DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment norpA and Plcb1

DIOPT Version :9

Sequence 1:NP_001014720.1 Gene:norpA / 31376 FlyBaseID:FBgn0262738 Length:1095 Species:Drosophila melanogaster
Sequence 2:NP_001071109.1 Gene:Plcb1 / 24654 RGDID:3344 Length:1216 Species:Rattus norvegicus


Alignment Length:1157 Identity:432/1157 - (37%)
Similarity:647/1157 - (55%) Gaps:127/1157 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 ELTTGCVFDRWFENEKETKEND---FERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIRAG- 76
            :|...||.|...:..|..|.:|   .....:.:.|..|||.||..:.::.::::|..|.|.|.| 
  Rat    12 QLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGK 76

  Fly    77 --GTPKDPKILDKVTKKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKIWLDGIRKIT 139
              ..|||||:.:.:   :..||..|::|.:|:....|.:||::.:::......||.|.:.:..:.
  Rat    77 HAKAPKDPKLRELL---DVGNIGHLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLA 138

  Fly   140 HNVKANNICPMMCLRKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDAGLPDDKNAT 204
            .|:.|.|:.....|.|.:.:|...|...|:||:|.:.:.|::.:  |.|.|.::...||..:|.:
  Rat   139 TNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADR--KRVETALEACSLPSSRNDS 201

  Fly   205 MTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPLY 269
            :.:|.||.|.:....:.:|||.:|:.:|:......:.:::::|.:.|:|.||||||:||||||..
  Rat   202 IPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPL 266

  Fly   270 EEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYINSSH 334
            ::::...:|..||.:....|..|||:|||.|||..:||..|..::||...:|.|||:||:|||||
  Rat   267 KQEQVQVLIEKYEPNSSLAKKGQMSVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSH 331

  Fly   335 NTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIA 399
            ||||:..|:.|.||||||||.||:||||||||||.|:..:|||::|||....|||.||:.|:|||
  Rat   332 NTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIA 396

  Fly   400 DCAFVSSEYPVILSFENHCNR-AQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRK 463
            :|||.:|.:|::||||||.:. .||.|:|:||...|||.||.|||..:||:.|:|||.|..|..|
  Rat   397 ECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYK 461

  Fly   464 ILIKNKRMKPEVEKVELELWLKGELKTDDDPEEDASAGKPPEAAAAPAPAPEAAAAAEGAAEGGG 528
            ||:|||:                  |:....|   .:||...:..|.....::::..|.::.|.|
  Rat   462 ILVKNKK------------------KSHKSSE---GSGKKKLSEQASNTYSDSSSVFEPSSPGAG 505

  Fly   529 GAEAE-------------AAAANYSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSF 580
            .|:.|             :.....:||.......:|::|||.||:||:.|:.:.::|.:..||||
  Rat   506 EADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFETSKKRNKSFEMSSF 570

  Fly   581 AESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQL 645
            .|:.|:..|.:|.::||.|||.|:|||||||||.||||||||:|||||||||:||||:.||.||:
  Rat   571 VETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQI 635

  Fly   646 NQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQFLSDKKVGTYVEVD 710
            |.|.:||||..||.|||:||||.||.||||.:..|||::|...|||:|:||||||||||||||||
  Rat   636 NMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVD 700

  Fly   711 MFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRKVVLPDLAVLRFGVYEESGKILGQRILPLD 775
            |||||.||.:|.|:|:....|.:|||:.|:|.||:|||||.||.||...|||.||.:|.||||:.
  Rat   701 MFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQ 765

  Fly   776 GLQAGYRHVSLRTEANFPMSLPMLFVNIELKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKAL 840
            .::.||.::.||.|.|.|:.||.:||.||:|.||||.:.|.:..||:|..:....:|:.:|:.||
  Rat   766 AIRPGYHYICLRNERNQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAAL 830

  Fly   841 GIE-EQSGGAARDAGKAKEEEKKE-------------------PP-------------------- 865
            .:| |:......|.|:...|...|                   ||                    
  Rat   831 TLEDEEEVKKEADPGETSSEAPSETRTTPAENGVNHTATLAPKPPSQAPHSQPAPGSVKAPAKTE 895

  Fly   866 -LV------FEPVTLESLRQEKGFQKVGKKQIKELDTLRKKHAKERTSVQKTQNAAIDKLIKGKS 923
             |:      .|..|:|.|:|:|.|.|:.||..||:..|.|:|.|:.|.:.|......:::    .
  Rat   896 DLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTELIKEHTTKYNEI----Q 956

  Fly   924 KDDIRNDANIKNSINDQTKQWTDMIARHRKE---EWDM------LRQHVQDSQDAMKALMLTVQA 979
            .|.:|..|.::.|....:|:.::..:.....   |.|:      :.|.:.|.:|..:..:|.::.
  Rat   957 NDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSAIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQ 1021

  Fly   980 AQIKQLEDRHARDIKDLNAKQAKMSADTAKEVQNDKTLKTKNEKDRRLREKRQNNVKRFMEEKKQ 1044
            .|....:.:....||.|..|    ..|.|:|.||::..|.|     .:.||.:..:|:.|::|:|
  Rat  1022 EQYYSEKYQKREHIKLLIQK----LTDVAEECQNNQLKKLK-----EICEKEKKELKKKMDKKRQ 1077

  Fly  1045 IGVKQGRAMEKLKLAHSKQIEEFSTD-----VQKLMDMYK-IEEEAYKTQGK 1090
            ..:.:.::.:|      .|:||..|:     :|:::...| :||...|.|.|
  Rat  1078 EKITEAKSKDK------SQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEK 1123

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
norpANP_001014720.1 PH_PLC_beta 17..149 CDD:270167 37/137 (27%)
PLN02952 224..786 CDD:178538 283/575 (49%)
EF-hand_like 227..318 CDD:286375 35/90 (39%)
PI-PLCc_beta 318..653 CDD:176533 165/348 (47%)
C2_PLC_like 689..806 CDD:175974 70/116 (60%)
DUF1154 866..908 CDD:284131 18/47 (38%)
Mer2 <887..1003 CDD:286200 26/124 (21%)
Plcb1NP_001071109.1 PH_PLC_beta 22..148 CDD:270167 33/128 (26%)
PLN02952 216..784 CDD:178538 288/588 (49%)
EF-hand_like 224..314 CDD:286375 34/89 (38%)
PI-PLCc_beta 316..643 CDD:176533 165/347 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 469..534 12/67 (18%)
C2_PLC_like 677..796 CDD:175974 70/118 (59%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 834..891 7/56 (13%)
DUF1154 903..939 CDD:284131 15/35 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 967..989 2/21 (10%)
PLC-beta_C 1003..1172 CDD:285865 34/136 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1072..1095 7/28 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1172..1216
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 1 1.000 - - FOG0000126
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_102409
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.720

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