DRSC/TRiP Functional Genomics Resources

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Protein Alignment norpA and egl-8

DIOPT Version :10

Sequence 1:NP_525069.2 Gene:norpA / 31376 FlyBaseID:FBgn0262738 Length:1095 Species:Drosophila melanogaster
Sequence 2:NP_001300014.1 Gene:egl-8 / 178537 WormBaseID:WBGene00001177 Length:1512 Species:Caenorhabditis elegans


Alignment Length:1514 Identity:545/1514 - (35%)
Similarity:784/1514 - (51%) Gaps:439/1514 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MTKKYEFDWIIPVPPELTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVI 65
            |.|:::|:|...:.|||..|.||||:     :.:....|.:|..::||.||||.|..||:|..|:
 Worm     1 MAKEFQFNWKPTIIPELLHGSVFDRY-----DDESTCLELNAQVRIDENGFFLRWLIEGKDAVVL 60

  Fly    66 ELCQVSDIRAGGTPKDPKILDKVTKKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKS 130
            ::.|:.:.|.||.|||.:|:.::.::..:.  .:.:|::.|....|.:|:....::......||:
 Worm    61 DMGQIWEARTGGLPKDGRIMFELEQRGASE--TIAERTIWITHGQDLVNVQSFFLVAESVELAKT 123

  Fly   131 WQKNLRLITHNNRATNVCPRVNLMKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDA 195
            .:..:..|..::|..:|||...|||:...|:..|.:..|||:|.:.|||:|||.||:|..|:.|.
 Worm   124 CRAGINDILKSSRIRHVCPTTQLMKYHTWLTMNVNERRKIPIKLIIKTFSSGKPEKMVQKCLNDL 188

  Fly   196 GLPDDK-------NATMTK----------------------EQFTFDKFYALYHKVCPRNDIEEL 231
            ||..||       |.:|.|                      :..||:||..||:|:|||.:::||
 Worm   189 GLGGDKYTPARVINRSMGKKFRNFYKCSRGRKRKEREELDVDILTFEKFQRLYNKICPRTEVQEL 253

  Fly   232 FTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPLYEEKRCTEIINDYELDEEKKKNVQMSLD 296
            |..:: |::::::.|:.|.|:|::|||||:||||:|.::.:|...::..:|.|.:.:::.:||.|
 Worm   254 FVKLS-GQKEYLTKERLINFLNEEQRDPRLNEILFPFFDSQRIVALLKKHENDIKYQEDGKMSGD 317

  Fly   297 GFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCR 361
            ||.|:||||||.||||||::.:|:|||||.||||||||||||:|||.|||||.|:|||.||:|||
 Worm   318 GFLRFLMSDENPPVFLDRIEMFMDMDQPLCHYYINSSHNTYLTGRQYGGKSSSEIYRQVLLSGCR 382

  Fly   362 CVELDCWNGKGEDE-EPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYK 425
            |:|||||:|.||:: |||:|||.|.||::.|||.:..|.|.||..|::||:|||||||:::.|.|
 Worm   383 CIELDCWDGTGENKGEPIITHGKAMCTDVFFKDVLVQIRDTAFARSDFPVVLSFENHCSKSNQLK 447

  Fly   426 LAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRKILIKNKRMKPEVEKVELELWLK-GELK 489
            :||||.|.|||:||.:|..|.|||||:.||.|.:|::||||||||:|.::|:.:|:.:|: |:|.
 Worm   448 MAKYCMDIFGDMLLSKPFEDAPLDPGVSLPSPNRLRKKILIKNKRLKTDIERHQLDQFLREGKLD 512

  Fly   490 TDDD-------------------------PEE---DAS--------------------------- 499
            .:|:                         |||   |.|                           
 Worm   513 EEDELNETPEVVGEDSVSPRSGGSGGTGAPEEVDDDTSDDDDDPSVQTSLNVMRTIPTVNTTSNN 577

  Fly   500 ----------------------------------------------------------------- 499
                                                                             
 Worm   578 GSNRSARSSLDTPSPSGGSLMVPDRATSTATSIKNAVLARSPNFSSLRQKLSFKRRQSPLAGDQR 642

  Fly   500 -------------------AGKPPEAAAA-----------------------------PA----- 511
                               :|.||.|.::                             ||     
 Worm   643 AHPEVEQPVSSSSPATPSISGPPPCATSSGSTSSITITTTGCSTSSSGPSKHILGGEMPAKENDE 707

  Fly   512 ----------------------------------PAPEAAAAAEGAAEG---------------- 526
                                              |.|.:::.|...|..                
 Worm   708 AHPELKQNFIAKNLKGFGFSKKQPDSSTSLLTASPTPSSSSMAMSNANNPFSSSTLNSPQPMERS 772

  Fly   527 -----------GG--GAEAEAAAA------------------------------NYSGSTTNVHP 548
                       ||  |.|..:.:|                              :|:|:|||:||
 Worm   773 RSEKRSFRQKKGGVFGDELHSDSAALIDFMRTASSRKKKPVLTKEEEERIFAEYHYTGATTNIHP 837

  Fly   549 WLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTR 613
            .|||:|||..|:||.|||.|...|:..:||||:||.|:.|||||:.:||||||||.|||||||.|
 Worm   838 LLSSLVNYTHPVKFSGFDVAEANNLHFHMSSFSESTGLGYLKQSAPEFVNYNKRQSSRIYPKGAR 902

  Fly   614 ADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADA 678
            .||||::||:||||||||||||||:.|:.||||.||||||||.||||||||:||.|:.||||:::
 Worm   903 VDSSNFLPQIFWNAGCQMVSLNFQTPDVYMQLNMGKFEYNGGSGYLLKPDFLRRPDRTFDPFSES 967

  Fly   679 PVDGVIAAQCSVKVIAGQFLSDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFV 743
            ||||||||.|||:||:||||||:|:||||||:|:|||:||::||.:|:::..|||||||||||||
 Worm   968 PVDGVIAAHCSVRVISGQFLSDRKIGTYVEVEMYGLPTDTIRKEHKTKVIPGNGLNPVYNEDPFV 1032

  Fly   744 FRKVVLPDLAVLRFGVYEESGKILGQRILPLDGLQAGYRHVSLRTEAN--FPMSLPMLFVNIELK 806
            |||||||:||||||.||:|:||.|||||||||||||||||:|||::.|  |.:| |:|||.|.:|
 Worm  1033 FRKVVLPELAVLRFAVYDENGKQLGQRILPLDGLQAGYRHISLRSDTNQSFILS-PVLFVQIVIK 1096

  Fly   807 IYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIEE----------------------QSGGA 849
            .||||.....:..|:|||.|....|::.|.:..:|:::                      |:|.:
 Worm  1097 TYVPDELSGLVDALADPRAFLSEQKKRQEALAHMGVDDSDIPDVPNTRNMALRHVKQPPRQNGSS 1161

  Fly   850 A------RDAGKAKEE--------------EKKEPPLV----FEPVTLESLRQEKGFQKVGKKQI 890
            |      ...|.|:.:              |:.:|..|    .:|:.::.||::|.|.|:.|:..
 Worm  1162 ADLLANNGQTGSARGDQTSSMASSTIRSPNEQPQPVAVDKFKVDPIEVDDLRRDKAFAKLLKRFQ 1226

  Fly   891 KELDTLRKKHAKERTSVQKTQNAA------------IDKLI----------KGKSK--------- 924
            ||||.|||||.|:|.|:||.|.|.            :||||          ||..:         
 Worm  1227 KELDDLRKKHQKQRDSIQKQQPARRRNSSIAWIQTNVDKLITNNRRSTKKEKGSRRSLTASVSSG 1291

  Fly   925 --------------------------------------------------DDIRNDANIKNSIND 939
                                                              .|:.|:..:::.:|.
 Worm  1292 CGSASGTVTVSVCSPSGASCSGYSTGGPSTPVACNSDGTGSPATIGSPVPQDLVNNDRVRSLVNT 1356

  Fly   940 QTKQWTDMIARHRKEEWDMLRQHVQDSQDAMKALMLTVQAAQIKQLEDRHARDIKDLNAKQAKMS 1004
            ||.:|:.|:.||.:||:::.:..:::..|.::.||...|..|:..|:.|...:.|||...|.|.|
 Worm  1357 QTGEWSAMVRRHDEEEFELKKVQLKEQFDLLRKLMSEAQKNQMLALKLRLEAEGKDLKQTQTKKS 1421

  Fly  1005 ADTAKEVQNDKTLKTKNEKDRRLREKRQNNVKRFMEEKKQIGVKQGRAMEKLKLAHSKQIEEFST 1069
            .:.||.:|.||.:|||.|:|||::|..:.|:|.|:||:|::.:|..:..|:|...|..|:|:...
 Worm  1422 MEDAKVIQLDKGIKTKAERDRRVKELNEKNLKMFVEERKRLAMKAQKHEEQLTKRHLDQLEQLDK 1486

  Fly  1070 DVQKLMDM----YKIEEEA 1084
            |..|.:|.    ||.|:.|
 Worm  1487 DFHKALDAEVGNYKEEQLA 1505

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
norpANP_525069.2 PH_PLC_beta 17..149 CDD:270167 36/131 (27%)
EFh_NorpA_like 154..306 CDD:320042 66/180 (37%)
EF-hand motif 154..183 CDD:320042 12/28 (43%)
EF-hand motif 189..218 CDD:320042 13/57 (23%)
EF-hand motif 227..256 CDD:320042 8/28 (29%)
EF-hand motif 273..306 CDD:320042 12/32 (38%)
PI-PLCc_beta 318..653 CDD:176533 206/602 (34%)
C2_PLC_like 689..806 CDD:175974 85/118 (72%)
DUF1154 865..909 CDD:461969 20/47 (43%)
PLC-beta_C 952..1073 CDD:462571 41/120 (34%)
egl-8NP_001300014.1 PH_PLC_beta 17..142 CDD:270167 36/131 (27%)
EFh_PI-PLCbeta 147..327 CDD:320030 66/180 (37%)
EF-hand motif 147..176 CDD:320030 12/28 (43%)
EF-hand motif 182..240 CDD:320030 13/57 (23%)
EF-hand motif 249..277 CDD:320030 8/28 (29%)
EF-hand motif 294..327 CDD:320030 12/32 (38%)
PI-PLCc_beta 339..>495 CDD:176533 101/155 (65%)
Herpes_BLLF1 <528..>668 CDD:282904 8/139 (6%)
PI-PLCc_GDPD_SF <839..942 CDD:472694 71/102 (70%)
C2_PLC_like 976..1096 CDD:175974 86/120 (72%)
DUF1154 1201..1245 CDD:461969 19/43 (44%)
PLC-beta_C 1372..1511 CDD:462571 46/134 (34%)

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