DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment norpA and Plcb3

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	NP_001277278.1	Gene:	Plcb3 / 18797	MGIID:	104778	Length:	1234	Species:	Mus musculus

Alignment Length:	1187	Identity:	422/1187 - (35%)
Similarity:	636/1187 - (53%)	Gaps:	150/1187 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PP----ELTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIR 74
            ||    .|..|..|.:|  :|:.:..|    ....:||..||||||.....:.|.:::..:.|.|
Mouse    15 PPTVVETLRRGSKFIKW--DEEASSRN----LVTLRVDPNGFFLYWTGPNMEVDTLDISSIRDTR 73

  Fly    75 AG---GTPKDPKILDKVTKKNGTNIPE--LDKRSLTICSNTDYINITYHHVICPDAATAKIWLDG 134
            .|   ..||||||.:.:    |...|:  |:::.:|:.:..|.:|.|:.:.:.....|.|:|.:.
Mouse    74 TGRYARLPKDPKIREVL----GFGGPDTRLEEKLMTVVAGPDPVNTTFLNFMAVQDDTVKVWSEE 134

  Fly   135 IRKITHNVKANNICPMMCLRKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDAGLPD 199
            :.|:..|:.|.|......|||.:.:|...|.:.|:||||.:.|.|::.|  |.|.|.::..||..
Mouse   135 LFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADK--KRVETALESCGLNF 197

  Fly   200 DKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSI-TKGKQDFISLEQFIQFMNDKQRDPRMNE 263
            :::.::..::|..:.|....:|:|.|.||:::...| .||| .:::|||.:.|:|.||||||:||
Mouse   198 NRSESIRPDEFPLEIFERFLNKLCLRPDIDKILLEIGAKGK-PYLTLEQLMDFINQKQRDPRLNE 261

  Fly   264 ILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHY 328
            :|||.....:...:|..||.:::..:..|||::||.|||..:||..:.|:.||..|:|.|||:.|
Mouse   262 VLYPPLRSSQARLLIEKYETNKQFLERDQMSMEGFSRYLGGEENGILPLEALDLSMDMTQPLSAY 326

  Fly   329 YINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKD 393
            :|||||||||:..|:.|.||||||||.||.||||||||.|.|:..:|||.:|||....||:..:|
Mouse   327 FINSSHNTYLTAGQLAGPSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRD 391

  Fly   394 CIQAIADCAFVSSEYPVILSFENHCNRA-QQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPP 457
            .::|||:.||.:|.||||||||||.:.| ||.|:|:||...|||.||.:||..:||..|:|||.|
Mouse   392 VLEAIAEAAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIDPLDKYPLSAGIPLPSP 456

  Fly   458 CKLKRKILIKN-KRMKPEVEKVELELWLKGELKTDDDPEEDASAGKPPEAAAAPAPAPEAAAAAE 521
            ..|..:||:|| ||.:|.....:..: .|..|:..:....::||...|.:....:|:.::.....
Mouse   457 QDLMGRILVKNKKRHRPSTGVPDSSV-RKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLS 520

  Fly   522 GAAEGG-----------GGAEAEAAAANY-------------------------------SGSTT 544
            ...|.|           .|.|:.:...|.                               :.|..
Mouse   521 NGEEVGLEKTSLEPQKSLGEESLSREPNVPMPDRDREDEEEDEEEEETTDPKKPTTDEGTASSEV 585

  Fly   545 NVHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYP 609
            |....:|::|||.:|:||:.|:.|.::|....||||.|:..|..|.:|.::||.|||:|:|||||
Mouse   586 NATEEMSTLVNYVEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYP 650

  Fly   610 KGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDP 674
            ||||.||||||||:|||.|||:|:||||:.|||||||.|.|||||..||||||:||||.||.|||
Mouse   651 KGTRVDSSNYMPQLFWNVGCQLVALNFQTLDLPMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDP 715

  Fly   675 FADAPVDGVIAAQCSVKVIAGQFLSDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNE 739
            |.:..|||::|....||||:||||||||||.||||||||||.|| ::::|||....|..|||::|
Mouse   716 FTEVIVDGIVANALRVKVISGQFLSDKKVGIYVEVDMFGLPVDT-RRKYRTRTSQGNSFNPVWDE 779

  Fly   740 DPFVFRKVVLPDLAVLRFGVYEESGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIE 804
            :||.|.|||||.||.||...:||.||.:|.||||:..:::||.:|.||.|||.|:.||.|.:..|
Mouse   780 EPFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYTE 844

  Fly   805 LKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIEEQSGGAARDAGKAKEEEKKEPP---- 865
            ...|:||..:|:...|.:|........|:.:|:.||..|.::        :|..|..:|.|
Mouse   845 ASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEA--------QASTETYQETPCQQP 901

  Fly   866 --------------------------------------------LVFE--PVTLESLRQEKGFQK 884
                                                        ::.|  |..||.||..|...|
Mouse   902 GSQLPSNPTPNPLDASPRWPPGPTTSSTSSSLSSPGQRDDLIASILSEVTPTPLEELRSHKAMVK 966

  Fly   885 VGKKQIKELDTLRKKHAKERTSVQK------TQNAAIDK-------LIKGKSKDDIRNDANIKNS 936
            :..:|.::|..|.|||.::..::.:      .|..|..|       |.|..:.:|::.:...|..
Mouse   967 LRSRQDRDLRELHKKHQRKAVALTRRLLDGLAQARAEGKCRPSPSALGKATNSEDVKEEEEAKQY 1031

  Fly   937 INDQTKQWTDMI-ARHRKEEWDMLR--QHVQDSQDAMKALML---TVQAAQIKQLEDRHARDIKD 995
            ...|.:|...:: .|..:.:.:..|  :|::.:...:|.::|   |.|..::|:|.:|..::::.
Mouse  1032 REFQNRQVQSLLELREAQADVETKRKLEHLRQAHQRLKEVVLDTHTTQFKRLKELNEREKKELQK 1096

  Fly   996 LNAKQAKMSADTAKEVQNDKTLKTKNEKDRRLREKRQNNVKRFMEEKKQ----IGVKQGRAMEKL 1056
            :..::...|...||..:..|......|.:||...:..|:::|..|.:||    :...|.:.:::|
Mouse  1097 ILDRKRNNSISEAKTREKHKKEVELTEINRRHITESVNSIRRLEEAQKQRHERLVAGQQQVLQQL 1161

  Fly  1057 KLAHSKQIEEFSTDVQK 1073
            :....|.:.:.:.:.|:
Mouse  1162 EEEEPKLLAQLTQECQE 1178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	38/136 (28%)
		PLN02952	224..786	CDD:178538	286/606 (47%)
		EF-hand_like	227..318	CDD:286375	38/91 (42%)
		PI-PLCc_beta	318..653	CDD:176533	166/378 (44%)
		C2_PLC_like	689..806	CDD:175974	68/116 (59%)
		DUF1154	866..908	CDD:284131	14/43 (33%)
		Mer2	<887..1003	CDD:286200	25/134 (19%)
Plcb3	NP_001277278.1	PH_PLC_beta	22..149	CDD:270167	38/136 (28%)
		EF-hand_like	225..315	CDD:286375	37/90 (41%)
		PI-PLCc_beta	316..694	CDD:176533	166/378 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	466..588		18/122 (15%)
		C2_PLC_like	729..844	CDD:175974	67/115 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	888..938		4/49 (8%)
		BAR	976..>1118	CDD:299863	27/141 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1001..1026		5/24 (21%)
		PLC-beta_C	1029..1202	CDD:285865	29/150 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1207..1234
		Interaction with SHANK2. /evidence=ECO:0000250	1231..1234
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102409
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750