DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment norpA and Plcb3

DIOPT Version :9

Sequence 1:NP_001014720.1 Gene:norpA / 31376 FlyBaseID:FBgn0262738 Length:1095 Species:Drosophila melanogaster
Sequence 2:NP_203501.1 Gene:Plcb3 / 29322 RGDID:61993 Length:1236 Species:Rattus norvegicus


Alignment Length:1184 Identity:422/1184 - (35%)
Similarity:638/1184 - (53%) Gaps:142/1184 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 PP----ELTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIR 74
            ||    .|..|..|.:|  :|:.:..|    ....:||..||||||.....:.|.:::..:.|.|
  Rat    15 PPTVVETLRRGSKFIKW--DEEASSRN----LVTLRVDPNGFFLYWTGPNMEVDTLDISSIRDTR 73

  Fly    75 AG---GTPKDPKILDKVTKKNGTNIPE--LDKRSLTICSNTDYINITYHHVICPDAATAKIWLDG 134
            .|   ..||||||.:.:    |...|:  |:::.:|:.:..|.:|.|:.:.:.....|.|:|.:.
  Rat    74 TGRYARLPKDPKIREVL----GFGGPDTRLEEKLMTVVAGPDPVNTTFLNFMAVQDDTVKVWSEE 134

  Fly   135 IRKITHNVKANNICPMMCLRKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDAGLPD 199
            :.|:..|:.|.|......|||.:.:|...|.:.|:||||.:.|.|::.|  |.|.|.::..||..
  Rat   135 LFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADK--KRVETALESCGLNF 197

  Fly   200 DKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSI-TKGKQDFISLEQFIQFMNDKQRDPRMNE 263
            :::.::..::|:.:.|....:|:|.|.||:::...| .||| .:::|||.:.|:|.||||||:||
  Rat   198 NRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGK-PYLTLEQLMDFINQKQRDPRLNE 261

  Fly   264 ILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHY 328
            :|||.....:...:|..||.:::..:..|||::||.|||..:||..:.|:.||..|:|.|||:.|
  Rat   262 VLYPPLRSSQARLLIEKYEPNKQFLERDQMSMEGFSRYLGGEENGILPLEALDLSMDMTQPLSAY 326

  Fly   329 YINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKD 393
            :|||||||||:..|:.|.||||||||.||.||||||||.|.|:..:|||.:|||....||:..:|
  Rat   327 FINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRD 391

  Fly   394 CIQAIADCAFVSSEYPVILSFENHCNRA-QQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPP 457
            .::|||:.||.:|.||||||||||.:.| ||.|:|:||...||:.||.:||..:||..|.|||.|
  Rat   392 VLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGEALLIDPLDKYPLSAGTPLPSP 456

  Fly   458 CKLKRKILIKN-KRMKPEVEKVELELWLKGELKTDDDPEEDASAGKPPEAAAAPAPA-------- 513
            ..|..:||:|| ||.:|.....:..: .|..|:..:....::||...|.:....:|:        
  Rat   457 QDLMGRILVKNKKRHRPSTGVPDSSV-RKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLS 520

  Fly   514 -------------PEAAAAAEGAAEGGG------------GAEAEAAAANYSGSTT--------- 544
                         |:.:...||...|..            ..|.|....:....||         
  Rat   521 NGEEVGLEKTSLEPQKSLGEEGLNRGPNVLMPDRDREDEEEDEEEEETTDPKKPTTDEGTASSEV 585

  Fly   545 NVHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYP 609
            |....:|::|||.:|:||:.|:.|.::|....||||.|:..|..|.:|.::||.|||:|:|||||
  Rat   586 NATEEMSTLVNYVEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYP 650

  Fly   610 KGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDP 674
            ||||.||||||||:|||.|||:|:||||:.|||||||.|.|||||..||||||:||||.||.|||
  Rat   651 KGTRVDSSNYMPQLFWNVGCQLVALNFQTLDLPMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDP 715

  Fly   675 FADAPVDGVIAAQCSVKVIAGQFLSDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNE 739
            |.:..|||::|....||||:||||||:|||.||||||||||.|| ::::|||....|..|||::|
  Rat   716 FTEVIVDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDT-RRKYRTRTSQGNSFNPVWDE 779

  Fly   740 DPFVFRKVVLPDLAVLRFGVYEESGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIE 804
            :||.|.|||||.||.||...:||.|:.:|.||||:..:::||.:|.||.|||.|:.||.|.:..|
  Rat   780 EPFDFPKVVLPTLASLRIAAFEEGGRFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYTE 844

  Fly   805 LKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIE---------------EQSGG--AARD 852
            ...|:||..:|:...|.:|........|:.:|:.||..|               :|.|.  ::..
  Rat   845 ASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQASTEMCQETPSQQQGSQLSSNP 909

  Fly   853 AGKAKEEEKKEPP-----------------------LVFE--PVTLESLRQEKGFQKVGKKQIKE 892
            |....:...:.||                       ::.|  |..||.||..|...|:..:|.::
  Rat   910 APNPLDASPRWPPGPTTSPTSTSLSSPGQRDDLIASILSEVTPTPLEELRSHKAMVKLRSRQDRD 974

  Fly   893 LDTLRKKHAKERTSVQKTQNAAIDKLIKGKSKDDIR----------NDANIKNSINDQTKQWTDM 947
            |..|.|||  :|.:|..|:. .:|.|.:.:::...|          |..::|....:..:|:.:.
  Rat   975 LRELHKKH--QRKAVALTRR-LLDGLAQARAEGKCRPSSSALSRATNVEDVKEEEKEAARQYREF 1036

  Fly   948 IARHRKE-----------EWDMLRQHVQDSQDAMKALML---TVQAAQIKQLEDRHARDIKDLNA 998
            ..|..:.           |.:...:|::.:|..::.::|   |.|..::|:|.:|..::::.:..
  Rat  1037 QNRQVQSLLELREAQADAETERRLEHLKQAQQRLREVVLDAHTTQFKRLKELNEREKKELQKILD 1101

  Fly   999 KQAKMSADTAKEVQNDKTLKTKNEKDRRLREKRQNNVKRFMEEKKQ----IGVKQGRAMEKLKLA 1059
            ::...|...||..:..|......|.:||...:..|:::|..|.:||    :...|.:.:::|...
  Rat  1102 RKRNNSISEAKTREKHKKEVELTEINRRHITESVNSIRRLEEAQKQRHERLLAGQQQVLQQLVEE 1166

  Fly  1060 HSKQIEEFSTDVQK 1073
            ..|.:.:.:.:.|:
  Rat  1167 EPKLVAQLTQECQE 1180

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
norpANP_001014720.1 PH_PLC_beta 17..149 CDD:270167 38/136 (28%)
PLN02952 224..786 CDD:178538 285/606 (47%)
EF-hand_like 227..318 CDD:286375 38/91 (42%)
PI-PLCc_beta 318..653 CDD:176533 167/378 (44%)
C2_PLC_like 689..806 CDD:175974 66/116 (57%)
DUF1154 866..908 CDD:284131 15/43 (35%)
Mer2 <887..1003 CDD:286200 25/139 (18%)
Plcb3NP_203501.1 PH_PLC_beta 22..149 CDD:270167 38/136 (28%)
EF-hand_like 225..315 CDD:286375 37/90 (41%)
PI-PLCc_beta 316..694 CDD:176533 167/378 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 467..588 19/121 (16%)
C2_PLC_like 729..844 CDD:175974 65/115 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 888..938 5/49 (10%)
DUF1154 952..989 CDD:284131 15/38 (39%)
FliJ <1031..1103 CDD:280262 11/71 (15%)
PLC-beta_C 1032..1204 CDD:285865 27/149 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1198..1236
Interaction with SHANK2. /evidence=ECO:0000269|PubMed:15632121 1233..1236
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 1 1.000 - - FOG0000126
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_102409
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.720

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