Protein Alignment norpA and sl

DIOPT Version :10

• Sequence 1: NP_525069.2
• Gene: norpA / 31376
• FlyBaseID: FBgn0262738
• Length: 1095
• Species: Drosophila melanogaster
• Sequence 2: NP_476726.2
• Gene: sl / 32601
• FlyBaseID: FBgn0003416
• Length: 1236
• Species: Drosophila melanogaster
• Alignment Length: 1245
• Identity: 272/1245 - (21%)
• Similarity: 403/1245 - (32%)
• Gaps: 533/1245 - (42%)

  Fly    26 WFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIRAGGTPKDPKILDKVTK 90
            |.....:|...|:|                       ..|:|.::.:||.|...|:.::.
  Fly    54 WATVATQTPRTDYE-----------------------GAIQLREIREIRVGKHSKEFRLF----- 90

  Fly    91 KNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKSWQKNLRLITHNNRATNVCPRVNLMK 155
              ..:....:.....:..:.::..:....|:......|.:|.:.||.:.   :.|...|....:.
  Fly    91 --ADDCQRFESSKCFVILHGNHFKLKSFSVVALSEIEADNWVRGLRYMV---KDTLGAPYPLQID 150

  Fly   156 HWMRLSY------------CVEKS-GKIPVKTLAKTFASGKTEKLVYTCIKDAGLPDDKNATMTK 207
            .|:|..|            ..|:| .::.:|.. |.|.:|.:.|:......:....|.:.    |
  Fly   151 RWLRREYYQIENVNTHSAKATEQSPAQVTIKDF-KLFLAGVSCKMTTGKFMEHFTEDVRR----K 210

  Fly   208 EQFTFDKFYALYHKVCPRNDIEELFTSITKGK----------QDFISLEQFIQFMNDKQRDPRMN 262
            ....||.|..||.|:...|.    |.|:..|.          |..:...:..||:..:|||...:
  Fly   211 HDLKFDDFSRLYQKLLLPNG----FASVLSGSGVANFPYSEDQQVVRPAELKQFLETEQRDVSAS 271

  Fly   263 EILYPLYEEKRCTEIINDYELDEEKKKNVQ---MSLDGFKRYLMSDENAPVFLDRLD-FYMEMDQ 323
            ||     ........|.|:..|.|  ::||   ::...|..:|.|.:| .::..:.| .:|:|:.
  Fly   272 EI-----SSAAIASFIRDFVQDVE--RDVQEPYLTFPEFVDFLFSKQN-DLWNSKYDQVFMDMNL 328

  Fly   324 PLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTE 388
            ||:.|:|.|||||||:|.|...:||.|.|.:.|..||||:||||||  |.|..|.:.|||...::
  Fly   329 PLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWN--GPDNLPYIFHGHTITSK 391

  Fly   389 ILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPL---PDHPLDP 450
            |.|.|.|:.|.|.||.|||||||||.|.:|:..||..:|:...:.|||:||.:|.   ..|
  Fly   392 IKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGDMLLTQPCDRNEQH---- 452

  Fly   451 GLPLPPPCKLKRKILIKNKRM-------------------------------------------- 471
               ||.|.:|:|||::|:|::
  Fly   453 ---LPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKVFKE 514

  Fly   472 -----KPEVEK---------VELELWLKGEL-------KTDDD---------------PEEDASA 500
                 |..|:|         ...||....|:       ..|||               .::|.||
  Fly   515 GLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKDTSA 579

  Fly   501 ----------------GKPPEA------------------------------------------- 506
                            |...||
  Fly   580 NDELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRIK 644

  Fly   507 -----------------------------------------AAAPAPAPE--------------- 515
                                                     ...|.|.|:
  Fly   645 LKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQEWFHPNTTKE 709

  Fly   516 ----------------------------------------------------------------- 515
                                                                             
  Fly   710 QAEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNFESLVSLINYY 774

  Fly   516 --------------------AAAAAEGAAEGGGGAEAEAAAANYSGST----------------- 543
                                ..|.||.|.....|...:..|:||.||.
  Fly   775 TRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTCKALYSYKANK 839

  Fly   544 ------------TNVHP-----WLSSM---------VNYAQPI---------------------- 560
                        |||..     |:...         .||.:.|
  Fly   840 PDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYNSLNEEGTDGRTDSI 904

  Fly   561 -------------------KFQ------------GFD---------KAIEKN------------- 572
                               |.|            |||         |||::.
  Fly   905 EIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQEAALIASQLASERRK 969

  Fly   573 ----------------------------IAHNMSSFAES-AGMNYLKQSSIDFVNYNKRQMSRIY 608
                                        |...||||.|: |...:.:|::..|::|::.|:||:|
  Fly   970 KERTARVAKEMSDLIIYFRSVPFREHSWIFQEMSSFPETKAEKQFFQQNTQLFLSYHRNQISRVY 1034

  Fly   609 PKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFD 673
            |||.|.||||:.|..|||.|.||::||:|:.|..|||||.||..||.|||:|||.||:  ...|:
  Fly  1035 PKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMK--SDSFN 1097

  Fly   674 PFADAPV-DGVIAAQCSVKVIAGQ--FLSDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNP 735
            |  :.|: ||:...:.|:::||.:  |...|.....:.|::.|...||..| :||: |..||.||
  Fly  1098 P--NNPLCDGLSEVKVSIRLIAARHLFRGGKSNNPQIVVELIGASFDTGVK-YRTK-VNENGFNP 1158

  Fly   736 VYNED-PFVFRKVVLPDLAVLRFGVYEE----SGKILGQRILPLDGLQAGYRHVSLRTEANFPMS 795
            |:||. .|..|.   |..|:|||.|.:|    ....:.|...||..::.|||.|.||.:.:..:.
  Fly  1159 VWNESCEFNVRN---PQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYRSVILRNKFSEELE 1220

  Fly   796 LPMLFVNIEL 805
            |..|.:||::
  Fly  1221 LSSLLINIKI 1230

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_525069.2	PH_PLC_beta	17..149	CDD:270167	16/122 (13%)
		EFh_NorpA_like	154..306	CDD:320042	39/177 (22%)
		EF-hand motif	154..183	CDD:320042	8/41 (20%)
		EF-hand motif	189..218	CDD:320042	5/28 (18%)
		EF-hand motif	227..256	CDD:320042	6/38 (16%)
		EF-hand motif	273..306	CDD:320042	9/35 (26%)
		PI-PLCc_beta	318..653	CDD:176533	157/764 (21%)
		C2_PLC_like	689..806	CDD:175974	42/124 (34%)
		DUF1154	865..909	CDD:461969
		PLC-beta_C	952..1073	CDD:462571
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168	17/125 (14%)
		EFh_PI-PLCgamma	152..311	CDD:320031	39/174 (22%)
		EF-hand motif	152..191	CDD:320031	9/39 (23%)
		EF-hand motif	198..226	CDD:320031	8/31 (26%)
		EF-hand motif	230..265	CDD:320031	6/38 (16%)
		EF-hand motif	277..311	CDD:320031	9/35 (26%)
		PI-PLCc_gamma	323..>470	CDD:176534	74/155 (48%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	3/97 (3%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	0/99 (0%)
		SH3_PLCgamma	828..880	CDD:212759	6/51 (12%)
		PLCYc	981..1091	CDD:128454	48/109 (44%)
		C2_PLC_like	1109..1215	CDD:175974	38/110 (35%)