DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment norpA and PLCH1

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	XP_005247295.1	Gene:	PLCH1 / 23007	HGNCID:	29185	Length:	1705	Species:	Homo sapiens

Alignment Length:	1165	Identity:	308/1165 - (26%)
Similarity:	497/1165 - (42%)	Gaps:	322/1165 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LFKVDEYGFFLYWK------------------SEGRDGDVIELCQVSDIRAGGTPKDPKILDKVT 89
            ||.:||:...|.|:                  :|||..::..       |......||...  .|
Human    53 LFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSEIFH-------RQAEGNFDPSCC--FT 108

  Fly    90 KKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKIWLDGIRKITHNVK-ANNICPMMCL 153
            ..:|.::..||    .|.||.:               .|:.|:.|::.:...:. .:::......
Human   109 IYHGNHMESLD----LITSNPE---------------EARTWITGLKYLMAGISDEDSLAKRQRT 154

  Fly   154 RKHWMRLSY-CVEKSG------------------KIPVKTLAKTFASGKTEKLVYTCIKDAGLPD 199
            ...|::.:: ..:|:|                  .:|.:.:.:.|....|              |
Human   155 HDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADT--------------D 205

  Fly   200 DKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEI 264
            :...|:     ||::|...|..:..|.|:..|..|.: .|:|.:::|:..||:..:|   :||.:
Human   206 ENQGTL-----TFEEFCVFYKMMSLRRDLYLLLLSYS-DKKDHLTVEELAQFLKVEQ---KMNNV 261

  Fly   265 LYPLYEEKRCTEIINDYELDEEKK-KNVQMSLDGFKRYLMS---DENAPVFLDRLDFYMEMDQPL 325
                 ....|.:||..:|:.||.| ||| :.::||..::.|   |...|:   ..:.|.:|||||
Human   262 -----TTDYCLDIIKKFEVSEENKVKNV-LGIEGFTNFMRSPACDIFNPL---HHEVYQDMDQPL 317

  Fly   326 AHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEIL 390
            .:|||.|||||||:|.|:..:|.|:||.:.|..||||||:|||:  |.|.||:|.||:...::||
Human   318 CNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWD--GPDGEPVVHHGYTLTSKIL 380

  Fly   391 FKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPG--LP 453
            |:|.::.|...|||.:|:|||||.||||:..||.|:|:|....|||     .|....:|.|  ..
Human   381 FRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGD-----KLDLSSVDTGECKQ 440

  Fly   454 LPPPCKLKRKILIKNKRM------------------KPEVE----------------------KV 478
            ||.|..||.|||:|.|::                  ..|:|                      :.
Human   441 LPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRK 505

  Fly   479 ELELWLK-GELKTDDDPEE--------------DASAGKPPEAAAAPAPAPEAAAAAEGAA---- 524
            :||..|| .:::..:||:.              :|...:.|:       ..|:...:.|.:
Human   506 KLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPD-------VKESGKKSHGRSLMTN 563

  Fly   525 EGGGGAEAEAAAANYS------------------------GSTTNVHPWLSSMVNYAQPIKFQGF 565
            .|......::.:.:||                        ..|..:...||.:|.|...:..|..
Human   564 FGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDI 628

  Fly   566 DKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQ 630
               ::.....|:.||:|:.....::|.|..|:.||::|::||||...|.||||:.|..:||||||
Human   629 ---VDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQ 690

  Fly   631 MVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAG 695
            :|:||:||....||||:.||:.||.|||:|||..|.:.  .|:||:..|:......|..:|||:|
Human   691 LVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKG--TFNPFSGDPLPANPKKQLILKVISG 753

  Fly   696 QFL---SDKKVG-------TYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRKVVLP 750
            |.|   .|...|       .:|||::.|||.|..|.:  ||:|.:||.|||: |:...| .|.:|
Human   754 QQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ--TRVVDDNGFNPVW-EETLTF-TVHMP 814

  Fly   751 DLAVLRFGVYEES--GK-ILGQRILPLDGLQAGYRHVSLR--TEANFPMSLPMLFVNIEL-KIYV 809
            ::|::||.|::..  |: .:|||.:....|..|||||.|.  |||:       :||:|.: :||
Human   815 EIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEAS-------IFVHITINEIY- 871

  Fly   810 PDGFEDFMAMLSDPR----GFAGAAKQQNEQMKALGIEEQSGGAARDAGKAKEEEKKEPPLVFEP 870
                ..:..::.:|.    .|.||.|  |.|::.|
Human   872 ----GKWSPLILNPSYTILHFLGATK--NRQLQGL------------------------------ 900

  Fly   871 VTLESLRQEKG-FQKVGKKQIKELDT--LRKKHAKERTSVQKTQNAAIDKLIKG--KSKDDIRND 930
                     || |.|..:....|.::  :||:...:|. :::|.:|.    .||  |||...:..
Human   901 ---------KGLFNKNPRHSSSENNSHYVRKRSIGDRI-LRRTASAP----AKGRKKSKMGFQEM 951

  Fly   931 ANIKNSINDQTKQWTDMIARHRKEEWDMLRQHVQDSQDAMKALMLTVQAAQIKQLEDRHARDIKD 995
            ..||:|:::.|:                      |....::....::||..:....||:.
Human   952 VEIKDSVSEATR----------------------DQDGVLRRTTRSLQARPVSMPVDRNL----- 989

  Fly   996 LNAKQAKMSADTAKEVQNDKTLKTKNEKDRRLREKRQNNVKRFMEEKKQIGVKQGRAMEK 1055
            |.|....:| :|||:::. |......:||.|.:.|.......|:...|::.......:.|
Human   990 LGALSLPVS-ETAKDIEG-KENSLAEDKDGRRKGKASIKDPHFLNFNKKLSSSSSALLHK 1047

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	22/124 (18%)
		PLN02952	224..786	CDD:178538	219/663 (33%)
		EF-hand_like	227..318	CDD:286375	26/94 (28%)
		PI-PLCc_beta	318..653	CDD:176533	136/419 (32%)
		C2_PLC_like	689..806	CDD:175974	49/132 (37%)
		DUF1154	866..908	CDD:284131	8/44 (18%)
		Mer2	<887..1003	CDD:286200	22/119 (18%)
PLCH1	XP_005247295.1	PH-like	34..140	CDD:302622	22/114 (19%)
		EFh	158..224	CDD:238008	12/84 (14%)
		EF-hand_7	159..220	CDD:290234	10/79 (13%)
		PLN02228	239..884	CDD:177873	225/691 (33%)
		EF-hand_like	239..310	CDD:286375	23/82 (28%)
		PI-PLCc_eta1	310..713	CDD:176569	136/419 (32%)
		AANH_like	<453..554	CDD:294206	13/107 (12%)
		C2_PLC_like	743..867	CDD:175974	50/134 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820