DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment norpA and plcd1b

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	XP_005163413.1	Gene:	plcd1b / 337489	ZFINID:	ZDB-GENE-030131-9435	Length:	772	Species:	Danio rerio

Alignment Length:	829	Identity:	261/829 - (31%)
Similarity:	387/829 - (46%)	Gaps:	171/829 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIRAGGTPKDPKILDKVTKK--NGT 94
            :.:...:::...||:.| .....|....:.....:...:.||....|.:....|.|.|::  .|.
Zfish    52 KVRSESWKKTRYFKLQE-DCKTMWHESKKTLKTKQTFSIEDIEEVRTGRQTDSLRKYTEETLEGR 115

  Fly    95 NIPELDK---RSLTICSNTDYINITYHHVICPDAATAKIWLDGIRKITHNVKANNICPMMCLRKH 156
            ....|.|   :||.:.::|:              ..||.|:.|:.|:..::  ||:.
Zfish   116 AFSILFKGRQKSLDLIASTE--------------EEAKKWVSGLEKVISSL--NNLS-------- 156

  Fly   157 WMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDAGLPDDK---NATMTKEQFTF------ 212
                                   :..|||..:|:.::.|    ||   |....||..:|
Zfish   157 -----------------------SQKKTEHWIYSSLRKA----DKNLDNKMSLKEVKSFLKDINV 194

  Fly   213 ---DKFYALYHKVCPR--------NDIEELFTSITK-----------GKQD-FISLEQFIQFMND 254
               :.:..:..|.|.:        |:||..:..:||           .|.| .:|....:.|:..
Zfish   195 EVHEDYAEMLFKECDKSNGGFLEGNEIEHFYKILTKREEIDVIYGEYAKTDGLMSANDLLNFLLT 259

  Fly   255 KQRDP-RMNEILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFY 318
            :||:. ..|:.|          ::|..|||||..|...||:.|||..||...|...........|
Zfish   260 EQREEVSQNDAL----------QLIEKYELDENAKAKQQMTQDGFLMYLHQPEGLIFNQAHKSVY 314

  Fly   319 MEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGH 383
            .:|:|||:||:|:|||||||...|:.|.||.|.|.:.||.||||||||||:  |.|.||::.||:
Zfish   315 HDMNQPLSHYFISSSHNTYLMEDQLKGPSSTEAYIRALLKGCRCVELDCWD--GSDGEPVIYHGY 377

  Fly   384 AYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPL 448
            ...::|||||.|:||.:.||.:||||||||.||||...||..:|::.....|..|:.:||.|.
Zfish   378 TLTSKILFKDVIKAIKEYAFKTSEYPVILSLENHCGVEQQKIMAQHLTSILGSALVTKPLGDQ-- 440

  Fly   449 DPGLP--LPPPCKLKRKILIKNKRMKPEVEKVELELWLKGELKTDDD----PEEDASAGKPPEAA 507
               :|  ||.|.:||.:.::|.||:.      :||.....|.|..|:    .|||
Zfish   441 ---MPTCLPAPEELKGRFIVKGKRLD------KLENAFSDESKMADEESVSEEED---------- 486

  Fly   508 AAPAPAPEAAAAAEGAAEGGGGAEAEAAAANYSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEKN 572
                        .||..|..         ...||| ..:...||.:|.|.:.:.|.|.:.:.||:
Zfish   487 ------------DEGDEENN---------EKKSGS-LKLAKELSDIVIYCKSVPFHGLEDSREKH 529

  Fly   573 IAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQ 637
            ..:.|:||.|...:...::|:.:::.:|..::|||||.|.|.|||||.|...||||||:|:||||
Zfish   530 SFYEMASFKEGKALKLAEESATEYIRHNTDKLSRIYPGGMRTDSSNYNPVPMWNAGCQIVALNFQ 594

  Fly   638 SSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQFLSDKK 702
            :..|.|.||||.|..||..||:|||.::|..|.:|||........:......|.||:.|.|  .|
Zfish   595 TPCLEMDLNQGLFYQNGRSGYILKPSYLRERDTEFDPITLTKGPWLKRKTLHVMVISAQQL--PK 657

  Fly   703 VG--------TYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFR-KVVLPDLAVLRFG 758
            ||        ..|:|.::|:|:||...|  |..:.|||.||::||:   |: :|.:||||::||.
Zfish   658 VGKRESAIVDPIVKVQVYGVPADTAAVE--TSYIKNNGFNPMWNEN---FQLEVCVPDLALVRFL 717

  Fly   759 V--YEES--GKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNI 803
            :  |:.:  .:.:||..||.:.|:.||.||.|.|:....:|...|||:|
Zfish   718 IEDYDSTSDNEFIGQYTLPFNSLRNGYHHVPLLTQDGNLLSSAGLFVHI 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	23/121 (19%)
		PLN02952	224..786	CDD:178538	218/601 (36%)
		EF-hand_like	227..318	CDD:286375	27/103 (26%)
		PI-PLCc_beta	318..653	CDD:176533	137/340 (40%)
		C2_PLC_like	689..806	CDD:175974	48/128 (38%)
		DUF1154	866..908	CDD:284131
		Mer2	<887..1003	CDD:286200
plcd1b	XP_005163413.1	PH_PLC_delta	44..159	CDD:270169	23/154 (15%)
		PH	48..150	CDD:278594	21/112 (19%)
		EF-hand_10	179..228	CDD:291454	8/48 (17%)
		PLN02228	232..764	CDD:177873	217/593 (37%)
		EF-hand_like	233..314	CDD:286375	23/90 (26%)
		PI-PLCc_delta1	314..610	CDD:176566	137/340 (40%)
		C2_PLC_like	643..768	CDD:175974	48/131 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820