DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment norpA and plc-1

DIOPT Version :9

Sequence 1:NP_001014720.1 Gene:norpA / 31376 FlyBaseID:FBgn0262738 Length:1095 Species:Drosophila melanogaster
Sequence 2:NP_001360638.1 Gene:plc-1 / 181274 WormBaseID:WBGene00004036 Length:3554 Species:Caenorhabditis elegans


Alignment Length:1264 Identity:291/1264 - (23%)
Similarity:497/1264 - (39%) Gaps:352/1264 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 CQVSDIRAGGTPKDPKILD------KVTKKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAA 126
            |:....|.|.||....|..      :|:..:|.:..|..::.||:....:...:          .
 Worm  2374 CKSWRSRGGETPNSGSISSSGQMSIQVSGLSGPSGKEFQEKPLTLVEFAELFRL----------F 2428

  Fly   127 TAKIWLDGIRKITHNVKANNICPMMCLR----KHWMRL-SYCVEKSGKIPVKTLAKTFASGKTEK 186
            ..::..| :|.:.::|.:....|..|.:    :|..|: |.....|.......|:..|.:     
 Worm  2429 NTRMRKD-LRDVFNDVLSTATTPQHCPKRERDRHSPRMQSRLASVSNSYNADFLSNDFLT----- 2487

  Fly   187 LVYTCIKDAGLPDDKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQF 251
                          :|..:|....: :|...:|:.:...: :..:...:...:...::.:....|
 Worm  2488 --------------RNTAVTSHHIS-EKQNKIYNALALAS-VNSMGGLMDTSRSSMLTPQMLRAF 2536

  Fly   252 MNDKQRDPRMNEILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLD 316
            :|..|    |.:|     :|:...::|.|:|.|...::..|||.:||.|:|..    ||....:.
 Worm  2537 VNTHQ----MEQI-----DEQTAIKLIQDHEPDGICRQKNQMSFEGFTRFLCD----PVNFAFVP 2588

  Fly   317 FYMEMDQ-----PLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEE 376
            ..:|.|:     ||:||||||||||||:|.|:.|.||.|||||.||.||||||||||:  |:|..
 Worm  2589 ETIEPDEEDLRYPLSHYYINSSHNTYLTGHQLKGPSSSEMYRQVLLTGCRCVELDCWD--GDDGL 2651

  Fly   377 PIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKE 441
            |::.|||...::|.|:..::.|...||::|:.|||||.||||:..||.|:|:......||||:..
 Worm  2652 PLIYHGHTLVSKIGFRQVVEIIKKSAFITSDLPVILSIENHCSLQQQAKMAQMFKTVLGDLLVSN 2716

  Fly   442 PLPDHPLDPGLPLPPPCKLKRKILIKNKRM----------------------------------- 471
            .|.:........||.|.::|.|||||||:|                                   
 Worm  2717 FLFEADFSDSPRLPCPLQMKNKILIKNKKMIVDPPTPLPMIERGAVQRGETQLNLHRKQSKNSYE 2781

  Fly   472 ---KPEVEKVELELWLKGELKTDDDPEEDASAGKPPEAAAAPAPAPEAAAAAEGAAE-------- 525
               ..|||..:|:.:|..|...:||.||       .:..:....:|:.:..||.:|.        
 Worm  2782 SSTVDEVEDDDLDEFLDDEENEEDDQEE-------VQVRSEKEDSPKTSKRAEKSARNIKQQDSL 2839

  Fly   526 -GGGGAEAEAAAANYSGSTTN-------------------------------VHPWLSSMVNYAQ 558
             .....|....:.:.:.|.||                               :.|.||.:|.|.|
 Worm  2840 CSDHSVEQAKPSTSKTTSKTNDRKTEDEVLYAQLAQNAIRNQQPRKNNTGVQIAPELSDIVIYMQ 2904

  Fly   559 PIKFQGF--------DKAIEKNIA----------------------------------------- 574
            ..||:||        .:.:|:..|                                         
 Worm  2905 ATKFKGFPPVDGIQSPRIMEEGPASASLSFSSRARTPSNLLNTPAPPRRQRSSTQLSQELAAEFL 2969

  Fly   575 -----------HNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAG 628
                       :.::|..|:|....:|:.....|:|.:..:.|.||.....||||:.|...|..|
 Worm  2970 GSVRANATATCYQVTSLNENAAKKLMKRHPAKCVSYTRDHLIRTYPSAKHYDSSNFNPINCWAHG 3034

  Fly   629 CQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKP----DFMRRADKDFDPFADAPVDGVIAAQCS 689
            .|||:||||:.|:.|.:||..||.:|.|||.|||    |........|.|.: ..:.|..|...:
 Worm  3035 MQMVALNFQTPDVIMAVNQAMFEQSGNCGYQLKPRCLWDESHLLYNKFLPLS-KDIAGHSALLLN 3098

  Fly   690 VKVIAGQ--FLSDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRKVVLPDL 752
            :.:|:||  :.:......|||:::.|:.:|.|::  ::::|..|.:||::|....:  ::...||
 Worm  3099 LTIISGQHVYPNTHYASLYVEIEVIGIHNDCVRE--KSKVVQRNSVNPIWNHTTQL--RIACVDL 3159

  Fly   753 AVLRFGVYE--ESGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNI----ELKIYVPD 811
            |.||..|.:  ::|:::..|::|:..::.|:||:.|||..|.|:...|:|:..    |..||:.|
 Worm  3160 AFLRIAVCDSGQNGRVVAHRVVPVKCIRPGFRHLPLRTPTNLPIDNAMIFLRTRFEQEEHIYLHD 3224

  Fly   812 -------GFEDFMAMLSD--PR--------------GFAGAAKQQNEQMKALGIEEQSGGAAR-- 851
                   ..|..:|..:|  |.              ...||...:.    |:.:..:||...:  
 Worm  3225 DDSNTYCNLEHTLAYRTDLTPNLSPTPILKKQIFVLRITGAFADET----AITVHSESGSTVKTV 3285

  Fly   852 ------DAGKAKEEEKKEPPLVFEPVTL-ESLRQEKGFQKVGKKQIKELD--------------- 894
                  :|||..::       |.|.|.: |||....|...: ::::..|:               
 Worm  3286 MQQALLNAGKNADQ-------VEEYVLIEESLPAPSGEDPI-EQRVLPLNEPIMDAVACWNGSMR 3342

  Fly   895 --TLRKKHAKERTSVQKTQNAAIDKLIK--------GKSKDDIRNDANIKNSINDQTKQWTDMIA 949
              .||||.:      ..:..|.|..:||        ..|...:..|.::|::.::|        .
 Worm  3343 RFVLRKKGS------DPSSRAWITSIIKSGTSGSSTSVSPSPLTKDGHVKSASSNQ--------L 3393

  Fly   950 RHRKEEWDMLRQHVQ----------------------DSQDAMKALM---LTVQAAQIKQLEDRH 989
            ..|..:.|...:|::                      .|:|...|::   :...||.|       
 Worm  3394 HGRSLDTDAFGEHLEVTEGLNPRARSMGDTFLVCVHNVSEDQPYAILRAGIHSTAADI------- 3451

  Fly   990 ARDIKDLNAKQAKMSADTAKEVQNDKTLKTKNEKDRRLREKRQNN--VKRFMEEKKQIGVKQGR- 1051
               |:.:..|..:.:.|.::.|..::|.........::..|..||  ..|.:.:.:.:...|.| 
 Worm  3452 ---IRQVFVKARRSNVDDSEFVLVEETCDDPKLNQGQMTPKYPNNRTTSRVLGQNENVWKAQSRW 3513

  Fly  1052 -AMEKLKLAHSKQ-----IEEFSTDVQKL 1074
             :|.:..|.:.|.     :|:..:.:.||
 Worm  3514 KSMGRFVLENRKDTVHATLEKVRSFISKL 3542

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
norpANP_001014720.1 PH_PLC_beta 17..149 CDD:270167 14/86 (16%)
PLN02952 224..786 CDD:178538 196/712 (28%)
EF-hand_like 227..318 CDD:286375 19/90 (21%)
PI-PLCc_beta 318..653 CDD:176533 139/477 (29%)
C2_PLC_like 689..806 CDD:175974 34/124 (27%)
DUF1154 866..908 CDD:284131 12/59 (20%)
Mer2 <887..1003 CDD:286200 24/165 (15%)
plc-1NP_001360638.1 Ank_2 193..328 CDD:372319
ANK repeat 193..219 CDD:293786
ANK repeat 221..293 CDD:293786
ANK repeat 295..328 CDD:293786
B41 <1421..1598 CDD:214604
RasGEF 1748..2019 CDD:214539
EFh_PI-PLCepsilon 2401..2581 CDD:320033 36/224 (16%)
EF-hand motif 2402..2429 CDD:320033 4/36 (11%)
EF-hand motif 2435..2500 CDD:320033 13/85 (15%)
EF-hand motif 2509..2544 CDD:320033 4/39 (10%)
PLN02952 2526..3215 CDD:178538 203/715 (28%)
EF-hand motif 2549..2581 CDD:320033 11/35 (31%)
PI-PLCc_epsilon 2595..3059 CDD:176538 137/472 (29%)
Ubiquitin_like_fold 3255..3349 CDD:391949 18/105 (17%)
RA2_PLC-epsilon 3421..3524 CDD:340478 19/112 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.010

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