DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment norpA and PLCB3

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	NP_000923.1	Gene:	PLCB3 / 5331	HGNCID:	9056	Length:	1234	Species:	Homo sapiens

Alignment Length:	1190	Identity:	426/1190 - (35%)
Similarity:	641/1190 - (53%)	Gaps:	156/1190 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PP----ELTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIR 74
            ||    .|..|..|.:|   ::||...:.   ...:||..||||||.....:.|.:::..:.|.|
Human    15 PPTVVETLRRGSKFIKW---DEETSSRNL---VTLRVDPNGFFLYWTGPNMEVDTLDISSIRDTR 73

  Fly    75 AG---GTPKDPKILDKVTKKNGTNIPE--LDKRSLTICSNTDYINITYHHVICPDAATAKIWLDG 134
            .|   ..||||||.:.:    |...|:  |:::.:|:.|..|.:|..:.:.:.....|||:|.:.
Human    74 TGRYARLPKDPKIREVL----GFGGPDARLEEKLMTVVSGPDPVNTVFLNFMAVQDDTAKVWSEE 134

  Fly   135 IRKITHNVKANNICPMMCLRKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDAGLPD 199
            :.|:..|:.|.|......|||.:.:|...|.:.|:||||.:.|.|::.|  |.|.|.::..||..
Human   135 LFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADK--KRVETALESCGLKF 197

  Fly   200 DKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSI-TKGKQDFISLEQFIQFMNDKQRDPRMNE 263
            :::.::..::|:.:.|....:|:|.|.||:::...| .||| .:::|||.:.|:|.||||||:||
Human   198 NRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGK-PYLTLEQLMDFINQKQRDPRLNE 261

  Fly   264 ILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHY 328
            :|||.....:...:|..||.:::..:..|||::||.|||..:||..:.|:.||...:|.|||:.|
Human   262 VLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAY 326

  Fly   329 YINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKD 393
            :|||||||||:..|:.|.||||||||.||.||||||||.|.|:..:|||.:|||....||:..:|
Human   327 FINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRD 391

  Fly   394 CIQAIADCAFVSSEYPVILSFENHCNRA-QQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPP 457
            .::|||:.||.:|.||||||||||.:.| ||.|:|:||...|||.||.|||..:||.||:|||.|
Human   392 VLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSP 456

  Fly   458 CKLKRKILIKN-KRMKPEVEKVELELWLKGELKTDDDPEEDASAGKPPEAAAAPAPA-------- 513
            ..|..:||:|| ||.:|.....: ....|..|:..:....::||...|.:....:|:
Human   457 QDLMGRILVKNKKRHRPSAGGPD-SAGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLS 520

  Fly   514 -------------PEAAAAAEGAAEGG---GGAEAE-----------------AAAANYSGSTTN 545
                         |:.:...||...|.   |.|:.|                 ......:.|..|
Human   521 NGEEVGLEKPSLEPQKSLGDEGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVN 585

  Fly   546 VHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPK 610
            ....:|::|||.:|:||:.|:.|.::|....||||.|:..|..|.:|.::||.|||:|:||||||
Human   586 ATEEMSTLVNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPK 650

  Fly   611 GTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPF 675
            |||.||||||||:|||.|||:|:||||:.|:.||||.|.|||||..||||||:||||.||.||||
Human   651 GTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPF 715

  Fly   676 ADAPVDGVIAAQCSVKVIAGQFLSDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNED 740
            .:..|||::|....||||:||||||:|||.||||||||||.|| ::::|||....|..|||::|:
Human   716 TEVIVDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDT-RRKYRTRTSQGNSFNPVWDEE 779

  Fly   741 PFVFRKVVLPDLAVLRFGVYEESGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIEL 805
            ||.|.|||||.||.||...:||.||.:|.||||:..:::||.:|.||.|||.|:.||.|.:..|.
Human   780 PFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYTEA 844

  Fly   806 KIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIEEQSGGAARDAGKAKEEEK--------- 861
            ..|:||..:|:...|.:|........|:..|:.|| |.|....|.::..:..:.::
Human   845 SDYIPDDHQDYAEALINPIKHVSLMDQRARQLAAL-IGESEAQAGQETCQDTQSQQLGSQPSSNP 908

  Fly   862 ---------KEPP-----------------------LVFE--PVTLESLRQEKGFQKVGKKQIKE 892
                     :.||                       ::.|  |..|:.||..|...|:..:|.::
Human   909 TPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTPLDELRGHKALVKLRSRQERD 973

  Fly   893 LDTLRKKHAKERTSVQKTQNAAIDKLIKGKSKDDIR-------NDANIKNSI--NDQTKQWTDMI 948
            |..|||||  :|.:|..|:. .:|.|.:.:::...|       ..|:::::.  .|:.|::.:..
Human   974 LRELRKKH--QRKAVTLTRR-LLDGLAQAQAEGRCRLRPGALGGAADVEDTKEGEDEAKRYQEFQ 1035

  Fly   949 ARH-------RKEEWDMLRQ----HVQDSQDAMKALMLTVQAAQIKQLEDRHARDIKDL------ 996
            .|.       |:.:.|...|    |::.:...::.::|.....|.|:|::.:.|:.|:|
Human  1036 NRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQFKRLKEMNEREKKELQKILDR 1100

  Fly   997 ----NAKQAKMSADTAKEVQNDKTLKTKNEKDRRLREKRQNNVKRFMEEKKQ----IGVKQGRAM 1053
                :..:|||.....||.:       ..|.:||...:..|:::|..|.:||    :...|.:.:
Human  1101 KRHNSISEAKMRDKHKKEAE-------LTEINRRHITESVNSIRRLEEAQKQRHDRLVAGQQQVL 1158

  Fly  1054 EKLKLAHSKQIEEFSTDVQK 1073
            ::|.....|.:.:.:.:.|:
Human  1159 QQLAEEEPKLLAQLAQECQE 1178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	39/136 (29%)
		PLN02952	224..786	CDD:178538	286/605 (47%)
		EF-hand_like	227..318	CDD:286375	38/91 (42%)
		PI-PLCc_beta	318..653	CDD:176533	167/377 (44%)
		C2_PLC_like	689..806	CDD:175974	67/116 (58%)
		DUF1154	866..908	CDD:284131	15/43 (35%)
		Mer2	<887..1003	CDD:286200	29/145 (20%)
PLCB3	NP_000923.1	PH_PLC_beta	22..149	CDD:270167	39/136 (29%)
		EF-hand_like	225..315	CDD:286375	37/90 (41%)
		PI-PLCc_beta3	316..693	CDD:176562	167/377 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	467..587		19/120 (16%)
		C2_PLC_like	728..843	CDD:175974	66/115 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	887..937		3/49 (6%)
		DUF1154	951..988	CDD:284131	15/38 (39%)
		BAR	<1023..1146	CDD:299863	26/129 (20%)
		PLC-beta_C	1029..1202	CDD:285865	30/157 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1198..1234
		Interaction with SHANK2. /evidence=ECO:0000250	1231..1234
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102409
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750