DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment norpA and Plch2

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	XP_008762618.2	Gene:	Plch2 / 313756	RGDID:	1304675	Length:	1570	Species:	Rattus norvegicus

Alignment Length:	996	Identity:	271/996 - (27%)
Similarity:	423/996 - (42%)	Gaps:	247/996 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIRAGGTPKDPKILDKVT 89
            ||    :.:::|:..:.::..:.|.       ||||..::.:       |...:..||.....:
  Rat   222 RW----RPSRKNEKAKISIDSIQEV-------SEGRQSEIFQ-------RYPDSSFDPNCCFSI- 267

  Fly    90 KKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKIWLDGIRKITHNVK-ANNICPMMCL 153
             ..|::...||                   ::.|.:..|:.|:.|:|.:...:. .:::......
  Rat   268 -YYGSHRESLD-------------------LVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRT 312

  Fly   154 RKHWMRLSYC-VEKSG------------------KIPVKTLAKTFASGKTEKLVYTCIKDAGLPD 199
            |..|::.::. .:|:|                  .:|.:.:.:.|....|              |
  Rat   313 RDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADT--------------D 363

  Fly   200 DKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQ--DFISLEQFIQFMNDKQRDPRMN 262
            |...|:     .|::|.|.|..:..|.|:..|..:.:..|.  |...|::|::.      :.:|:
  Rat   364 DHQGTL-----GFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEV------EQKMS 417

  Fly   263 EILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAH 327
            .:..     :.|..||..:|...|.|....:.:|||..|..|........:....:.:|.|||:|
  Rat   418 GVTL-----ESCQSIIEQFEPCLENKSKGVLGIDGFTNYTRSPAGDIFNPEHHRVHQDMTQPLSH 477

  Fly   328 YYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFK 392
            |:|.|||||||.|.|:..:|.|:||...|.|||||||:|||:  |.|.||||.||:...::||||
  Rat   478 YFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWD--GPDGEPIVHHGYTLTSKILFK 540

  Fly   393 DCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPP 457
            |.|:.|...||:.:|||||||.||||:..||.|:|:|..|..||   |..|.....:....||.|
  Rat   541 DVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGD---KLDLSSVSGEDATMLPSP 602

  Fly   458 CKLKRKILIKNKRMKPEV-EKVELELWLKGELKTDDDPEE----------DASAGK--------- 502
            ..||.|||:|.|::...: |..|     :||:..:|..:|          |||..:
  Rat   603 QMLKGKILVKGKKLPANISEDAE-----EGEVSDEDSADEIEDDCKLLNGDASTNRKRVENIAKK 662

  Fly   503 --------------------------PPEAAAAPAPAPEAAAAAEGAAEGG-------------- 527
                                      |.......|.|.:|.:.||...|.|
  Rat   663 KLDSLIKESKIRDCEDPNDFTVSTLSPSGKLGHKAEAKKAQSKAEEDVESGEDTGVSRRNSRLLM 727

  Fly   528 --------GGAEAEAAAANYSG------------------STTNVHPWLSSMVNYAQPIKFQGFD 566
                    .|::.:..|:...|                  .|..:...||.:|.|.:.:...  |
  Rat   728 SSFSKRKKKGSKIKKVASVEEGDESLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTH--D 790

  Fly   567 KAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQM 631
            ..:|...:..:|||:|:.....|:|....::.:|:.|:|||||...|.|||||.||.||||||||
  Rat   791 VEMEVVSSWQVSSFSETKAHQILQQKPAQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQM 855

  Fly   632 VSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQ 696
            |:||:||....:|||:.||..||||||:|||..|  ....|:|.::.|:.|.:..|.::::|:||
  Rat   856 VALNYQSEGRMLQLNRAKFSANGGCGYVLKPQCM--CQGVFNPNSEDPLPGQLKKQLALRIISGQ 918

  Fly   697 FLSDKK----------VGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRKVVLPD 751
            .|...:          :..:|||::.|||.|..|::  ||:|.:||.||:: |:..|| .|.:|:
  Rat   919 QLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQ--TRVVDDNGFNPMW-EETLVF-TVHMPE 979

  Fly   752 LAVLRFGVYEES--GK-ILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIEL-----KIY 808
            :|::||.|::..  |: .:|||.|....:..|||||.|.     .|....:||::.:     |:.
  Rat   980 IALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLE-----GMEEASIFVHVAVSDISGKVK 1039

  Fly   809 VPDGFEDFMAMLSDP-----------------------RGFAGAAKQQNEQMK-----ALGIEEQ 845
            ...|.:........|                       |..:...|.|....|     |||.::.
  Rat  1040 QTLGLKGLFLRGPKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDA 1104

  Fly   846 -SGGAARDAGKAKEEEKKEPP 865
             |.|||.|..........|.|
  Rat  1105 GSEGAADDVAPPSPNPALEAP 1125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	19/124 (15%)
		PLN02952	224..786	CDD:178538	217/662 (33%)
		EF-hand_like	227..318	CDD:286375	18/92 (20%)
		PI-PLCc_beta	318..653	CDD:176533	145/420 (35%)
		C2_PLC_like	689..806	CDD:175974	42/134 (31%)
		DUF1154	866..908	CDD:284131	271/996 (27%)
		Mer2	<887..1003	CDD:286200
Plch2	XP_008762618.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920