DRSC/TRiP Functional Genomics Resources

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Protein Alignment norpA and PLCB3

DIOPT Version :10

Sequence 1:NP_525069.2 Gene:norpA / 31376 FlyBaseID:FBgn0262738 Length:1095 Species:Drosophila melanogaster
Sequence 2:NP_000923.1 Gene:PLCB3 / 5331 HGNCID:9056 Length:1234 Species:Homo sapiens


Alignment Length:1190 Identity:425/1190 - (35%)
Similarity:637/1190 - (53%) Gaps:156/1190 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 PP----ELTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIR 74
            ||    .|..|..|.:|   ::||...:.   ...:||..||||||.....:.|.:::..:.|.|
Human    15 PPTVVETLRRGSKFIKW---DEETSSRNL---VTLRVDPNGFFLYWTGPNMEVDTLDISSIRDTR 73

  Fly    75 AG---GTPKDPKILDKVTKKNGTNIPE--LDKRSLTICSNTDYINITYHHVICPDAATAKSWQKN 134
            .|   ..||||||.:.:    |...|:  |:::.:|:.|..|.:|..:.:.:.....|||.|.:.
Human    74 TGRYARLPKDPKIREVL----GFGGPDARLEEKLMTVVSGPDPVNTVFLNFMAVQDDTAKVWSEE 134

  Fly   135 LRLITHNNRATNVCPRVNLMKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDAGLPD 199
            |..:..|..|.|......|.|.:.:|...|.:.|:||||.:.|.|::.|  |.|.|.::..||..
Human   135 LFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADK--KRVETALESCGLKF 197

  Fly   200 DKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSI-TKGKQDFISLEQFIQFMNDKQRDPRMNE 263
            :::.::..::|:.:.|....:|:|.|.||:::...| .||| .:::|||.:.|:|.||||||:||
Human   198 NRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGK-PYLTLEQLMDFINQKQRDPRLNE 261

  Fly   264 ILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHY 328
            :|||.....:...:|..||.:::..:..|||::||.|||..:||..:.|:.||...:|.|||:.|
Human   262 VLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAY 326

  Fly   329 YINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKD 393
            :|||||||||:..|:.|.||||||||.||.||||||||.|.|:..:|||.:|||....||:..:|
Human   327 FINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRD 391

  Fly   394 CIQAIADCAFVSSEYPVILSFENHCNRA-QQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPP 457
            .::|||:.||.:|.||||||||||.:.| ||.|:|:||...|||.||.|||..:||.||:|||.|
Human   392 VLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSP 456

  Fly   458 CKLKRKILIKN-KRMKPEVEKVELELWLKGELKTDDDPEEDASAGKPPEAAAAPAPA-------- 513
            ..|..:||:|| ||.:|.....: ....|..|:..:....::||...|.:....:|:        
Human   457 QDLMGRILVKNKKRHRPSAGGPD-SAGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLS 520

  Fly   514 -------------PEAAAAAEGAAEGG---GGAEAE-----------------AAAANYSGSTTN 545
                         |:.:...||...|.   |.|:.|                 ......:.|..|
Human   521 NGEEVGLEKPSLEPQKSLGDEGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVN 585

  Fly   546 VHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPK 610
            ....:|::|||.:|:||:.|:.|.::|....||||.|:..|..|.:|.::||.|||:|:||||||
Human   586 ATEEMSTLVNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPK 650

  Fly   611 GTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPF 675
            |||.||||||||:|||.|||:|:||||:.|:.||||.|.|||||..||||||:||||.||.||||
Human   651 GTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPF 715

  Fly   676 ADAPVDGVIAAQCSVKVIAGQFLSDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNED 740
            .:..|||::|....||||:||||||:|||.||||||||||.|| ::::|||....|..|||::|:
Human   716 TEVIVDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDT-RRKYRTRTSQGNSFNPVWDEE 779

  Fly   741 PFVFRKVVLPDLAVLRFGVYEESGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIEL 805
            ||.|.|||||.||.||...:||.||.:|.||||:..:::||.:|.||.|||.|:.||.|.:..|.
Human   780 PFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYTEA 844

  Fly   806 KIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIEEQSGGAARDAGKAKEEEK--------- 861
            ..|:||..:|:...|.:|........|:..|:.|| |.|....|.::..:..:.::         
Human   845 SDYIPDDHQDYAEALINPIKHVSLMDQRARQLAAL-IGESEAQAGQETCQDTQSQQLGSQPSSNP 908

  Fly   862 ---------KEPP-----------------------LVFE--PVTLESLRQEKGFQKVGKKQIKE 892
                     :.||                       ::.|  |..|:.||..|...|:..:|.::
Human   909 TPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTPLDELRGHKALVKLRSRQERD 973

  Fly   893 LDTLRKKHAKERTSVQKTQNAAIDKLIKGKSKDDIR-------NDANIKNSI--NDQTKQWTDMI 948
            |..|||||  :|.:|..|:. .:|.|.:.:::...|       ..|:::::.  .|:.|::.:..
Human   974 LRELRKKH--QRKAVTLTRR-LLDGLAQAQAEGRCRLRPGALGGAADVEDTKEGEDEAKRYQEFQ 1035

  Fly   949 ARH-------RKEEWDMLRQ----HVQDSQDAMKALMLTVQAAQIKQLEDRHARDIKDL------ 996
            .|.       |:.:.|...|    |::.:...::.::|.....|.|:|::.:.|:.|:|      
Human  1036 NRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQFKRLKEMNEREKKELQKILDR 1100

  Fly   997 ----NAKQAKMSADTAKEVQNDKTLKTKNEKDRRLREKRQNNVKRFMEEKKQ----IGVKQGRAM 1053
                :..:|||.....||.:       ..|.:||...:..|:::|..|.:||    :...|.:.:
Human  1101 KRHNSISEAKMRDKHKKEAE-------LTEINRRHITESVNSIRRLEEAQKQRHDRLVAGQQQVL 1158

  Fly  1054 EKLKLAHSKQIEEFSTDVQK 1073
            ::|.....|.:.:.:.:.|:
Human  1159 QQLAEEEPKLLAQLAQECQE 1178

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
norpANP_525069.2 PH_PLC_beta 17..149 CDD:270167 39/136 (29%)
EFh_NorpA_like 154..306 CDD:320042 54/152 (36%)
EF-hand motif 154..183 CDD:320042 10/28 (36%)
EF-hand motif 189..218 CDD:320042 5/28 (18%)
EF-hand motif 227..256 CDD:320042 11/29 (38%)
EF-hand motif 273..306 CDD:320042 11/32 (34%)
PI-PLCc_beta 318..653 CDD:176533 167/377 (44%)
C2_PLC_like 689..806 CDD:175974 67/116 (58%)
DUF1154 865..909 CDD:461969 17/68 (25%)
PLC-beta_C 952..1073 CDD:462571 27/138 (20%)
PLCB3NP_000923.1 PH_PLC_beta 22..149 CDD:270167 39/136 (29%)
EFh_PI-PLCbeta3 154..304 CDD:320040 54/152 (36%)
EF-hand motif 154..183 CDD:320040 10/28 (36%)
EF-hand motif 187..216 CDD:320040 5/28 (18%)
EF-hand motif 225..254 CDD:320040 11/29 (38%)
EF-hand motif 271..304 CDD:320040 11/32 (34%)
PI-PLCc_beta3 316..693 CDD:176562 167/377 (44%)
PLN02952 <318..833 CDD:178538 252/516 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 467..587 19/120 (16%)
PRK06975 <873..>1066 CDD:235899 36/196 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 887..937 3/49 (6%)
DUF1154 951..990 CDD:461969 15/40 (38%)
PLC-beta_C 1029..1202 CDD:462571 30/157 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1198..1234
Interaction with SHANK2. /evidence=ECO:0000250 1231..1234
Blue background indicates that the domain is not in the aligned region.

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