DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment norpA and Plcg2

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	NP_758489.1	Gene:	Plcg2 / 234779	MGIID:	97616	Length:	1265	Species:	Mus musculus

Alignment Length:	1266	Identity:	279/1266 - (22%)
Similarity:	448/1266 - (35%)	Gaps:	498/1266 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 KSEGRDGDVIELCQVSDIRAGGTPKDPKILDKVTKKNGTNIPELDKRSLTICSNTDYINITYHHV 120
            |.||    .:::.::.:||.|...||.:....|..|        .:...||...|.::..|..
Mouse    60 KIEG----FLDIMEIKEIRPGKNSKDFERAKAVRHK--------AECCFTILYGTQFVLSTLS-- 110

  Fly   121 ICPDAATAKI-WLDGIRKITHNVKANNICPMMCLRKHWMRLS-YCVEKS--GKIPVKTLAKTFAS 181
            :..|:....: ||.|: ||.|....:...|.|.  :.|:|.. |.|:::  ..|.::.| ||.
Mouse   111 LATDSKEDAVKWLSGL-KILHQEAMSASTPTMI--ESWLRKQIYSVDQTRRNSISLREL-KTI-- 169

  Fly   182 GKTEKLVYTCIKDAGLPDDKNATM----TKEQFTFDKFYALYHKVC---PRNDIEE--------L 231
                 |.....|.:|:...|:..:    .|::.:|::|:..|.|:.   .::.::|        :
Mouse   170 -----LPLVNFKVSGIKFLKDKLVEIGAQKDELSFEQFHLFYKKLMFDQQKSILDEFKKDSSVFI 229

  Fly   232 FTSITKGKQDFISLEQFIQFMNDKQRD---PRMNEILYPLYEEKRCTEIINDYELDEEKKKNVQ- 292
            ..:..:.....:.|:.|.:|:..:|::   ..:|::      .:|.|:.|     |:..::..:
Mouse   230 LGNTDRPDASAVYLQDFQRFLLHEQQELWAQDLNKV------RERMTKFI-----DDTMRETAEP 283

  Fly   293 -MSLDGFKRYLMSDENAPVFLDRLDF--YMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQ 354
             :.:|.|..||.|.||: ::.::.|.  ..:|:.||:||:|:|||||||:|.|:..:||.|.|.:
Mouse   284 FLFVDEFLTYLFSRENS-IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIR 347

  Fly   355 TLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCN 419
            .|.|||||:|||||:  |.|.:||:.||....|:|.|.|.:|||.|.|||:|.:|||||.|.||:
Mouse   348 CLRAGCRCIELDCWD--GPDGKPIIYHGWTRTTKIKFDDVVQAIRDHAFVTSSFPVILSIEEHCS 410

  Fly   420 RAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRKILIKNKRMKPE------VE-- 476
            ..||..:||...:..||:||.:| .:...|   .||.|.:|:.||:||:|::.|:      ||
Mouse   411 VEQQRHMAKVFKEVLGDMLLTKP-TEASAD---QLPSPSQLREKIIIKHKKLGPKGDVDVNVEDK 471

  Fly   477 ------KVELELW--------------LKGELKTDDD----PEEDASAGKPP------------- 504
                  :.||.:|              ...:|...||    .||:.....||
Mouse   472 KDEHKPQGELYMWDSIDQKWTRHYCAIADAKLSFGDDIEQAVEEEPVQDTPPTELHFGEKWFHKK 536

  Fly   505 -EAAAAPAPAPEAAAAAEGAAEG---------------------------------GGGA----- 530
             |:..:.....:...|..||.:|                                 ..|.
Mouse   537 VESRTSAEKLLQEYCAETGAKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMENGVMKYYL 601

  Fly   531 -----------------EAEAAAANYSGSTT------NVH---PW-------------------- 549
                             ||....|.:....|      |.|   ||
Mouse   602 TDNLTFNSIYALIQHYREAHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDMLMRIPRD 666

  Fly   550 -------------------------------------------LSSMV----------------- 554
                                                       ..|:|
Mouse   667 GAFLIRKREGTNSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHALYRKMRL 731

  Fly   555 ----------------------------------------------------------------- 554

Mouse   732 RYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELTFCRGALI 796

  Fly   555 -------------------------NYAQPI---------------------------------- 560
                                     ||.:.|
Mouse   797 HNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISAGDAEEMEKQIIEDNPLGSLCKGILDLNTYNVV 861

  Fly   561 -----------------KFQGFDKAIE------------------------------------KN 572
                             |.|| |..:|                                    ::
Mouse   862 KAPQGKNQKAFVFILEPKKQG-DPPVEFATDRVEELFEWFQSIREITWKMDTKENNMKYWERNQS 925

  Fly   573 IAHNMS-------------------------SFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGT 612
            ||..:|                         ||.|:...:.::|..:|.:.||::.::|:||||.
Mouse   926 IAIELSDLVVYCKPTSKTKDHLENPDFREIRSFVETKADSIVRQKPVDLLRYNQKGLTRVYPKGQ 990

  Fly   613 RADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFAD 677
            |.|||||.|...|..|.|||:||||:.|..||:|...|..||..||:|:|:.||  .:.:||.
Mouse   991 RVDSSNYDPFRLWLCGSQMVALNFQTPDKYMQMNHALFSLNGRTGYVLQPESMR--SEKYDPM-- 1051

  Fly   678 APVDG--VIAAQCSVKVIAGQFLSDKKVG-----TYVEVDMFGLPSDTVKKEFRTRLVANNGLNP 735
             |::.  .|....:|||:..:.|  .|:|     .:|||::.|...|:.|  |:|.:|.:|||:|
Mouse  1052 -PLESQRKILMTLTVKVLGARHL--PKLGRSIACPFVEVEICGAEYDSNK--FKTTVVNDNGLSP 1111

  Fly   736 VY--NEDPFVFRKVVLPDLAVLRFGVYEE----SGKILGQRILPLDGLQAGYRHVSLRTEANFPM 794
            |:  .::...| ::..|:||.|||.||||    ....|.....|:.|:::|:|.|.|:...:..:
Mouse  1112 VWAPTQEKVTF-EIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDI 1175

  Fly   795 SLPMLFVNIELKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIEEQSGGAARDAGKAKEE 859
            .|..|.|..|::..:    |....:.|..|......::.|.|:......:...||.||| ..||.
Mouse  1176 ELASLLVFCEMRPVL----ESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRGANRDA-LVKEF 1235

  Fly   860 EKKEPPLVFEPVTLESLRQEKGFQKVGKKQI 890
            ...|..|        .|.|||..:::.:|::
Mouse  1236 NVNENQL--------QLYQEKCNRRLREKRV 1258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	21/93 (23%)
		PLN02952	224..786	CDD:178538	215/981 (22%)
		EF-hand_like	227..318	CDD:286375	18/105 (17%)
		PI-PLCc_beta	318..653	CDD:176533	148/726 (20%)
		C2_PLC_like	689..806	CDD:175974	42/127 (33%)
		DUF1154	866..908	CDD:284131	6/25 (24%)
		Mer2	<887..1003	CDD:286200	1/4 (25%)
Plcg2	NP_758489.1	PH_PLC_gamma	22..140	CDD:270168	21/94 (22%)
		PH-like	235..>276	CDD:302622	9/51 (18%)
		PI-PLCc_gamma	311..>458	CDD:176534	75/152 (49%)
		PH-like	475..>512	CDD:302622	6/36 (17%)
		SH2_N-SH2_PLC_gamma_like	527..627	CDD:199829	9/99 (9%)
		SH2_C-SH2_PLC_gamma_like	641..744	CDD:198186	5/102 (5%)
		SH3_PLCgamma2	773..827	CDD:212902	2/53 (4%)
		PHsplit_PLC_gamma	<840..909	CDD:270054	5/69 (7%)
		PI-PLCc_GDPD_SF	<926..1031	CDD:301322	36/104 (35%)
		C2_PLC_like	1061..1187	CDD:175974	42/130 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820