DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment norpA and Plcz1

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	NP_001012234.1	Gene:	Plcz1 / 497197	RGDID:	1359567	Length:	645	Species:	Rattus norvegicus

Alignment Length:	664	Identity:	227/664 - (34%)
Similarity:	341/664 - (51%)	Gaps:	71/664 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 KSGKIPVKTLAKTFASGKTEKLVYTC----IKDAGLPDDKNATMTKEQFTFDKFYALYHKVCPRN 226
            :.|||......|..     |||.:.|    :|.....:|::   .:.:.|.:.|..:|..:..|.
  Rat    22 RGGKISAGITHKLL-----EKLDFPCHFAHVKRIFKENDRH---NQGRITTEDFRTIYRCIVHRE 78

  Fly   227 DIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPLYEEKRCTEIINDYELDEEKKKNV 291
            :|.|:|.:.|:.:: .:..:..|:|:..:|.:..|        :|....|||..||...|.|...
  Rat    79 EIVEIFNTYTENRK-ILPEDSLIEFLTQEQYEMEM--------DESSSVEIIQKYEPIAEVKNER 134

  Fly   292 QMSLDGFKRYLMSDENAPVFLDRLD-FYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQT 355
            |||::||.||:.|.| ..:|.:..: .|.:|::||..|||:|||||||...||.|.|.:..|...
  Rat   135 QMSIEGFARYMFSSE-CLLFKETCNTVYQDMNKPLNDYYISSSHNTYLISDQILGPSDIWGYISA 198

  Fly   356 LLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNR 420
            |:.||||:|:|||:  |...||||.||:...:::|||..||||...|||:|:|||:||.||||:.
  Rat   199 LVKGCRCLEIDCWD--GAQNEPIVYHGYTLTSKLLFKTVIQAINKYAFVTSDYPVVLSLENHCSP 261

  Fly   421 AQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRKILIKNK--------RMKPEVEK 477
            .||..:.......|||.||.:.|.:.|..    ||.|..||.|||:|||        |.:...:|
  Rat   262 GQQEVMTDILQSTFGDFLLSDILDEFPDS----LPSPEALKFKILVKNKKVGTLSETRERLGTDK 322

  Fly   478 VELELWLKGELKTDDDPEEDASAGKPPEAAAAPAPAPEAAAAAEGAAEGGGGAEAEAAAANYSGS 542
            ..:.|.|:.|:..:    ||..:||.||.      ..:..:..:...|......:..|.|.....
  Rat   323 RGIALDLEEEIYEN----EDEDSGKEPET------WDDFLSRVKEEQEADPSTLSGIADAKKKIR 377

  Fly   543 TTNVHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRI 607
            ...|...||.:|.|.:..||:.|..:......:..:|..||......|..:.:|:.:....::|:
  Rat   378 KLRVALALSDLVIYTKAEKFRNFQYSRVYQQFNETTSMGESRARKLSKLRAHEFIFHTAAFITRV 442

  Fly   608 YPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDF 672
            |||.|||||||:.||.|||.|||||:||||:..|||.|..|||..|||.||:|||||:|.....|
  Rat   443 YPKFTRADSSNFNPQEFWNVGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYVLKPDFLRDTTLGF 507

  Fly   673 DPFADAPVDGVIAAQCSVKVIAGQFL--------SDKKVGTYVEVDMFGLPSDTVKKEFRTRLVA 729
            :|  :.|.........::::|:|..|        ||    ..|.::::|:|:|.:|::  :|.|.
  Rat   508 NP--NEPEGDGHPVTLTIRLISGIQLPVNVPSNTSD----IIVIIEVYGVPNDHMKQQ--SRAVK 564

  Fly   730 NNGLNPVYNEDPFVFRKVVLPDLAVLRFGVYEESG-----KILGQRILPLDGLQAGYRHVSLRTE 789
            ||..:|.:|| .|.| .:.:|:||::|| |.|..|     ::|||..||:..:..|||.|.|.::
  Rat   565 NNAFSPRWNE-TFTF-LIQVPELALIRF-VVETQGFLSGNELLGQYTLPVLCMNKGYRRVPLFSK 626

  Fly   790 ANFPMSLPMLFVNI 803
            :...:....||:.:
  Rat   627 SGANLEPSSLFIYV 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167
		PLN02952	224..786	CDD:178538	211/583 (36%)
		EF-hand_like	227..318	CDD:286375	26/91 (29%)
		PI-PLCc_beta	318..653	CDD:176533	134/342 (39%)
		C2_PLC_like	689..806	CDD:175974	39/128 (30%)
		DUF1154	866..908	CDD:284131
		Mer2	<887..1003	CDD:286200
Plcz1	NP_001012234.1	PLN02952	78..640	CDD:178538	213/598 (36%)
		EF-hand_like	79..161	CDD:286375	26/91 (29%)
		PI-PLCc_GDPD_SF	161..488	CDD:301322	134/342 (39%)
		C2_PLC_like	518..643	CDD:175974	39/132 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820