DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment norpA and PLCE1

DIOPT Version :9

Sequence 1:NP_001014720.1 Gene:norpA / 31376 FlyBaseID:FBgn0262738 Length:1095 Species:Drosophila melanogaster
Sequence 2:XP_006717948.1 Gene:PLCE1 / 51196 HGNCID:17175 Length:2316 Species:Homo sapiens


Alignment Length:1277 Identity:307/1277 - (24%)
Similarity:483/1277 - (37%) Gaps:407/1277 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 GRDGDVIELCQVSDIRAGGTPKDPKILDKVTKKNGTNIPELDKRSLTICSNTDYINITYHHVICP 123
            |.|...|...:.|::.|...|.:|             :|.....|||...:.             
Human  1120 GSDPQDINEQEESEVNAIANPPNP-------------LPSRRAHSLTTAGSP------------- 1158

  Fly   124 DAATAKIWLDGIRKITHNVKANNICPMMCLRKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLV 188
                             |:.|....|:..:.      |..:..|.|.|....:.:...|:.:   
Human  1159 -----------------NLAAGTSSPIRPVS------SPVLSSSNKSPSSAWSSSSWHGRIK--- 1197

  Fly   189 YTCIKDAGLPDDKNATMTKEQFTFDKFYALY--HKVCPRNDIEELF------------------- 232
                  .|:...::..::....:|.:|..|:  ..|..|.|:::||                   
Human  1198 ------GGMKGFQSFMVSDSNMSFVEFVELFKSFSVRSRKDLKDLFDVYAVPCNRSGSESAPLYT 1256

  Fly   233 -------TSITKGKQDFIS-----LEQFI---QFMNDKQRD------------------------ 258
                   ||..:...|.::     |..||   |.::|.||.                        
Human  1257 NLTIDENTSDLQPDLDLLTRNVSDLGLFIKSKQQLSDNQRQISDAIAAASIVTNGTGIESTSLGI 1321

  Fly   259 -----PRMNEILYPLYEEKRCT-----EIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLD 313
                 .::|:.|.....| .||     .||..:|..........||.:||.|:||..||   |..
Human  1322 FGVGILQLNDFLVNCQGE-HCTYDEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKEN---FAS 1382

  Fly   314 RLD----FYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGED 374
            :.|    ...|:..||::|||.|||||||:|.|:.|:||||:|.|.||.|||.||||||:  |:|
Human  1383 KNDESQENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWD--GDD 1445

  Fly   375 EEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLL 439
            ..||:.|||...|:|.||:.::||...||::|:.|:|:|.||||:..||.|:|:.....||:.|:
Human  1446 GMPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTVFGEKLV 1510

  Fly   440 KEPL--PDHPLDPGLPLPPPCKLKRKILIKNKRMKPEVEKVELELWLK----------------- 485
            .:.|  .|...||  .||.|.:|::|:|:|||::|.....|::   ||                 
Human  1511 TKFLFETDFSDDP--MLPSPDQLRKKVLLKNKKLKAHQTPVDI---LKQKAHQLASMQVQAYNGG 1570

  Fly   486 --------GELKTDDDPEED---ASAGKPPEAAAAPAP----------APEAAA----------- 518
                    .|.:.|::.|.|   .|........|:|||          .||..:           
Human  1571 NANPRPANNEEEEDEEDEYDYDYESLSDADVLTASPAPNGQEDNILEDRPENKSCNDKLQFEYNE 1635

  Fly   519 --------AAEGAAEGGGGAEAEAAAANY----SGSTTNVHPWLSSMVNYAQPIKFQG------- 564
                    |...|...|...:.|.....|    ...:..:.|.||.:|.|.|.:||.|       
Human  1636 EIPKRIKKADNSACNKGKVYDMELGEEFYLDQNKKESRQIAPELSDLVIYCQAVKFPGLSTLNAS 1700

  Fly   565 -----------------------------FDKAIEKNI--------------------------- 573
                                         |:|...|:.                           
Human  1701 GSSRGKERKSRKSIFGNNPGRMSPGETASFNKTSGKSSCEGIRQTWEESSSPLNPTTSLSAIIRT 1765

  Fly   574 --AHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNF 636
              .:::||..|:|.....::.|.....:...|:.|.||..||.||||..|.:||..|.|:|:||:
Human  1766 PKCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLVALNY 1830

  Fly   637 QSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKD------FDPFADAPVDGVIAAQCSVKVIAG 695
            |:.|||:.||...||.||||||:|||..:  .||:      |.|. :..:|.:..|..|:.:::|
Human  1831 QTDDLPLHLNAAMFEANGGCGYVLKPPVL--WDKNCPMYQKFSPL-ERDLDSMDPAVYSLTIVSG 1892

  Fly   696 QFL--SDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRKVVLPDLAVLRFG 758
            |.:  |:......:|||:.|:|.|:.  .|||:.:..|.|||::||. |:|. |...||..|||.
Human  1893 QNVCPSNSMGSPCIEVDVLGMPLDSC--HFRTKPIHRNTLNPMWNEQ-FLFH-VHFEDLVFLRFA 1953

  Fly   759 VYE-ESGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNI------------------- 803
            |.| .|..:..|||:||..|:.||||:.||...|..:.:..||:|.                   
Human  1954 VVENNSSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLFINSRRMEENSSGNTMSASSMFN 2018

  Fly   804 ----------ELKIYVPDGFEDFMA------------------------------MLSDPRGFAG 828
                      .:.::...|.|.|..                              .|.:.:.|  
Human  2019 TEERKCLQTHRVTVHGVPGPEPFTVFTINGGTKAKQLLQQILTNEQDIKPVTTDYFLMEEKYF-- 2081

  Fly   829 AAKQQNEQMK-----ALGIEE-----------QSGGAARDAGKAKEEEKKEPPLVFEPVTLESLR 877
            .:|::||..|     |:|.||           :.|...|...|.::|..:|..:|.:...:....
Human  2082 ISKEKNECRKQPFQRAIGPEEEIMQILSSWFPEEGYMGRIVLKTQQENLEEKNIVQDDKEVILSS 2146

  Fly   878 QEKGFQKVGKKQIKELDTLRKKHAKERTSVQKTQNAAIDKLIKGKSKDDIRNDAN------IKNS 936
            :|:.|    ..|:.::...:.:...:...|...|:.....|.|.|....|.::.|      ::..
Human  2147 EEESF----FVQVHDVSPEQPRTVIKAPRVSTAQDVIQQTLCKAKYSYSILSNPNPSDYVLLEEV 2207

  Fly   937 INDQT-KQWTDMIARHR-----------KEEWD-------MLRQHVQDS-QDAMKALMLTVQAAQ 981
            :.|.| |:.|...:..|           :.:|.       .|::.||.| :|..|.:..   |::
Human  2208 VKDTTNKKTTTPKSSQRVLLDQECVFQAQSKWKGAGKFILKLKEQVQASREDKKKGISF---ASE 2269

  Fly   982 IKQLEDRHARDIKDLNAKQAKMSADTAKEVQNDKTLKTKNEK 1023
            :|:|..         :.||.: ...:..::...::::||.||
Human  2270 LKKLTK---------STKQPR-GLTSPSQLLTSESIQTKEEK 2301

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
norpANP_001014720.1 PH_PLC_beta 17..149 CDD:270167 13/89 (15%)
PLN02952 224..786 CDD:178538 227/770 (29%)
EF-hand_like 227..318 CDD:286375 32/162 (20%)
PI-PLCc_beta 318..653 CDD:176533 139/462 (30%)
C2_PLC_like 689..806 CDD:175974 46/148 (31%)
DUF1154 866..908 CDD:284131 4/41 (10%)
Mer2 <887..1003 CDD:286200 25/141 (18%)
PLCE1XP_006717948.1 RasGEF 539..713 CDD:279011
PLN02952 1318..1997 CDD:178538 217/696 (31%)
EF-hand_like <1328..1379 CDD:286375 15/51 (29%)
PI-PLCc_epsilon 1391..1847 CDD:176538 139/462 (30%)
C2_PLC_like 1886..1998 CDD:175974 45/115 (39%)
UBQ 2151..2250 CDD:294102 15/102 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.