DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment norpA and plc1

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	NP_594734.1	Gene:	plc1 / 2541439	PomBaseID:	SPAC22F8.11	Length:	899	Species:	Schizosaccharomyces pombe

Alignment Length:	857	Identity:	223/857 - (26%)
Similarity:	365/857 - (42%)	Gaps:	177/857 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VPPELTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIRAGG 77
            ||..:..||...|  ..:|:.::.....|.:     .|:.:..|:.|:....:.:..:.:||.|.
pombe   161 VPESIQNGCSLLR--ITKKKVRQRKVSLDPI-----SGYLMLDKNTGKAYKKLCVDDIKEIRQGR 218

  Fly    78 TPKDPKILDKVTKKNGTNIPELDKRSLTI--CSNTDYINITYHHVICPDAATAKIW---LDGIRK 137
            ..::.:...|::.:|       :||..||  |::.   .:...|:|.|.......|   |:|::.
pombe   219 DARNYREQYKISSEN-------EKRWFTIIYCADN---KLKAMHMISPTLDAHNQWIMALEGLKT 273

  Fly   138 ITHN---VKANNIC----PMMCLRKH---WMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCI 192
            ...|   :..|.:|    .|:...::   |.:|.  .|:|.::.:         |...::....
pombe   274 YRLNEFIIGLNLVCHQGEKMIDYSENLNPWEKLE--KEQSAQLDL---------GDVHRMCQML- 326

  Fly   193 KDAGLPDDKNATMTKEQFTFDK----------FYALYHKVC---PRNDIEELFTSITKGKQDFIS 244
                   ..||:|...:.||.|          |....|.|.   .|::|.::|...|.| .|.:|
pombe   327 -------HLNASMEFLEETFQKADADHSGKLSFEEFQHFVSLLKTRSEIVDIFKEYTSG-SDKMS 383

  Fly   245 LEQFIQFMNDKQRDPRMNEILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAP 309
            ||||..|::..|:....::.:..||        ::....|:.|     |.|..|..:|:|..|:|
pombe   384 LEQFRHFLSTSQKARLDSDSIRTLY--------VSFCSNDDSK-----MGLIEFTSFLLSPHNSP 435

  Fly   310 VFLDRLDFYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGED 374
            |    :....:|.:||..|.|:|||||||.|:|.||:||:|.|.::|..||:|:|:|||:|   .
pombe   436 V----VPVIQDMSRPLNEYLISSSHNTYLLGKQFGGESSIEGYIRSLQRGCKCIEIDCWDG---P 493

  Fly   375 EEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLL 439
            ..|:|.|||.:.:.|.|.|.|.||...|||.|.||:.:|.|.||...||.::..|....|||.|:
pombe   494 NGPVVCHGHTFTSMIKFNDVIDAIRKYAFVVSPYPLFISLEIHCCPDQQRQMVSYMKQAFGDTLV 558

  Fly   440 KEPLPDHPLDPGLPLPPPCKLKRKILIKNKRMKPEVEKVELELWLKGELKTDDDPEEDASAGKPP 504
            .:|:..:.    ..||.|..|..|||:|.|.....:.:...::...|...:..|..|.:....
pombe   559 MKPVTANE----SVLPSPEDLLNKILLKVKCSATPLHQFSTDILKVGITDSSTDTTESSELEN-- 617

  Fly   505 EAAAAPAPAPEAAAAAEGAAEGGGGAEAEAAAANYSGSTTNVHPWLSSMVNYAQPIKFQGFDKAI 569
                               :|..|..:.:....|.      :...|..:..||:.:||:.|....
pombe   618 -------------------SELTGLRKGKRRMKNI------IVQELQQLAPYARSLKFRNFSLPE 657

  Fly   570 EKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSL 634
            .|..:| :.||:|.....:.|........:|.|.:.|:||...|..|:|:.|||:|..|.|||:|
pombe   658 SKTYSH-IFSFSERTIKKHGKAMVPRLSKHNLRYLCRVYPGPLRVGSTNFNPQVYWRLGVQMVAL 721

  Fly   635 NFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAA-----------QC 688
            |:|:.|..:|:|...|..:...||||||                |...:|..           :.
pombe   722 NWQTYDTGLQINDALFIADPPTGYLLKP----------------PCQRIIGTTVGEEGLPRKIKL 770

  Fly   689 SVKVIAGQFL-------SDKKVGTYVEVDMFGLPSDTVKKEFR--TRLVANNGLNPVYNEDPFVF 744
            ::.||:||.|       :.:.:..|||:.:..:.    :..||  :::|..||..|.:.| ..|:
pombe   771 TIDVISGQQLRRARELSNSETLSPYVEIQVHSME----ESPFRWCSKVVHENGFRPFWGE-TMVY 830

  Fly   745 RKVVLPDL-AVLRFGVYEE----SGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPM-----L 799
            ..::..|. :::||.|:..    :..|......|:|.||.||||:.|         |.|     |
pombe   831 ESIISDDFYSMIRFLVHHRGSNGNDSIFANFTCPIDRLQQGYRHIRL---------LDMQGENLL 886

  Fly   800 FVNIELKIYVPD 811
            |.::.|||...|
pombe   887 FSSLFLKIKKED 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	27/143 (19%)
		PLN02952	224..786	CDD:178538	170/586 (29%)
		EF-hand_like	227..318	CDD:286375	24/90 (27%)
		PI-PLCc_beta	318..653	CDD:176533	108/334 (32%)
		C2_PLC_like	689..806	CDD:175974	34/135 (25%)
		DUF1154	866..908	CDD:284131
		Mer2	<887..1003	CDD:286200
plc1	NP_594734.1	PH_PLC_fungal	165..277	CDD:241514	24/128 (19%)
		EFh	303..360	CDD:238008	13/75 (17%)
		EF-hand_7	303..359	CDD:290234	13/74 (18%)
		PLN02228	367..883	CDD:177873	172/598 (29%)
		EF-hand_like	367..438	CDD:286375	24/88 (27%)
		PI-PLC1c_yeast	441..737	CDD:176540	107/330 (32%)
		C2_PLC_like	767..897	CDD:175974	37/143 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	76	1.000	Domainoid score	I2445
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10336
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.910