DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment norpA and Plcg2

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	NP_058864.1	Gene:	Plcg2 / 29337	RGDID:	3348	Length:	1265	Species:	Rattus norvegicus

Alignment Length:	1270	Identity:	285/1270 - (22%)
Similarity:	446/1270 - (35%)	Gaps:	506/1270 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 KSEGRDGDVIELCQVSDIRAGGTPKDPKILDKVTKKNGTNIPELDKRSLTICSNTDYINITYHHV 120
            |.||    .:::.::.:||.|...||.:....|..|...        ..||...|.::..|..
  Rat    60 KIEG----FLDIMEIKEIRPGKNSKDFERAKAVRHKADC--------CFTIFYGTQFVLSTLS-- 110

  Fly   121 ICPDAATAKI-WLDGIRKITHNVKANNICPMMCLRKHWMRLS-YCVEKS--GKIPVKTLAKTFAS 181
            :..|:....: ||.|: ||.|....|...|.|.  :.|:|.. |.|:::  ..|.::.| ||.
  Rat   111 LATDSKEDAVKWLSGL-KILHQEAMNASTPTMI--ESWLRKQIYSVDQTRRNSISLREL-KTI-- 169

  Fly   182 GKTEKLVYTCIKDAGLPDDKNATM----TKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQD- 241
                 |.....|.:|:...|:..:    .|::.:|::|:..|.|:.    .|:..:.:.:.|:|
  Rat   170 -----LPLVNFKVSGIKFLKDKLVEIGAQKDELSFEQFHLFYKKLM----FEQQKSILDEFKKDS 225

  Fly   242 --------------FISLEQFIQFMNDKQRD---PRMNEILYPLYEEKRCTEIINDYELDEEKKK 289
                          .:.|:.|.:|:..:|::   ..:|::      .:|.|:.|     |:..::
  Rat   226 SVFILGNTDRPDASAVYLQDFQRFLLHEQQELWAQDLNKV------RERMTKFI-----DDTMRE 279

  Fly   290 NVQ--MSLDGFKRYLMSDENAPVFLDRLDF--YMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVE 350
            ..:  :.:|.|..||.|.||: ::.::.|.  ..:|:.||:||:|:|||||||:|.|:..:||.|
  Rat   280 TAEPFLFVDEFLTYLFSRENS-IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTE 343

  Fly   351 MYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFE 415
            .|.:.|.|||||:|||||:  |.|.:||:.||....|:|.|.|.:|||.|.|||:|.:|||||.|
  Rat   344 AYIRCLRAGCRCIELDCWD--GPDGKPIIYHGWTRTTKIKFDDVVQAIRDHAFVTSSFPVILSIE 406

  Fly   416 NHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRKILIKNKRMKP------E 474
            .||:..||..:||...:..|||||.:| .:...|   .||.|.:|:.||:||:|::.|      .
  Rat   407 EHCSVEQQRHMAKVFKEVLGDLLLTKP-TEASAD---QLPSPSQLREKIIIKHKKLGPRGDVDVN 467

  Fly   475 VE--------KVELELW--------------LKGELKTDDD----PEEDASAGKPP--------- 504
            ||        :.||.:|              ...:|...||    .|||.....||
  Rat   468 VEDKKDEHKTQGELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTVEEDPVQDTPPTELHFGEKW 532

  Fly   505 -----EAAAAPAPAPEAAAAAEGAAEG---------------------------------GGGA- 530
                 |:..:.....:...|..||.:|                                 .||.
  Rat   533 FHKKVESRTSAEKLLQEYCAETGAKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGVM 597

  Fly   531 ---------------------EAEAAAANYSGSTT------NVH---PW---------------- 549
                                 ||....|.:....|      |.|   ||
  Rat   598 KYYLTDNLTFNSIYALIQHYREAHLRCAEFELRLTDPVPNPNPHESKPWYYDRLSRGEAEDMLMR 662

  Fly   550 -----------------------------------------------LSSMV------------- 554
                                                           ..|:|
  Rat   663 IPRDGAFLIRKREGTDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHALYR 727

  Fly   555 ----------------------------------------------------------------- 554

  Rat   728 KMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELTFCR 792

  Fly   555 -----------------------------NYAQPI------------------------------ 560
                                         ||.:.|
  Rat   793 GALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISAGDAEEMEKQIIEDNPLGSLCRGILDLNT 857

  Fly   561 ---------------------KFQGFDKAIE---------------------------------- 570
                                 |.|| |..:|
  Rat   858 YNVVKAPQGKNQKAFVFILEPKKQG-DPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWE 921

  Fly   571 --KNIAHNMS-------------------------SFAESAGMNYLKQSSIDFVNYNKRQMSRIY 608
              ::||..:|                         ||.|:...:.::|..:|.:.||::.::|:|
  Rat   922 RNQSIAIELSDLVVYCKPTSKTKDHLENPDFREIRSFVETKADSIVRQKPVDLLRYNQKGLTRVY 986

  Fly   609 PKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFD 673
            |||.|.|||||.|...|..|.|||:||||:.|..||:|...|..||..||:|:|:.||  .:.:|
  Rat   987 PKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKYMQMNHALFSLNGRTGYVLQPESMR--SEKYD 1049

  Fly   674 PFADAPVDG--VIAAQCSVKVIAGQFLSDKKVG-----TYVEVDMFGLPSDTVKKEFRTRLVANN 731
            |.   |.:.  .|....:|||:..:.|  .|:|     .:|||::.|...|:.|  |:|.:|.:|
  Rat  1050 PM---PPESQRKILMTLTVKVLGARHL--PKLGRSIACPFVEVEICGAEYDSNK--FKTTVVNDN 1107

  Fly   732 GLNPVY--NEDPFVFRKVVLPDLAVLRFGVYEE----SGKILGQRILPLDGLQAGYRHVSLRTEA 790
            ||:||:  .::...| ::..|:||.|||.||||    ....|.....|:.|:::|:|.|.|:...
  Rat  1108 GLSPVWAPTQEKVTF-EIYDPNLAFLRFLVYEEDMFSDPNFLAHATYPIKGIKSGFRSVPLKNGY 1171

  Fly   791 NFPMSLPMLFVNIELKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIEEQSGGAARDAGK 855
            :..:.|..|.|..|::..:    |....:.|..|......::.|.|:......:...||.||| .
  Rat  1172 SEDIELASLLVFCEMRPVL----ESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRGANRDA-L 1231

  Fly   856 AKEEEKKEPPLVFEPVTLESLRQEKGFQKVGKKQI 890
            .||....|..|        .|.|||..:::.:|::
  Rat  1232 VKEFNVNENQL--------RLYQEKCNRRLREKRV 1258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	22/93 (24%)
		PLN02952	224..786	CDD:178538	220/988 (22%)
		EF-hand_like	227..318	CDD:286375	20/112 (18%)
		PI-PLCc_beta	318..653	CDD:176533	151/726 (21%)
		C2_PLC_like	689..806	CDD:175974	42/127 (33%)
		DUF1154	866..908	CDD:284131	6/25 (24%)
		Mer2	<887..1003	CDD:286200	1/4 (25%)
Plcg2	NP_058864.1	PH_PLC_gamma	22..140	CDD:270168	22/94 (23%)
		PH-like	235..>276	CDD:302622	9/51 (18%)
		PI-PLCc_gamma	311..>458	CDD:176534	76/152 (50%)
		PH-like	475..>510	CDD:302622	6/34 (18%)
		SH2_N-SH2_PLC_gamma_like	527..627	CDD:199829	10/99 (10%)
		SH2_C-SH2_PLC_gamma_like	641..744	CDD:198186	5/102 (5%)
		SH3_PLCgamma2	773..827	CDD:212902	2/53 (4%)
		PHsplit_PLC_gamma	<840..910	CDD:270054	5/70 (7%)
		PI-PLCc_GDPD_SF	<926..1031	CDD:301322	36/104 (35%)
		C2_PLC_like	1061..1187	CDD:175974	42/130 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920