DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment norpA and PLCB2

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	XP_024305716.1	Gene:	PLCB2 / 5330	HGNCID:	9055	Length:	1208	Species:	Homo sapiens

Alignment Length:	1170	Identity:	410/1170 - (35%)
Similarity:	605/1170 - (51%)	Gaps:	165/1170 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VPPE----LTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDI 73
            :||:    |:.|..|.:|.:      |.......:.:||..|::|||..:.::.:.:::..:.|.
Human     9 LPPKVKAYLSQGERFIKWDD------ETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDT 67

  Fly    74 RAGGTPKDPKILDKVTKKNGTNIPELD--KRSLTICSNTDYINITYHHVICPDAATAKIWLDGIR 136
            |.|...|.|| ..|:......:.|:..  .::||:.|..|.:::|:|:.:.......|.|.:.:.
Human    68 RFGKFAKMPK-SQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDVL 131

  Fly   137 KITHNVKANNICPMMCLRKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDAGLPDDK 201
            .:..:....|......|.|..::|...:...||||||...:.|.:.:  |.|...:....||..|
Human   132 ALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADR--KRVEAALSACHLPKGK 194

  Fly   202 NATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILY 266
            |..:..|.|....:.:....:|||.:|:|:|||.....:.:::.|...:|:|.||||.|:|.:|:
Human   195 NDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLF 259

  Fly   267 PLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYIN 331
            |.....:...:|:.||......:..|:|.:|...:|...||:.:..|:|..:.:|.|||.||:||
Human   260 PPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFIN 324

  Fly   332 SSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQ 396
            |||||||:..|..|.||.|||||.||:||||||||||.||..|||||:|||....|:|.||:.|:
Human   325 SSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIE 389

  Fly   397 AIADCAFVSSEYPVILSFENHCNR-AQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKL 460
            |||:.||.:|.||:|||||||.:. .||.|:|:||...|||:||.|||...||.||:|||.|..|
Human   390 AIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDL 454

  Fly   461 KRKILIKNKRMKPEVEKVELELWLKGELKTDDDPEEDASAGKPPEAAAAPAPAPEAAAAAEGA-- 523
            :.|||||||:.:           ..|...:..|...:|....||   :|||......|..||.
Human   455 RGKILIKNKKNQ-----------FSGPTSSSKDTGGEAEGSSPP---SAPAGEGTVWAGEEGTEL 505

  Fly   524 ---------AEGGGGAEAEAAAANYS-----GSTTNVHPWLSSMVNYAQPIKFQGFDKAI----- 569
                     .|..|..:.|......|     |.....:..:||:|||.||.||..|:.:.
Human   506 EEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAPRLFT 570

  Fly   570 --------EKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWN 626
                    :||.::.:|||.|....:.|.::|:.||:|||||||||||||||.||||||||:|||
Human   571 CIFSGHKHKKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWN 635

  Fly   627 AGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVK 691
            ||||||:||||:.|||||.|...||:||..|||||.:||||.||.|:||:...:|.|:|...|:.
Human   636 AGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSIT 700

  Fly   692 VIAGQFLSDKKVGTYVEVDMFGLPSDTVKKEFRTRL-VANNGLNPVYNEDPFVFRKVVLPDLAVL 755
            ||:|||||::.|.|||||::||||.|. |:.:||:| .:.|.:|||:.|:||||.|:::|:||.|
Human   701 VISGQFLSERSVRTYVEVELFGLPGDP-KRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASL 764

  Fly   756 RFGVYEESGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIELKIYVPDGFEDFMAML 820
            |..|.||..|.||.||:|::.|.:||.|:.|.:|:|.|:::|.||:.:|:|.|:|..:.|....|
Human   765 RVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVAL 829

  Fly   821 SDPRGFAGAAKQQNEQMK-ALG------------IEEQSGGA---------ARDAGKAKEEEKKE 863
            ::|..|..|...::.::| |:|            :..|..||         |..|| |:||..||
Human   830 ANPIKFFSAHDTKSVKLKEAMGGLPEKPFPLASPVASQVNGALAPTSNGSPAARAG-AREEAMKE 893

  Fly   864 PPLVFEPVT--LESLRQEKGFQKVGKKQIKELDTLRKKHAK------ERTSVQKTQ-------NA 913
               ..||.|  ||.||:.||..|:.::..|||..|.::.|:      :|.:.|..:       ..
Human   894 ---AAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGV 955

  Fly   914 AIDKLIKGKSKDDIRNDANIKNS----------INDQTKQWTDM----IARHRKEEWDML----R 960
            ...||..||.....|:....:::          ::.:.::..|.    :.|..:|:::.:    .
Human   956 GACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKE 1020

  Fly   961 QHVQDSQDAMKALMLTVQAAQIKQLED---------------------------------RHARD 992
            |||.:....|..|....|||::|.|::                                 ||.||
Human  1021 QHVAEQISKMMELAREKQAAELKALKETSEKYDCLPPTPASPPSKGSAAQNSSFMPVSLQRHQRD 1085

  Fly   993 IKDLNAKQ--AKMSADTAKEVQNDKTLKTKNEKDRRLREKRQNNVKRFMEEKKQIGVKQGRAMEK 1055
            .:....|:  |....|.:...|:.....|:|.:  |.:||        :|||:...::|.|.|||
Human  1086 EEKAGDKETGADPGHDQSHHRQDGPGEMTENLE--RHQEK--------LEEKQAACLEQIREMEK 1140

Fly 1056 1055
Human 1141 1140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	28/133 (21%)
		PLN02952	224..786	CDD:178538	275/592 (46%)
		EF-hand_like	227..318	CDD:286375	27/90 (30%)
		PI-PLCc_beta	318..653	CDD:176533	176/364 (48%)
		C2_PLC_like	689..806	CDD:175974	59/117 (50%)
		DUF1154	866..908	CDD:284131	16/49 (33%)
		Mer2	<887..1003	CDD:286200	31/181 (17%)
PLCB2	XP_024305716.1	PH_PLC_beta	17..144	CDD:270167	28/133 (21%)
		EFh_PI-PLCbeta2	149..299	CDD:320039	43/151 (28%)
		EF-hand motif	149..178	CDD:320039	9/28 (32%)
		EF-hand motif	182..211	CDD:320039	6/28 (21%)
		EF-hand motif	220..249	CDD:320039	8/28 (29%)
		EF-hand motif	266..299	CDD:320039	7/32 (22%)
		PI-PLCc_beta2	311..662	CDD:176561	176/364 (48%)
		C2_PLC_like	694..815	CDD:175974	60/121 (50%)
		PLC-beta_C	991..1176	CDD:312287	34/160 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102409
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720