DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment norpA and Plch1

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	XP_006501593.1	Gene:	Plch1 / 269437	MGIID:	2683547	Length:	1694	Species:	Mus musculus

Alignment Length:	1242	Identity:	312/1242 - (25%)
Similarity:	517/1242 - (41%)	Gaps:	325/1242 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LFKVDEYGFFLYWK------------------SEGRDGDVIELCQVSDIRAGGTPKDPKILDKVT 89
            ||.:||:...|.|:                  :|||..::..       |......||...  .|
Mouse    53 LFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSEIFH-------RQAEGNFDPSCC--FT 108

  Fly    90 KKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKIWLDGIRKITHNVK-ANNICPMMCL 153
            ..:|.::..||    .|.||.:               .|:.|:.|::.:...:. .:::......
Mouse   109 IYHGNHMESLD----LITSNPE---------------EARTWITGLKYLMAGISDEDSLAKRQRT 154

  Fly   154 RKHWMRLSY-CVEKSG------------------KIPVKTLAKTFASGKTEKLVYTCIKDAGLPD 199
            ...|::.:: ..:|:|                  .:|.:.:.:.|....|              |
Mouse   155 HDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADT--------------D 205

  Fly   200 DKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEI 264
            :...|:     ||::|...|..:..|.|:..|..|.: .|:|.:::|:..||:..:|   :|:.:
Mouse   206 ENQGTL-----TFEEFCVFYKMMSLRRDLYLLLLSYS-DKKDHLTVEELAQFLKVEQ---KMSNV 261

  Fly   265 LYPLYEEKRCTEIINDYELDEEKK-KNVQMSLDGFKRYLMS---DENAPVFLDRLDFYMEMDQPL 325
            ....     |.:||..:|:.||.| ||| :.::||..::.|   |...|:   ..:.|.:|||||
Mouse   262 TLDY-----CLDIIMKFEVSEENKVKNV-LGIEGFTNFMRSPACDVFNPL---HHEVYQDMDQPL 317

  Fly   326 AHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEIL 390
            .:|||.|||||||:|.|:..:|.|:||.:.|..||||||:|||:  |.|.||:|.||:...::||
Mouse   318 CNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWD--GPDGEPVVHHGYTLTSKIL 380

  Fly   391 FKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPG--LP 453
            |:|.::.|...|||.:|:|||||.||||:..||.|:|:|...     :|::.|....:|.|  ..
Mouse   381 FRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKG-----ILQDKLDLSSVDTGECRQ 440

  Fly   454 LPPPCKLKRKILIKNKRM------------------KPEVE----------------------KV 478
            ||.|..||.|||:|.|::                  ..|:|                      :.
Mouse   441 LPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRK 505

  Fly   479 ELELWLK-GELKTDDDPEE------------------------------------DASAGKPPEA 506
            :||..|| .:::..:||:.                                    .|:.||..:.
Mouse   506 KLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQNLDVKESGKKSHGRSLMANFGKHKQK 570

  Fly   507 AAAPAPAPEAAAAAEGAAEGGGGAEAEAAAANYSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEK 571
            |........:....:.:.:..|....:.........|..:...||.:|.|...:..|..   ::.
Mouse   571 ATKSRSKSYSTDDEDDSLQNPGKEGGQLYRLGRRRRTMKLCRELSDLVVYTNSVAAQDI---VDD 632

  Fly   572 NIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNF 636
            ....|:.||:|:.....::|.|..|:.||::|::||||...|.||||:.|..:||||||:|:||:
Mouse   633 GTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNY 697

  Fly   637 QSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQFL--- 698
            ||....||:|:.||:.||.|||:|||..|.:.  .|:||:..|:......|..:|||:||.|
Mouse   698 QSEGRMMQINRAKFKANGNCGYILKPQQMCKG--TFNPFSGDPLPANPKKQLILKVISGQQLPKP 760

  Fly   699 SDKKVG-------TYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRKVVLPDLAVLR 756
            .|...|       .:|||::.|||.|..|.:  ||:|.:||.|||: |:...| .|.:|::|::|
Mouse   761 PDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ--TRVVDDNGFNPVW-EETLTF-TVHMPEIALVR 821

  Fly   757 FGVYEES--GK-ILGQRILPLDGLQAGYRHVSLR--TEANFPMSLPMLFVNIELKIYVPDGFEDF 816
            |.|::..  |: .:|||.:....|..|||||.|.  |||:       :||:|.:.    :.|..:
Mouse   822 FLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEAS-------IFVHITIN----EIFGKW 875

  Fly   817 MAMLSDPR----GFAGAAKQQNEQMKALGIEEQSGGAARDAGKAKEEEKKEPPLVFEPVTLESLR 877
            ..::.:|.    .|.||.|  |.|::.|
Mouse   876 SPLILNPSYTILHFLGATK--NRQLQGL------------------------------------- 901

  Fly   878 QEKG-FQKVGKKQIKELDT--LRKKHAKERTSVQKTQNAAIDKLIKG--KSKDDIRNDANIKNSI 937
              || |.|..:....|.::  :||:...:|. :::|.:|.    .||  |||...:....||:|:
Mouse   902 --KGLFNKNPRHASSENNSHYVRKRSIGDRI-LRRTASAP----AKGRKKSKVGFQEMVEIKDSV 959

  Fly   938 NDQTKQWTDMIARHRKEEWDMLRQHVQDSQDAMKALMLTV-QAAQIKQLEDRHARDIKDLNAKQA 1001
            ::.::. .|.:.|.......:....:...:..:.||.|.: :||:....::......||...|.|
Mouse   960 SEASRD-QDGVLRRTTRSLQVRPVSMPVDKSLLGALSLPISEAAKDTDGKENCLAGDKDDRRKGA 1023

  Fly  1002 -------------KMSADTA----KEVQNDKTLKTKN--------EKDRRLREKRQN------NV 1035
                         |:|:.::    |:.....|....|        .|..|::....|      |.
Mouse  1024 ATRKDPHFSNFNKKLSSSSSALLHKDANQGPTASVSNPEQCGGRGAKSERIKPNMTNDCQENHNP 1088

  Fly  1036 KRFMEEKKQIGVKQG-----RAMEKLKLAHSKQIEEF---------STDVQKLMDMYKIEEEAYK 1086
            .:|:..:|.:.:...     ..:..:|....:..|.|         |...|..:::..:|....|
Mouse  1089 PKFLSPRKHLALDPATKGLQERLHGMKTNEKEHAEGFLGEKSMLSGSVLSQSSLEVENLEGSRAK 1153

  Fly  1087 TQGKTEF 1093
            .:..|.|
Mouse  1154 GRAATSF 1160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	22/124 (18%)
		PLN02952	224..786	CDD:178538	213/657 (32%)
		EF-hand_like	227..318	CDD:286375	25/94 (27%)
		PI-PLCc_beta	318..653	CDD:176533	131/413 (32%)
		C2_PLC_like	689..806	CDD:175974	49/131 (37%)
		DUF1154	866..908	CDD:284131	8/44 (18%)
		Mer2	<887..1003	CDD:286200	25/133 (19%)
Plch1	XP_006501593.1	PH-like	34..140	CDD:388408	22/114 (19%)
		EFh_PI-PLCeta1	158..298	CDD:320050	36/168 (21%)
		EF-hand motif	158..187	CDD:320050	3/28 (11%)
		EF-hand motif	194..223	CDD:320050	8/47 (17%)
		EF-hand motif	228..256	CDD:320050	8/28 (29%)
		EF-hand motif	265..298	CDD:320050	13/38 (34%)
		PI-PLCc_eta1	310..714	CDD:176569	131/413 (32%)
		C2_PLC_like	744..868	CDD:175974	50/134 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820