DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment norpA and Plce1

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	NP_446210.1	Gene:	Plce1 / 114633	RGDID:	69424	Length:	2281	Species:	Rattus norvegicus

Alignment Length:	1136	Identity:	298/1136 - (26%)
Similarity:	465/1136 - (40%)	Gaps:	328/1136 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 SYCVEKSGK--IPVKTLAKTFASGKTEKL-----VYT--CIKDAGLPDDKNATMTKEQFTFDKFY 216
            |:.|..|..  |....|.|:|:....:.|     :|:  |.:.|.........:|.|:.|
  Rat  1186 SFMVSDSNMSFIEFVELFKSFSIRSRKDLKDIFDIYSVPCNRSASESTPLYTNLTIEENT----- 1245

  Fly   217 ALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRD----------------------- 258
                     ||::.....:|:...|.....:..|.::|.||.
  Rat  1246 ---------NDLQPDLDLLTRNVSDLGLFMKSKQQLSDNQRQISDAIAAASIVTNGTGIESTSLG 1301

  Fly   259 ------PRMNEILYPLYEEKRCT--EIINDYELDEEKKKNVQM------SLDGFKRYLMSDENAP 309
                  .::|:.|.....| .||  ||::   :.::.:.|:.|      |.:||.|:||..:|
  Rat  1302 IFGVGILQLNDFLVNCQGE-HCTYDEILS---IIQKFEPNISMCHQGLLSFEGFARFLMDKDN-- 1360

  Fly   310 VFLDRLDFYME----MDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNG 370
             |..:.|...|    :..||::|||.|||||||:|.|:.|:||||:|.|.||.|||.:|||||:
  Rat  1361 -FASKNDESRENKKDLQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSIELDCWD- 1423

  Fly   371 KGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFG 435
             |:|..||:.|||...|:|.||:.::||...||::|:.|:|:|.||||:..||.|:|:.....||
  Rat  1424 -GDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFITSDLPIIISIENHCSLPQQRKMAEIFKSVFG 1487

  Fly   436 DLLLKEPL--PDHPLDPGLPLPPPCKLKRKILIKNKRMK-------------------------- 472
            :.|:.:.|  .|...||  .||.|.:|:||:|:|||::|
  Rat  1488 EKLVAKFLFETDFSDDP--MLPSPDQLRRKVLLKNKKLKAHQTPVDILKQKAHQLASMQTQAFTG 1550

  Fly   473 ----------PEVEKVELELWLKGELKTDDDPEEDASAGKPPEAAAAP-------APAPEAAAAA 520
                      .|.|..|.|.....|..:||:..||    :|...:.|.       ...|:....|
  Rat  1551 GNANPPPASNEEEEDEEDEYDYDYESLSDDNILED----RPENKSCADKLQFEYNEEVPKRIKKA 1611

  Fly   521 EGAAEGGGGA-EAEAAAANY----SGSTTNVHPWLSSMVNYAQPIKFQGF------------DKA 568
            :.::...|.. :.|.....|    ...:..:.|.||.:|.|.|.:||.|.            ::.
  Rat  1612 DNSSGNKGKVYDMELGEEFYLPQNKKESRQIAPELSDLVIYCQAVKFPGLSTLNSSGSGRGKERK 1676

  Fly   569 IEKNI---------------------------------------------------AHNMSSFAE 582
            ..|:|                                                   .:::||..|
  Rat  1677 SRKSIFGNNPGRMSPGETASFNRTSGKSSCEGIRQIWEEPPLSPNTSLSAIIRTPKCYHISSLNE 1741

  Fly   583 SAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQ 647
            :|.....::.|...:.:...|:.|.||..||.||||..|.:||..|.|:|:||:|:.|||:.||.
  Rat  1742 NAAKRLCRRYSQKLIQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLVALNYQTDDLPLHLNA 1806

  Fly   648 GKFEYNGGCGYLLKPDFMRRADKD------FDPFADAPVDGVIAAQCSVKVIAGQFL--SDKKVG 704
            ..||.||||||:|||..:  .||.      |.|. :..:|.:..|..|:.:|:||.:  |:....
  Rat  1807 AMFEANGGCGYVLKPPVL--WDKSCPMYQKFSPL-ERDLDAMDPATYSLTIISGQNVCPSNSTGS 1868

  Fly   705 TYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRKVVLPDLAVLRFGVYE-ESGKILG 768
            ..:|||:.|:|.|:.  .|||:.:..|.|||::||. |:|| |...||..|||.|.| .|..|..
  Rat  1869 PCIEVDVLGMPLDSC--HFRTKPIHRNTLNPMWNEQ-FLFR-VHFEDLVFLRFAVVENNSSAITA 1929

  Fly   769 QRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIELKIYVPDGFEDFMAMLSD----------- 822
            |||:||..|:.||||:.||...|..:.:..||:|.......|.|.....:::.:
  Rat  1930 QRIIPLKALKRGYRHLQLRNLHNEILEISSLFINSRRMEDNPSGSTRPASLMFNTEERKCSQTHK 1994

  Fly   823 --------PRGFA-------GAAKQQNEQMKALGIEEQSGGAARD---------AGKAKEEEKKE 863
                    |..||       ..|||..:|:  |.:::.:...|.|         ..|.|.|.:|:
  Rat  1995 VTVHGVPGPEPFAVFTINEGTKAKQLLQQI--LAVDQDTKLTAADYFLMEEKHFISKEKNECRKQ 2057

  Fly   864 PPLVFEPVT---------LESLRQEKGFQKVGKKQIK-ELDTLRKKH----------AKERTS-- 906
            |   |:...         |.|...|:|:  ||:..:| :.:||.:|:          :.|..|
  Rat  2058 P---FQRAVGPEEDIVQILNSWFPEEGY--VGRIVLKPQQETLEEKNIVHDDREVILSSEEESFF 2117

  Fly   907 -------------------VQKTQNAAIDKLIKGKSKDDIRNDAN----------IKNSINDQTK 942
                               |...|:.....|.|.|....|.|:.|          :|::.|.::
  Rat  2118 VQVHDVSPEQPRTVIKAPRVSTAQDVIQQTLCKAKYSYSILNNPNPCDYVLLEEVMKDAPNKKS- 2181

  Fly   943 QWTDMIARHRKEEWDMLRQH-VQDSQDAMKA-------LMLTVQAAQIKQLEDRH-----ARDIK 994
                  :..:..:..:|.|. |..:|...|.       |...|||::    ||:.     |.::|
  Rat  2182 ------STPKSSQRILLDQECVFQAQSKWKGAGKFILKLKEQVQASR----EDKRRGISFASELK 2236

  Fly   995 DL--NAKQAKMSADTAKEVQNDKTLKTKNEK 1023
            .|  :.||.: ...:..::...:::::|.||
  Rat  2237 KLTKSTKQTR-GLTSPPQLVASESVQSKEEK 2266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167
		PLN02952	224..786	CDD:178538	219/724 (30%)
		EF-hand_like	227..318	CDD:286375	25/127 (20%)
		PI-PLCc_beta	318..653	CDD:176533	135/451 (30%)
		C2_PLC_like	689..806	CDD:175974	49/119 (41%)
		DUF1154	866..908	CDD:284131	13/82 (16%)
		Mer2	<887..1003	CDD:286200	32/172 (19%)
Plce1	NP_446210.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68
		GRF CDC25 domain	529..740
		RasGEF	531..710	CDD:279011
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1050..1146
		PLN02952	1299..1962	CDD:178538	215/684 (31%)
		EF-hand_like	<1309..1360	CDD:286375	15/54 (28%)
		PI-PLCc_epsilon	1372..1812	CDD:176538	134/447 (30%)
		PIPLC X domain	1373..1521		73/151 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1547..1572		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1664..1703		2/38 (5%)
		PIPLC Y domain	1734..1824		40/89 (45%)
		C2 domain	1839..1923		33/87 (38%)
		C2_PLC_like	1847..1963	CDD:175974	49/119 (41%)
		RA1 domain	1989..2093		23/110 (21%)
		RA2 domain	2114..2217		17/109 (16%)
		PLC_epsilon_RA	2116..2215	CDD:176375	15/105 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2239..2281		5/29 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820