DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment norpA and PLCL2

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	NP_001137854.1	Gene:	PLCL2 / 23228	HGNCID:	9064	Length:	1127	Species:	Homo sapiens

Alignment Length:	1094	Identity:	281/1094 - (25%)
Similarity:	450/1094 - (41%)	Gaps:	232/1094 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KETKENDFERDALFKVDEYGFFLYWKSEGRDGD--VIELCQVSDIRAGGTPKDPKILDKVTKKNG 93
            |:.:.|.......|.:|.....|.|:...:|.:  .|::..:.::|.|      |..| :.:.||
Human   150 KKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTG------KNTD-IFRSNG 207

  Fly    94 TNIPELDKRSLTICSNTDYINITYHHVICPDAATAKIWLDGIRKITHNVKANNICPMMCLRKHWM 158
            .:....:..:.::....:|.::   .::...|..|.||:.|:|.:....|  :...|:...:..|
Human   208 ISDQISEDCAFSVIYGENYESL---DLVANSADVANIWVTGLRYLISYGK--HTLDMLESSQDNM 267

  Fly   159 RLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIK--DAGLPDDKNATMTKE----------QFT 211
            |.|:..:...:|.|..|.........:     ||:  :.||...|.....||          :.|
Human   268 RTSWVSQMFSEIDVDNLGHITLCNAVQ-----CIRNLNPGLKTSKIELKFKELHKSKDKAGTEVT 327

  Fly   212 FDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPLYEEKRCTE 276
            .::|..::|::|.|.:|..|....:..| :|:..:..:.|:..:|....:||.:        ..|
Human   328 KEEFIEVFHELCTRPEIYFLLVQFSSNK-EFLDTKDLMMFLEAEQGVAHINEEI--------SLE 383

  Fly   277 IINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYINSSHNTYLSGR 341
            ||:.||..:|.::...:|:|||..||||.:......:......:|.|||:||:|||||||||...
Human   384 IIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIED 448

  Fly   342 QIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSS 406
            |..|.|.:..|.:.|..|||.||||.|:  |.|.||::..||...::|:|:..|..|...||.:|
Human   449 QFRGPSDITGYIRALKMGCRSVELDVWD--GPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFAS 511

  Fly   407 EYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLP---LPPPCKLKRKILIKN 468
            |||:||..||||:..||..:.::.....||.|       :...|.:.   ||.|..||.|||||.
Human   512 EYPLILCLENHCSIKQQKVMVQHMKKLLGDKL-------YTTSPNVEESYLPSPDVLKGKILIKA 569

  Fly   469 KRMKPEVEKVELELWLKGELKTDDDPEEDASAGKPPEAAAAP--APAPEAAAAAEGAAEGGGGAE 531
            |::......||      |:: ||:|...:.|.....|....|  .|........|
Human   570 KKLSSNCSGVE------GDV-TDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKE---------- 617

  Fly   532 AEAAAANYSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDF 596
                              ||.:|:..:.::|:.|..:.:......:.||.|.....|..::..||
Human   618 ------------------LSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDF 664

  Fly   597 VNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLK 661
            ||||||.::|::|...|.||||..||.||..|||:|::|||:..|.|.||.|.|..||.|||:|:
Human   665 VNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLR 729

  Fly   662 PDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQFLSDKK--------VGTYVEVDMFGLPSDT 718
            |..||.....|.......|.||......:|:|:||.....|        |..||.|::.|:|:|.
Human   730 PAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADC 794

  Fly   719 VKKEFRTRLVANNGLNPVYNEDPFVFRKVVLPDLAVLRFGVYEE---SGKILGQRILPLDGLQAG 780
            .  |.||:.|..||..|:::|. |.| ::.||:||::||.|.::   ..:.:||..:|.:.||.|
Human   795 A--EQRTKTVHQNGDAPIFDES-FEF-QINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTG 855

  Fly   781 YRHVSLRTEANFPMSLPMLFVNIELKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIEEQ 845
            ||||.|::.....::...|||::                                     .|..:
Human   856 YRHVPLQSLTGEVLAHASLFVHV-------------------------------------AITNR 883

  Fly   846 SGGAARDAGKAKEEEKKEPPLVFEPVTLESLRQEKGFQKVGKKQIKELDTLRKKHAKERTSVQKT 910
            .||                                     ||...:.|...:.|.::|..|::..
Human   884 RGG-------------------------------------GKPHKRGLSVRKGKKSREYASLRTL 911

  Fly   911 QNAAIDKLIKGKSKDDIRNDANIKNSINDQTKQWTDMIARHRKEEWDMLRQHVQDSQDAMKALML 975
            ....:|::.|           |.:..|.|.|.                ||:::|::..:.|.|..
Human   912 WIKTVDEVFK-----------NAQPPIRDATD----------------LRENMQNAVVSFKELCG 949

  Fly   976 TVQAAQIKQL----------EDRHARDIKDLNAKQAKMS-----ADTAKEVQND-----KTLKTK 1020
            ....|.:.|.          .|.....:.:|:.:...|.     .:..|::...     ::||..
Human   950 LSSVANLMQCMLAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKAL 1014

  Fly  1021 NEKDRRLREK---RQNNVKRFMEEKKQIGVKQGRAMEKLKLAHSKQIEEFSTDV 1071
            .|....:.||   .|.....|.|....||.|:|....||:    |.:|.|:.::
Human  1015 IENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQ----KAVESFTWNI 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	22/119 (18%)
		PLN02952	224..786	CDD:178538	194/577 (34%)
		EF-hand_like	227..318	CDD:286375	22/90 (24%)
		PI-PLCc_beta	318..653	CDD:176533	119/339 (35%)
		C2_PLC_like	689..806	CDD:175974	43/127 (34%)
		DUF1154	866..908	CDD:284131	6/41 (15%)
		Mer2	<887..1003	CDD:286200	20/125 (16%)
PLCL2	NP_001137854.1	PH_PLC_eta	143..251	CDD:270170	21/110 (19%)
		EFh_PRIP2	271..414	CDD:320053	37/156 (24%)
		EF-hand motif	271..300	CDD:320053	5/33 (15%)
		EF-hand motif	307..339	CDD:320053	6/31 (19%)
		EF-hand motif	343..371	CDD:320053	5/28 (18%)
		EF-hand motif	380..414	CDD:320053	14/41 (34%)
		PI-PLCc_PRIP_metazoa	425..721	CDD:176539	119/339 (35%)
		C2_PLC_like	753..881	CDD:175974	43/168 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820