DRSC/TRiP Functional Genomics Resources

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Protein Alignment norpA and egl-8

DIOPT Version :9

Sequence 1:NP_001014720.1 Gene:norpA / 31376 FlyBaseID:FBgn0262738 Length:1095 Species:Drosophila melanogaster
Sequence 2:NP_001300014.1 Gene:egl-8 / 178537 WormBaseID:WBGene00001177 Length:1512 Species:Caenorhabditis elegans


Alignment Length:1514 Identity:544/1514 - (35%)
Similarity:781/1514 - (51%) Gaps:439/1514 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MTKKYEFDWIIPVPPELTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVI 65
            |.|:::|:|...:.|||..|.||||:     :.:....|.:|..::||.||||.|..||:|..|:
 Worm     1 MAKEFQFNWKPTIIPELLHGSVFDRY-----DDESTCLELNAQVRIDENGFFLRWLIEGKDAVVL 60

  Fly    66 ELCQVSDIRAGGTPKDPKILDKVTKKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKI 130
            ::.|:.:.|.||.|||.:|:.::.::..:.  .:.:|::.|....|.:|:....::......||.
 Worm    61 DMGQIWEARTGGLPKDGRIMFELEQRGASE--TIAERTIWITHGQDLVNVQSFFLVAESVELAKT 123

  Fly   131 WLDGIRKITHNVKANNICPMMCLRKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDA 195
            ...||..|..:.:..::||...|.|:...|:..|.:..|||:|.:.|||:|||.||:|..|:.|.
 Worm   124 CRAGINDILKSSRIRHVCPTTQLMKYHTWLTMNVNERRKIPIKLIIKTFSSGKPEKMVQKCLNDL 188

  Fly   196 GLPDDK-------NATMTK----------------------EQFTFDKFYALYHKVCPRNDIEEL 231
            ||..||       |.:|.|                      :..||:||..||:|:|||.:::||
 Worm   189 GLGGDKYTPARVINRSMGKKFRNFYKCSRGRKRKEREELDVDILTFEKFQRLYNKICPRTEVQEL 253

  Fly   232 FTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPLYEEKRCTEIINDYELDEEKKKNVQMSLD 296
            |..:: |::::::.|:.|.|:|::|||||:||||:|.::.:|...::..:|.|.:.:::.:||.|
 Worm   254 FVKLS-GQKEYLTKERLINFLNEEQRDPRLNEILFPFFDSQRIVALLKKHENDIKYQEDGKMSGD 317

  Fly   297 GFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCR 361
            ||.|:||||||.||||||::.:|:|||||.||||||||||||:|||.|||||.|:|||.||:|||
 Worm   318 GFLRFLMSDENPPVFLDRIEMFMDMDQPLCHYYINSSHNTYLTGRQYGGKSSSEIYRQVLLSGCR 382

  Fly   362 CVELDCWNGKGEDE-EPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYK 425
            |:|||||:|.||:: |||:|||.|.||::.|||.:..|.|.||..|::||:|||||||:::.|.|
 Worm   383 CIELDCWDGTGENKGEPIITHGKAMCTDVFFKDVLVQIRDTAFARSDFPVVLSFENHCSKSNQLK 447

  Fly   426 LAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRKILIKNKRMKPEVEKVELELWLK-GELK 489
            :||||.|.|||:||.:|..|.|||||:.||.|.:|::||||||||:|.::|:.:|:.:|: |:|.
 Worm   448 MAKYCMDIFGDMLLSKPFEDAPLDPGVSLPSPNRLRKKILIKNKRLKTDIERHQLDQFLREGKLD 512

  Fly   490 TDDD-------------------------PEE---DAS--------------------------- 499
            .:|:                         |||   |.|                           
 Worm   513 EEDELNETPEVVGEDSVSPRSGGSGGTGAPEEVDDDTSDDDDDPSVQTSLNVMRTIPTVNTTSNN 577

  Fly   500 ----------------------------------------------------------------- 499
                                                                             
 Worm   578 GSNRSARSSLDTPSPSGGSLMVPDRATSTATSIKNAVLARSPNFSSLRQKLSFKRRQSPLAGDQR 642

  Fly   500 -------------------AGKPPEAAAA-----------------------------PA----- 511
                               :|.||.|.::                             ||     
 Worm   643 AHPEVEQPVSSSSPATPSISGPPPCATSSGSTSSITITTTGCSTSSSGPSKHILGGEMPAKENDE 707

  Fly   512 ----------------------------------PAPEAAAAAEGAAEG---------------- 526
                                              |.|.:::.|...|..                
 Worm   708 AHPELKQNFIAKNLKGFGFSKKQPDSSTSLLTASPTPSSSSMAMSNANNPFSSSTLNSPQPMERS 772

  Fly   527 -----------GG--GAEAEAAAA------------------------------NYSGSTTNVHP 548
                       ||  |.|..:.:|                              :|:|:|||:||
 Worm   773 RSEKRSFRQKKGGVFGDELHSDSAALIDFMRTASSRKKKPVLTKEEEERIFAEYHYTGATTNIHP 837

  Fly   549 WLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTR 613
            .|||:|||..|:||.|||.|...|:..:||||:||.|:.|||||:.:||||||||.|||||||.|
 Worm   838 LLSSLVNYTHPVKFSGFDVAEANNLHFHMSSFSESTGLGYLKQSAPEFVNYNKRQSSRIYPKGAR 902

  Fly   614 ADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADA 678
            .||||::||:||||||||||||||:.|:.||||.||||||||.||||||||:||.|:.||||:::
 Worm   903 VDSSNFLPQIFWNAGCQMVSLNFQTPDVYMQLNMGKFEYNGGSGYLLKPDFLRRPDRTFDPFSES 967

  Fly   679 PVDGVIAAQCSVKVIAGQFLSDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFV 743
            ||||||||.|||:||:||||||:|:||||||:|:|||:||::||.:|:::..|||||||||||||
 Worm   968 PVDGVIAAHCSVRVISGQFLSDRKIGTYVEVEMYGLPTDTIRKEHKTKVIPGNGLNPVYNEDPFV 1032

  Fly   744 FRKVVLPDLAVLRFGVYEESGKILGQRILPLDGLQAGYRHVSLRTEAN--FPMSLPMLFVNIELK 806
            |||||||:||||||.||:|:||.|||||||||||||||||:|||::.|  |.:| |:|||.|.:|
 Worm  1033 FRKVVLPELAVLRFAVYDENGKQLGQRILPLDGLQAGYRHISLRSDTNQSFILS-PVLFVQIVIK 1096

  Fly   807 IYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIEE----------------------QSGGA 849
            .||||.....:..|:|||.|....|::.|.:..:|:::                      |:|.:
 Worm  1097 TYVPDELSGLVDALADPRAFLSEQKKRQEALAHMGVDDSDIPDVPNTRNMALRHVKQPPRQNGSS 1161

  Fly   850 A------RDAGKAKEE--------------EKKEPPLV----FEPVTLESLRQEKGFQKVGKKQI 890
            |      ...|.|:.:              |:.:|..|    .:|:.::.||::|.|.|:.|:..
 Worm  1162 ADLLANNGQTGSARGDQTSSMASSTIRSPNEQPQPVAVDKFKVDPIEVDDLRRDKAFAKLLKRFQ 1226

  Fly   891 KELDTLRKKHAKERTSVQKTQNAA------------IDKLI----------KGKSK--------- 924
            ||||.|||||.|:|.|:||.|.|.            :||||          ||..:         
 Worm  1227 KELDDLRKKHQKQRDSIQKQQPARRRNSSIAWIQTNVDKLITNNRRSTKKEKGSRRSLTASVSSG 1291

  Fly   925 --------------------------------------------------DDIRNDANIKNSIND 939
                                                              .|:.|:..:::.:|.
 Worm  1292 CGSASGTVTVSVCSPSGASCSGYSTGGPSTPVACNSDGTGSPATIGSPVPQDLVNNDRVRSLVNT 1356

  Fly   940 QTKQWTDMIARHRKEEWDMLRQHVQDSQDAMKALMLTVQAAQIKQLEDRHARDIKDLNAKQAKMS 1004
            ||.:|:.|:.||.:||:::.:..:::..|.::.||...|..|:..|:.|...:.|||...|.|.|
 Worm  1357 QTGEWSAMVRRHDEEEFELKKVQLKEQFDLLRKLMSEAQKNQMLALKLRLEAEGKDLKQTQTKKS 1421

  Fly  1005 ADTAKEVQNDKTLKTKNEKDRRLREKRQNNVKRFMEEKKQIGVKQGRAMEKLKLAHSKQIEEFST 1069
            .:.||.:|.||.:|||.|:|||::|..:.|:|.|:||:|::.:|..:..|:|...|..|:|:...
 Worm  1422 MEDAKVIQLDKGIKTKAERDRRVKELNEKNLKMFVEERKRLAMKAQKHEEQLTKRHLDQLEQLDK 1486

  Fly  1070 DVQKLMDM----YKIEEEA 1084
            |..|.:|.    ||.|:.|
 Worm  1487 DFHKALDAEVGNYKEEQLA 1505

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
norpANP_001014720.1 PH_PLC_beta 17..149 CDD:270167 36/131 (27%)
PLN02952 224..786 CDD:178538 349/829 (42%)
EF-hand_like 227..318 CDD:286375 39/90 (43%)
PI-PLCc_beta 318..653 CDD:176533 206/602 (34%)
C2_PLC_like 689..806 CDD:175974 85/118 (72%)
DUF1154 866..908 CDD:284131 20/45 (44%)
Mer2 <887..1003 CDD:286200 45/196 (23%)
egl-8NP_001300014.1 PH_PLC_beta 17..142 CDD:270167 36/131 (27%)
EF-hand_like 249..339 CDD:286375 39/90 (43%)
PI-PLCc_beta 339..>495 CDD:176533 101/155 (65%)
PI-PLCc_GDPD_SF <839..942 CDD:301322 71/102 (70%)
C2_PLC_like 976..1096 CDD:175974 86/120 (72%)
DUF1154 1202..1244 CDD:284131 19/41 (46%)
PLC-beta_C 1370..1511 CDD:285865 47/136 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160167010
Domainoid 1 1.000 223 1.000 Domainoid score I1470
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H8471
Inparanoid 1 1.050 1032 1.000 Inparanoid score I137
Isobase 1 0.950 - 0.721928 Normalized mean entropy S2835
OMA 1 1.010 - - QHG45247
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 1 1.000 - - FOG0000126
OrthoInspector 1 1.000 - - oto20790
orthoMCL 1 0.900 - - OOG6_102409
Panther 1 1.100 - - LDO PTHR10336
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3114
SonicParanoid 1 1.000 - - X5343
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1615.890

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