DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment norpA and plc-4

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	NP_501213.1	Gene:	plc-4 / 177525	WormBaseID:	WBGene00004039	Length:	751	Species:	Caenorhabditis elegans

Alignment Length:	842	Identity:	217/842 - (25%)
Similarity:	363/842 - (43%)	Gaps:	174/842 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 NEKETKE--NDFERDALF------KVDEYGF-------FL-----YW--------KSEGRDGDVI 65
            :|::|||  ...|:.:|.      ||.|...       ||     ||        ||       :
Worm    17 DEEKTKEELEWAEKGSLLCRIKNQKVKEMALVTIKSKQFLNYYSSYWFNFVPNALKS-------V 74

  Fly    66 ELCQVSDIRAGGTPKDPKILDKVTKKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKI 130
            .|.::.::|:|....:   |.:.:||  ....||...|.  |.:..:.:..:.|.....:|.:|.
Worm    75 ALSELLEVRSGYQTDN---LQRASKK--YEFQELAPESR--CFSVIFSHAKFLHKSVDFSADSKE 132

  Fly   131 WLD-GIRKITHNVKANNICPMMCLRKH---------WMRLSY---CVEKSGKI---PVKTLAKTF 179
            ..| .:..:||         ::.:.||         |:...:   ...|:|.:   .|..|.|..
Worm   133 TRDKWVSVLTH---------LISVAKHQRVVFNETAWLIDKFQQADTNKNGLLSFDEVWNLLKRM 188

  Fly   180 ASGKTEKLVYTCIKDAGLPDDKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFIS 244
            ....:|:......:::...:.::..:.:::     |...:.::..|.|:..:.|..:....:.::
Worm   189 NLQISERYAKAIFRESEFENSRDNKLNEKE-----FLNFFERLTDRPDLRFVMTQASSDNVETLT 248

  Fly   245 LEQFIQFMNDKQRDPRMNEILYPLYEEKRCTEIINDYELD-EEKKKNVQMSLDGFKRYLMSDENA 308
            :....:|:.::|.        :...:.|:..:|:..:|.. ::|:|...|.|.|.:| ||.....
Worm   249 VADLQRFLTEEQG--------FENVDLKKAEQILTTFEQTVQDKQKEKLMGLMGMRR-LMQSRWG 304

  Fly   309 PVFL-DRLDFYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKG 372
            .||. .....:.:|||||.||::||||||||:|.|:.|:::||.|...|..|.|.:|||.::  |
Worm   305 NVFKPGHESIFQDMDQPLTHYFVNSSHNTYLTGLQVKGEATVEGYISALRKGARLLELDLFD--G 367

  Fly   373 EDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDL 437
            |..||::||...:...|..::.::||...||.:|.|||||:.|||....||..:|....:..||.
Worm   368 EHGEPVITHKRTFIESITLRNSLEAIKRTAFETSPYPVILTLENHVGFVQQAVMADLFKEILGDS 432

  Fly   438 LLKEPLPDHPLDPGLPLPPPCKLKRKILIKNKRMKPEVEKVELELWLKGELKTDDDPEEDASAGK 502
            |...|...|    ..||..|.|||||.|::.|::..| |.:|             :|:||.|...
Worm   433 LYIPPKDSH----RHPLSSPNKLKRKFLLRGKKIILE-EDIE-------------EPDEDDSPTD 479

  Fly   503 PPEAAAAPAP-APEAAAAAEGAAEGGGGAEAEAAAANYSGSTTNVHPWLSSMVNYAQPIKFQGFD 566
            ..:....|.| |||.:|..        |..:...:.|.. ...|.||             |.| .
Worm   480 KDKHHVHPHPVAPELSALI--------GLPSVKLSHNIY-QDVNKHP-------------FDG-S 521

  Fly   567 KAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQM 631
            .::.:|..:.|.            ::::....|...::.:.||||.|.||||..|.|.|..|.|.
Worm   522 PSLSENKVYTMF------------EAAVPIFTYTAERLVKSYPKGLRQDSSNMHPMVSWLCGIQS 574

  Fly   632 VSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGV-------IAAQCS 689
            |::|||::...:.||.|.|..||.|||:|||..:              :|||       ...:..
Worm   575 VAMNFQTAGEELDLNAGLFRINGNCGYVLKPSCL--------------LDGVDPRSMAKPKLKLG 625

  Fly   690 VKVIAGQFLSDKKVG-----TYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRKVVL 749
            :.:.:.|:|...:.|     .||.|.:||:|.|..|.  :||::.:||.||.: .|.|.| .:..
Worm   626 IGLFSAQYLPKSEPGKEIIDPYVSVQIFGIPRDETKA--KTRIIKDNGFNPEW-RDNFYF-TLSC 686

  Fly   750 PDLAVLRFGVYE----ESGKILGQRILPLDGLQAGYRHVSLRTEANFPMS-LPMLFVNIELK 806
            |:||::||.|.:    .|...:|:..:|:..|:.|:..:.|.|.....:. ...|||.|.::
Worm   687 PELAIIRFCVKDFDSTSSNDFVGEFSIPVMSLRTGFSQIQLNTGYQHTLDPSASLFVRIAME 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	31/148 (21%)
		PLN02952	224..786	CDD:178538	170/580 (29%)
		EF-hand_like	227..318	CDD:286375	17/92 (18%)
		PI-PLCc_beta	318..653	CDD:176533	110/335 (33%)
		C2_PLC_like	689..806	CDD:175974	37/126 (29%)
		DUF1154	866..908	CDD:284131
		Mer2	<887..1003	CDD:286200
plc-4	NP_501213.1	PH-like	29..145	CDD:302622	27/138 (20%)
		EF-hand_7	161..223	CDD:290234	7/66 (11%)
		EF-hand_10	176..226	CDD:291454	5/54 (9%)
		PLN02228	221..751	CDD:177873	176/610 (29%)
		EF-hand_like	231..315	CDD:286375	17/92 (18%)
		PI-PLCc_eukaryota	315..596	CDD:176501	110/335 (33%)
		C2_PLC_like	621..748	CDD:175974	37/130 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820