DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment norpA and Plcz1

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	XP_006506962.1	Gene:	Plcz1 / 114875	MGIID:	2150308	Length:	689	Species:	Mus musculus

Alignment Length:	715	Identity:	233/715 - (32%)
Similarity:	346/715 - (48%)	Gaps:	122/715 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 KSGKIPVKTLAKTFASGKTEKLVYTC----IKDAGLPDDKNATMTKEQFTFDKFYALYHKVCPRN 226
            :.|||.|:...|..     |||.:.|    :|.....:|:   ..:.:.|.::|.|:|..:..|.
Mouse    23 RGGKINVEITHKLL-----EKLDFPCHFAHVKHIFKENDR---QNQGRITIEEFRAIYRCIVHRE 79

  Fly   227 DIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPLYEEKRCTEIINDYELDEEKKKNV 291
            :|.|:|.:.|:.:: .:|....|:|:..:|.:..:        :.....||||.||..||.|...
Mouse    80 EITEIFNTYTENRK-ILSENSLIEFLTQEQYEMEI--------DHSDSVEIINKYEPIEEVKGER 135

  Fly   292 QMSLDGFKRYLMSDENAPVFLDRL-DFYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQT 355
            |||::||.||:.|.| ..:|.:.. ..|.:|:.||:.|:|:|||||||...||.|.|.:..|...
Mouse   136 QMSIEGFARYMFSSE-CLLFKENCKTVYQDMNHPLSDYFISSSHNTYLISDQILGPSDIWGYVSA 199

  Fly   356 LLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNR 420
            |:.||||:|:|||:  |...||||.||:.:.:::|||..:|||...|||:|:|||:||.||||:.
Mouse   200 LVKGCRCLEIDCWD--GSQNEPIVYHGYTFTSKLLFKTVVQAINKYAFVTSDYPVVLSLENHCSP 262

  Fly   421 AQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRKILIKNKRMKPEVEKVELELWLK 485
            .||..:|......|||.||.:.|.:.| |   .||.|..||.|||:||:::....|..|
Mouse   263 GQQEVMASILQSTFGDFLLSDMLEEFP-D---TLPSPEALKFKILVKNRKVGTLSETHE------ 317

  Fly   486 GELKTD-------------DDPEEDASAGKPPEA-AAAPAPAPEAAAAAEGAAEGGGGAEAEAAA 536
             .:.||             :|.:||  :|..||. ....:...|...|......|..|.:.....
Mouse   318 -RIGTDKSGQVLEWKEVIYEDGDED--SGMDPETWDVFLSRIKEEREADPSTLSGIAGVKKRKRK 379

  Fly   537 ANYSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNK 601
            ...:.:       ||.:|.|.:..||:.|..:......:..:|..||......|....:|:.:..
Mouse   380 MKIAMA-------LSDLVIYTKAEKFRNFQYSRVYQQFNETNSIGESRARKLSKLRVHEFIFHTA 437

  Fly   602 RQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMR 666
            ..::|:|||..||||||:.||.|||.|||||:||||:..|||.|..|||..|||.||:||||.:|
Mouse   438 AFITRVYPKMMRADSSNFNPQEFWNVGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPDILR 502

  Fly   667 RADKDFDP----FADAPVDGVIAAQCSVKVIAGQFL----SDKKVGTYVEVDMFGLPSDTVKKEF 723
            .....|:|    :.|.||      ..::::|:|..|    |.......|.::::|:|:|.||::
Mouse   503 DTTLGFNPNEPEYDDHPV------TLTIRIISGIQLPVSSSSNTPDIVVIIEVYGVPNDHVKQQ- 560

  Fly   724 RTRLVANNGLNPVYNEDPFVFRKVVLPDLAVLRFGVYEESG-----KILGQRILPL--------- 774
             ||:|.||..:|.:|| .|.| .:.:|:||::||.|..:.|     ::|||..||:
Mouse   561 -TRVVKNNAFSPKWNE-TFTF-LIQVPELALIRFVVETQQGLLSGNELLGQYTLPVLCMNKVGNH 622

  Fly   775 -------------------DGLQAGYRHVSLRTEANFP-------MSLP-----MLFVNIELKIY 808
                               .....|.||..|..:..||       :.||     :|...:..|||
Mouse   623 ERMHTADPRVHATLFPGCTHRCSLGTRHAILWAQCEFPRLLISSMLLLPGLHSQLLVSFLRSKIY 687

Fly 809 808
Mouse 688 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167
		PLN02952	224..786	CDD:178538	209/617 (34%)
		EF-hand_like	227..318	CDD:286375	27/91 (30%)
		PI-PLCc_beta	318..653	CDD:176533	131/348 (38%)
		C2_PLC_like	689..806	CDD:175974	41/165 (25%)
		DUF1154	866..908	CDD:284131
		Mer2	<887..1003	CDD:286200
Plcz1	XP_006506962.1	EF-hand_7	21..73	CDD:372618	14/57 (25%)
		PLN02952	79..614	CDD:178538	205/576 (36%)
		PI-PLCc_GDPD_SF	162..489	CDD:387364	131/348 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820