DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment norpA and Plcd4

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	XP_006495846.1	Gene:	Plcd4 / 18802	MGIID:	107469	Length:	833	Species:	Mus musculus

Alignment Length:	857	Identity:	264/857 - (30%)
Similarity:	408/857 - (47%)	Gaps:	147/857 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KETKENDFERDALFKVDEYGFFLYWKS--EGRDGDVIELCQVSDIRAGGTPKDPKIL----DKVT 89
            ::.:...:::...|::...|..::..|  |........:..|..||.|   :|.::|    ::..
Mouse    25 RKVRTKSWKKLRYFRLQNDGMTVWHGSQPESMPKPTFSISDVERIRKG---QDSELLRYLVEEFP 86

  Fly    90 KKNGTNI------PELDKRSLTICSNTDYINITYHHVICPDAATAKIWLDGIRKITHNVKANNIC 148
            .:.|..:      |.||                   ::......|:||:.|::.:...|.:.:..
Mouse    87 LEQGFTVVFHGRRPNLD-------------------LVANSVEEAQIWMRGLQLLVDLVASMDHQ 132

  Fly   149 PMM-CLRKHWM---------RLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDAGL--PDDK 201
            ..| .:...|.         |:|:       ...:.|.........|:..::..::|.:  .||.
Mouse   133 EQMDQMLNEWFQQADRNQDGRMSF-------REAQRLLLLMNVEMDEEYAFSLFQEADVTQSDDL 190

  Fly   202 NATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILY 266
            .:         ::|...|..:..|.:|||:|...:..||. ::|.:|:.|:..:|::..
Mouse   191 GS---------EEFVQFYKALTKRTEIEEIFEDFSSDKQK-LTLLEFVDFLRKEQKEKD------ 239

  Fly   267 PLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYIN 331
              :......|:|:.||..|..:....:|.|||.:||.|.:......|.|..|.:|.|||:|||||
Mouse   240 --HAPDLALELIDRYEPSENGRLLHVLSKDGFLKYLCSKDGNIFNSDCLPIYQDMTQPLSHYYIN 302

  Fly   332 SSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQ 396
            |||||||.|.|:.|:||||.|.:.|..||||||:|.|:  |.|.||:|.|||...:.|||||.:.
Mouse   303 SSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDTWD--GPDGEPVVYHGHTLTSRILFKDVLA 365

  Fly   397 AIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLK 461
            .:|..||.||:||:|||.||||...||..:|.:..:..|:.||:..|....:|   .:|.|.:|:
Mouse   366 TLAQYAFQSSDYPLILSLENHCTWEQQRTMAHHLTEILGEQLLRNTLEGLLVD---SMPSPEQLR 427

  Fly   462 RKILIKNKRMKP-EVEKVELELWLKGELKTDDDPEEDASAGKPPEAAAAPAPAPEAAAAAEGAAE 525
            .|||:|.|:::. ||:|.|.|...:.||:.|:.|:.|.::   ||....|.|..:..||......
Mouse   428 GKILVKGKKLRTIEVDKEEEEEEEEEELEKDEGPDLDPAS---PELDTQPQPETQGQAAGNKKER 489

  Fly   526 ---------------GGGGAEAEAAAAN---------YSGSTTNVHPWLSSMVNYAQPIKFQGFD 566
                           |...|:|.::...         ...|||.:.|.||::|.|.:.:.|..|.
Mouse   490 KKKVMKCPMSCLLICGHVMAQAPSSIPESILLSKQFLLLSSTTIMCPDLSALVVYLRTVPFCSFT 554

  Fly   567 KAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQM 631
            .:.|....:::|||:||...|.:|::..:||.:|.||:.|:||.|.|.||||:.||..||.||||
Mouse   555 HSKENYHIYDISSFSESKAKNLIKEAGNEFVQHNARQLCRVYPSGLRTDSSNFNPQEHWNVGCQM 619

  Fly   632 VSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQ 696
            |::|.|::...|.:..|.|..|||.||:|||:|:|.....|:|  :.|:....|....|:||:||
Mouse   620 VAMNMQTAGSAMDICDGLFRQNGGSGYVLKPEFLRDTQSSFNP--ERPISLYKAQILVVQVISGQ 682

  Fly   697 FLS--DKK-----VGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRKVVLPDLAV 754
            .|.  ||.     |...|:|:::|:|.||  ||..|..|.|||:||.:.| .|.|| :.:|:||:
Mouse   683 QLPKVDKTKETTVVDPLVKVELYGVPEDT--KEQETSHVENNGINPYWGE-TFYFR-LQVPELAM 743

  Fly   755 LRFGVYEESGK----ILGQRILPLD---------GLQA-----------------GYRHVSLRTE 789
            |||.|.:.|.|    .:||..||..         ||.|                 |||||||.:.
Mouse   744 LRFVVKDYSRKSRNNFIGQYTLPWTCMKQGETNLGLLANIPTVAPFLIEFFCPFPGYRHVSLLSR 808

  Fly   790 ANFPMSLPMLFV 801
            ....::...:||
Mouse   809 DGTSLNPASIFV 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	19/129 (15%)
		PLN02952	224..786	CDD:178538	230/623 (37%)
		EF-hand_like	227..318	CDD:286375	24/90 (27%)
		PI-PLCc_beta	318..653	CDD:176533	142/359 (40%)
		C2_PLC_like	689..806	CDD:175974	53/150 (35%)
		DUF1154	866..908	CDD:284131
		Mer2	<887..1003	CDD:286200
Plcd4	XP_006495846.1	PH_PLC_delta	18..133	CDD:270169	19/129 (15%)
		EF-hand_10	153..202	CDD:317225	9/64 (14%)
		PLN02228	207..773	CDD:177873	221/588 (38%)
		PI-PLCc_GDPD_SF	289..641	CDD:387364	142/359 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810