Protein Alignment norpA and Plcd3

DIOPT Version :10

• Sequence 1: NP_525069.2
• Gene: norpA / 31376
• FlyBaseID: FBgn0262738
• Length: 1095
• Species: Drosophila melanogaster
• Sequence 2: NP_001099315.3
• Gene: Plcd3 / 287745
• RGDID: 1310903
• Length: 785
• Species: Rattus norvegicus
• Alignment Length: 803
• Identity: 242/803 - (30%)
• Similarity: 386/803 - (48%)
• Gaps: 120/803 - (14%)

  Fly    34 KENDFERDALFKVDEYGFFLYWK---SEGRDGDVIELCQVSDIRAGGTPKDPKILDKVTKKNGTN 95
            :...:.::.|:::.|.|..::::   .......:..:..:..:|.|...      :.:.:..|..
  Rat    71 RSRTWHKERLYRLQEDGLSVWFQRRIPRAASQHIFFVQHIEAVREGHQS------EGLRRFGGAF 129

  Fly    96 IPELDKRSLTIC-----SNTDYINITYHHVICPDAATAKSWQKNLRLITHNNRATNVCPRVNLMK 155
            .|   .|.|||.     .|.|        :..|.|..|:.|.:.|..:.....|.:...|::
  Rat   130 AP---ARCLTIAFKGRRKNLD--------LAAPTAEEAQRWVRGLAKLRARLDAMSQRERLD--- 180

  Fly   156 HWMRLSYC----VEKSGKI---PVKTLAKTFASGKTEKLVYTCIKDAGLPDDKNATMTKEQFTFD 213
            ||:. ||.    .::..|:   .:|:|.:.......:...|...|:.   |..|    .|:....
  Rat   181 HWIH-SYLHRADSDQDSKMSFKEIKSLLRMVNVDMNDMYAYRLFKEC---DHSN----NERLEGA 237

  Fly   214 KFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPLYEEKRCTE-I 277
            :..|...::..|.::||:|...: |:...:|..:.::|:.|:..|.          ....|.: :
  Rat   238 EIEAFLRRLLKRPELEEIFRRYS-GEDRVLSASELLEFLEDQGEDG----------ATLACAQKL 291

  Fly   278 INDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYINSSHNTYLSGRQ 342
            |..|||:|..|::..|:||||..||:|.|.|.:.:.....:.:|.||||||:|:|||||||:..|
  Rat   292 IQTYELNETAKQHELMTLDGFMMYLLSPEGAALNVAHTCVFQDMGQPLAHYFISSSHNTYLTDSQ 356

  Fly   343 IGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSE 407
            |||.||.|.|.:....||||||||||.|.|  .||::.|||...::|||:|.|||:.|.||..|.
  Rat   357 IGGTSSTEAYIRAFTQGCRCVELDCWEGPG--GEPVIYHGHTLTSKILFRDVIQAVRDHAFTLSP 419

  Fly   408 YPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPL-PDHPLDPGLPLPPPCKLKRKILIKNKRM 471
            ||||||.||||...||..:|::..:..||:|:.:.| ..:|.:    ||.|.:||.::|:|.|::
  Rat   420 YPVILSLENHCGLEQQIVMARHLRNILGDMLVTQALDSQNPEE----LPSPEQLKCRVLVKGKKL 480

  Fly   472 KPEVEKVELELWLKGELKTD-DDPEEDASAGKPPEAAAAPAPAPEAAAAAEGAAEGGGGAEAEAA 535
             |.....:      |.:.:| :|.:||..               ||..|.|       .||....
  Rat   481 -PAARNED------GRILSDREDEDEDEE---------------EAEEALE-------TAEQRKR 516

  Fly   536 AANYSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYN 600
            |...|       |.||::|.|....:.:..:.:........:.|.:|.....:.:::...||.:|
  Rat   517 AKQIS-------PELSALVVYCCATRLRTLEPSPGPPQPCKIGSLSERKARKFTREAGTSFVRHN 574

  Fly   601 KRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFM 665
            .:|::|:||.|.|..|:||.||..||:|||:|:||||:....|.||.|:|..||.|||:|||.::
  Rat   575 TQQLTRVYPLGLRMTSANYNPQEMWNSGCQLVALNFQTPGYEMDLNTGRFLINGQCGYVLKPAYL 639

  Fly   666 RRADKDFDPFADAPVDGVIAAQCSVKVIAGQFL-------SDKKVGTYVEVDMFGLPSDTVKKEF 723
            |:.:..|||....|....:    :|:|:..|.|       .:..|...|.|:::|:|.|...||
  Rat   640 RQLNTTFDPECPGPPRTTL----TVQVLTAQQLPKLNVEKPNSIVDPLVRVEIYGVPEDCAHKE- 699

  Fly   724 RTRLVANNGLNPVYNED-PFVFRKVVLPDLAVLRFGV--YEES--GKILGQRILPLDGLQAGYRH 783
             |..|.|||.||.:.:. .|..|   .|:|.::||.|  |:.:  ...:||..|||:.|:.||||
  Rat   700 -TDYVLNNGFNPCWEQTLQFQLR---APELVLVRFVVEDYDTTSPNDFVGQFTLPLNSLKQGYRH 760

  Fly   784 VSLRTEANFPMSLPMLFVNIELK 806
            :.|.::....:|...|||:|.::
  Rat   761 IHLLSKDGASLSPATLFVHIRIE 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_525069.2	PH_PLC_beta	17..149	CDD:270167	19/122 (16%)
		EFh_NorpA_like	154..306	CDD:320042	37/159 (23%)
		EF-hand motif	154..183	CDD:320042	7/35 (20%)
		EF-hand motif	189..218	CDD:320042	5/28 (18%)
		EF-hand motif	227..256	CDD:320042	7/28 (25%)
		EF-hand motif	273..306	CDD:320042	15/33 (45%)
		PI-PLCc_beta	318..653	CDD:176533	127/336 (38%)
		C2_PLC_like	689..806	CDD:175974	43/128 (34%)
		DUF1154	865..909	CDD:461969
		PLC-beta_C	952..1073	CDD:462571
Plcd3	NP_001099315.3	PH_PLC_delta	61..177	CDD:270169	19/122 (16%)
		EF-hand_10	197..246	CDD:405477	9/55 (16%)
		PLN02228	251..783	CDD:177873	208/593 (35%)
		PI-PLCc_delta3	332..627	CDD:176567	127/336 (38%)