DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment norpA and PLCB1

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	NP_056007.1	Gene:	PLCB1 / 23236	HGNCID:	15917	Length:	1216	Species:	Homo sapiens

Alignment Length:	1157	Identity:	430/1157 - (37%)
Similarity:	649/1157 - (56%)	Gaps:	127/1157 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ELTTGCVFDRWFENEKETKEND---FERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIRAG- 76
            :|...||.|...:..|..|.:|   .....:.:.|..|||.||..:.::.::::|..|.|.|.|
Human    12 QLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGR 76

  Fly    77 --GTPKDPKILDKVTKKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKIWLDGIRKIT 139
              ..|||||:.:.:   :..||..|::|.:|:....|.:||::.:::......||.|.:.:..:.
Human    77 HAKAPKDPKLRELL---DVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLA 138

  Fly   140 HNVKANNICPMMCLRKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDAGLPDDKNAT 204
            .|:.|.|:.....|.|.:.:|...|...|:||:|.:.:.|::.:  |.|.|.::...||..:|.:
Human   139 TNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADR--KRVETALEACSLPSSRNDS 201

  Fly   205 MTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPLY 269
            :.:|.||.:.:....:.:|||.:|:.:|:......:.:::::|.:.|:|.||||||:||||||..
Human   202 IPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPL 266

  Fly   270 EEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYINSSH 334
            ::::...:|..||.:....:..|:|:|||.|||..:||..|..::||...:|.|||:||:|||||
Human   267 KQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSH 331

  Fly   335 NTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIA 399
            ||||:..|:.|.||||||||.||:||||||||||.|:..:|||::|||....|||.||:.|:|||
Human   332 NTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIA 396

  Fly   400 DCAFVSSEYPVILSFENHCNR-AQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRK 463
            :|||.:|.:|::||||||.:. .||.|:|:||...|||.||.|||..:||:.|:|||.|..|..|
Human   397 ECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYK 461

  Fly   464 ILIKNKRMKPEVEKVELELWLKGELKTDDDPEEDASAGKPPEAAAAPAPAPEAAAAAEGAAEGGG 528
            ||:|||:                  |:....|   .:||...:..|.....::::..|.::.|.|
Human   462 ILVKNKK------------------KSHKSSE---GSGKKKLSEQASNTYSDSSSMFEPSSPGAG 505

  Fly   529 GAEAE-------------AAAANYSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSF 580
            .|:.|             :.....:||.......:|::|||.||:||:.|:.:.::|.:..||||
Human   506 EADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSF 570

  Fly   581 AESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQL 645
            .|:.|:..|.:|.::||.|||.|:|||||||||.||||||||:|||||||||:||||:.||.||:
Human   571 VETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQI 635

  Fly   646 NQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQFLSDKKVGTYVEVD 710
            |.|.:||||..||.|||:||||.||.||||.:..|||::|...|||:|:||||||||||||||||
Human   636 NMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVD 700

  Fly   711 MFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRKVVLPDLAVLRFGVYEESGKILGQRILPLD 775
            |||||.||.:|.|:|:....|.:|||:.|:|.||:|||||.||.||..||||.||.:|.||||:.
Human   701 MFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQ 765

  Fly   776 GLQAGYRHVSLRTEANFPMSLPMLFVNIELKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKAL 840
            .::.||.::.||.|.|.|::||.:||.||:|.||||.:.|.:..||:|..:....:|:.:|:.||
Human   766 AIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAAL 830

  Fly   841 GIE-EQSGGAARDAGKAKEEEKKE-------------------PP-------------------- 865
            .:| |:......|.|:...|...|                   ||
Human   831 TLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTE 895

  Fly   866 -LV------FEPVTLESLRQEKGFQKVGKKQIKELDTLRKKHAKERTSVQKTQNAAIDKLIKGKS 923
             |:      .|..|:|.|:|:|.|.|:.||..||:..|.|:|.|:.|.:.|......:::    .
Human   896 DLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEI----Q 956

  Fly   924 KDDIRNDANIKNSINDQTKQWTDMIARHRKE---EWDM------LRQHVQDSQDAMKALMLTVQA 979
            .|.:|..|.::.|....:|:.::..:.....   |.|:      :.|.:.|.:|..:..:|.::.
Human   957 NDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQ 1021

  Fly   980 AQIKQLEDRHARDIKDLNAKQAKMSADTAKEVQNDKTLKTKNEKDRRLREKRQNNVKRFMEEKKQ 1044
            .|....:.:....||.|..|    ..|.|:|.||::..|.|     .:.||.:..:|:.|::|:|
Human  1022 EQYYSEKYQKREHIKLLIQK----LTDVAEECQNNQLKKLK-----EICEKEKKELKKKMDKKRQ 1077

  Fly  1045 IGVKQGRAMEKLKLAHSKQIEEFSTD-----VQKLMDMYK-IEEEAYKTQGK 1090
            ..:.:.::.:|      .|:||..|:     :|:::...| :||...|.|.|
Human  1078 EKITEAKSKDK------SQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEK 1123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	37/137 (27%)
		PLN02952	224..786	CDD:178538	282/575 (49%)
		EF-hand_like	227..318	CDD:286375	33/90 (37%)
		PI-PLCc_beta	318..653	CDD:176533	165/348 (47%)
		C2_PLC_like	689..806	CDD:175974	71/116 (61%)
		DUF1154	866..908	CDD:284131	18/47 (38%)
		Mer2	<887..1003	CDD:286200	26/124 (21%)
PLCB1	NP_056007.1	PH_PLC_beta	22..148	CDD:270167	33/128 (26%)
		EFh_PI-PLCbeta1	153..303	CDD:320038	48/151 (32%)
		EF-hand motif	153..182	CDD:320038	8/28 (29%)
		EF-hand motif	186..215	CDD:320038	7/28 (25%)
		EF-hand motif	224..253	CDD:320038	5/28 (18%)
		EF-hand motif	270..303	CDD:320038	11/32 (34%)
		PI-PLCc_beta	316..643	CDD:176533	165/347 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	469..534		12/67 (18%)
		C2_PLC_like	677..796	CDD:175974	71/118 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..891		7/56 (13%)
		DUF1154	903..939	CDD:369010	15/35 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	963..994		4/30 (13%)
		PLC-beta_C	1003..1172	CDD:370077	34/136 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1071..1095		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1173..1216
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102409
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750