DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment norpA and Plcd4

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	XP_006245198.1	Gene:	Plcd4 / 140693	RGDID:	621025	Length:	830	Species:	Rattus norvegicus

Alignment Length:	833	Identity:	257/833 - (30%)
Similarity:	400/833 - (48%)	Gaps:	134/833 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KETKENDFERDALFKVDEYGFFLYWKSEGRDGDVI-----ELCQVSDIRAGGTPKDPKILDKVTK 90
            ::.:...:::...|::.:.|..::   .||..:.|     .:..|..||.|   :|.::|..:.:
  Rat    25 RKVRTKSWKKLRYFRLQDDGMTVW---HGRHLESISKPTFSISDVERIRKG---QDSELLRYLVE 83

  Fly    91 K-----------NGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKIWLDGIRKITHNVKA 144
            :           ||.. |.||                   ::......|:.|:.|::.:...|..
  Rat    84 EFPLEQGFTIVFNGRR-PNLD-------------------LVANSVEEAQTWMRGLQLLVDLVAR 128

  Fly   145 NNICPMM-CLRKHWM---------RLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDAGLPD 199
            .|....: .:.:.|.         |:|:       ...:.|.........|:..::..::|.:
  Rat   129 MNYQEQLDQMLREWFQQADRNQDSRMSF-------REAQRLLLLMNVEMDEEYAFSLFQEADV-- 184

  Fly   200 DKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEI 264
            .::.|:..|:|.  :||....|   |.:|||||.:.:..||. ::|.:|:.|:.::|::...:..
  Rat   185 SQSNTLDSEEFV--QFYKALTK---RTEIEELFENFSSDKQK-LTLLEFVDFLREEQKESDHSSD 243

  Fly   265 LYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYY 329
            |        ..::|:.||..|..:....:|.|||..||.|.:......|.|..|.:|.|||:|||
  Rat   244 L--------ALKLIDRYEPSENGRLLRVLSKDGFLSYLCSADGNIFNPDCLPIYQDMTQPLSHYY 300

  Fly   330 INSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDC 394
            |||||||||.|.|..|:||||.|.:.|..||||||:|.|:  |.|.||:|.||....:.|||||.
  Rat   301 INSSHNTYLLGDQFCGQSSVEGYIRALKRGCRCVEVDTWD--GPDGEPVVYHGRTLTSRILFKDV 363

  Fly   395 IQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCK 459
            :..:|..||.||:||:|||.:|||...||..:|.:.....|:.||...|.:..:|   .:|.|.:
  Rat   364 LATLAQYAFQSSDYPLILSLDNHCTWEQQKTMAHHLIAILGEQLLSTTLEEQLID---IMPSPEQ 425

  Fly   460 LKRKILIKNKRMKPEVEKVELELWLKGELKTDDDPEEDASAGKPPEAAAAPAPA-PEAAAAAEGA 523
            |:.|||:|.|::: .:|.||.:       |.:::.|:|..:...|.:|.....: ||:...|.|.
  Rat   426 LRGKILVKGKKLR-TIEVVESD-------KEEEELEKDEGSDLDPASAELDMQSQPESQEQASGN 482

  Fly   524 AEGGGG-------------AEAEAAAAN-------------YSGSTTNVHPWLSSMVNYAQPIKF 562
            ......             |...|.|.|             ...|||.:.|.||::|.|.:...|
  Rat   483 KSKNKKKVMKCPMSCLLICAHVLAQAPNSIPESILLPKKFLLQSSTTILCPDLSALVVYLRTAPF 547

  Fly   563 QGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNA 627
            ..|..:.|....:::|||:||...|.::::..:||.:|.||:.|:||.|.|.|||||.||..||.
  Rat   548 CSFTHSKENYHIYDISSFSESKAKNLIREAGNEFVQHNARQLCRVYPSGLRTDSSNYNPQEHWNV 612

  Fly   628 GCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKV 692
            |||||::|.|::...|.:..|.|..|||.||:|||:|:|.....|:|.  .||....|....|:|
  Rat   613 GCQMVAMNMQTAGSAMDICDGLFRQNGGSGYVLKPEFLRDTQSSFNPM--KPVSLYKAQILVVQV 675

  Fly   693 IAGQFLS--DKK-----VGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRKVVLP 750
            |:||.|.  ||.     |...|.|:::|:|.||.::|  |..|.|||:||.:.| .|.| ::.:|
  Rat   676 ISGQRLPKVDKTKETTVVDPLVRVELYGVPEDTKQQE--TSYVENNGINPYWGE-TFYF-QIQVP 736

  Fly   751 DLAVLRFGVYEES----GKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPML 799
            :||:|||.|.:.|    ...:||..||...::.|  ..:||..||.|...|.|
  Rat   737 ELAMLRFVVKDYSRTSRNNFIGQYTLPWTCMKHG--ETNLRLLANIPTVAPFL 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	21/133 (16%)
		PLN02952	224..786	CDD:178538	217/599 (36%)
		EF-hand_like	227..318	CDD:286375	25/90 (28%)
		PI-PLCc_beta	318..653	CDD:176533	137/361 (38%)
		C2_PLC_like	689..806	CDD:175974	46/122 (38%)
		DUF1154	866..908	CDD:284131
		Mer2	<887..1003	CDD:286200
Plcd4	XP_006245198.1	PH-like	18..133	CDD:418428	21/133 (16%)
		EF-hand_10	153..202	CDD:405477	10/59 (17%)
		PLN02228	207..776	CDD:177873	217/598 (36%)
		PI-PLCc_GDPD_SF	289..638	CDD:417475	137/361 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920