            ||....     ||.|.||||.|::|.|::  .|:|        |:||: ||:|.|.:.|      
Human   521 LPSESY-----LPSPEKLKRMIIVKGKKLPSDPDV--------LEGEV-TDEDEEAEMS------ 565

  Fly   506 AAAAPAPAPEAAAAAEGAAEGGGGAEAEAAAANYSGSTTNVH--PWLSSMVNYAQPIKFQGFDKA 568
                                       ...:.:|:|....:.  ..||.:|:..:.::::.|:.:
Human   566 ---------------------------RRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRDFELS 603

  Fly   569 IEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVS 633
            ::......|.||:|:.......:...|||||||:.:|||||...|.||||..||.|||.|||:|:
Human   604 MKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVA 668

  Fly   634 LNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQFL 698
            :|||:....|.|:.|.|..||||||:|:|..||.....|.......:.||......:|:|:||..
Human   669 MNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNF 733

  Fly   699 SDKK--------VGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRKVVLPDLAVL 755
            ...|        :..||.:::.|:|:|.  .|.||:.|..|..||:::| .|.| :|.||:||::
Human   734 PKPKGACAKGDVIDPYVCIEIHGIPADC--SEQRTKTVQQNSDNPIFDE-TFEF-QVNLPELAMI 794

  Fly   756 RFGVYEE---SGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIELKIYVPDGFEDFM 817
            ||.|.::   ..:.:||..:|.:.||.|||||.||:.....|....|||:|              
Human   795 RFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHI-------------- 845

  Fly   818 AMLSDPRGFAGAAKQQNEQMKALGIEEQSGGAARDAGKAKEEEKKEPPLVFEPVTLESLRQEKGF 882
                                   .|..:|||                                  
Human   846 -----------------------AITNRSGG---------------------------------- 853

  Fly   883 QKVGKKQIKELDTLRKKHAKERTSVQKTQNAAIDKLIKGKSKDDIRNDANIKNSINDQTKQWTDM 947
               ||.|.:.|.....|..:|.|.::......||.:.|                           
Human   854 ---GKAQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFK--------------------------- 888

  Fly   948 IARHRKEEWDMLRQHVQDSQDAMKALMLTVQAAQIKQLEDRHARDIKDLNAKQAKMSADTAKEVQ 1012
            ||.|...|...:|:::|::..::|.|......|.:||..         |......:::|....|.
Human   889 IAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQCL---------LTLSSRLITSDNTPSVS 944

  Fly  1013 ----------------NDKTLKTKNEKDRRLREKR----------------QNNVKRFMEEKKQI 1045
                            .|...|.....|..::|.|                |.....|.||...:
Human   945 LVMKDSFPYLEPLGAIPDVQKKMLTAYDLMIQESRFLIEMADTVQEKIVQCQKAGMEFHEELHNL 1009

  Fly  1046 GVKQGRAMEKLKLAHSKQIEEFSTDVQKL 1074
            |.|:|....||    :|..|.|:.::..|
Human  1010 GAKEGLKGRKL----NKATESFAWNITVL 1034

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
norpANP_525069.2 PH_PLC_beta 17..149 CDD:270167 24/149 (16%)
EFh_NorpA_like 154..306 CDD:320042 34/161 (21%)
EF-hand motif 154..183 CDD:320042 5/38 (13%)
EF-hand motif 189..218 CDD:320042 5/28 (18%)
EF-hand motif 227..256 CDD:320042 5/28 (18%)
EF-hand motif 273..306 CDD:320042 14/32 (44%)
PI-PLCc_beta 318..653 CDD:176533 120/339 (35%)
C2_PLC_like 689..806 CDD:175974 45/127 (35%)
DUF1154 865..909 CDD:461969 7/43 (16%)
PLC-beta_C 952..1073 CDD:462571 28/152 (18%)
PLCL1NP_006217.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..61
Interaction with PPP1C 83..222 24/132 (18%)
PH_PLC_eta 115..223 CDD:270170 24/133 (18%)
EFh_PRIP1 243..385 CDD:320052 34/158 (22%)
EF-hand motif 243..272 CDD:320052 3/28 (11%)
EF-hand motif 279..311 CDD:320052 6/39 (15%)
EF-hand motif 315..343 CDD:320052 5/28 (18%)
EF-hand motif 352..385 CDD:320052 14/40 (35%)
PI-PLCc_PRIP_metazoa 398..688 CDD:176539 120/338 (36%)
Interaction with GABA A beta subunit. /evidence=ECO:0000250 543..567 10/65 (15%)
C2_PLC_like 720..848 CDD:175974 45/168 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1066..1095
Blue background indicates that the domain is not in the aligned region.

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